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MGI:Stk4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Stk4 ( synonyms: Kas-2, Mst1, sterile 20-like kinase 1, Ysk3 ) | |
| Protein Name(s) | serine/threonine kinase 4, | |
| External Links | ||
| MGI | MGI:1929004 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000287 |
magnesium ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0000902 |
cell morphogenesis |
MGI:MGI:2177853 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:4412133 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0001841 |
neural tube formation |
MGI:MGI:4412133 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003157 |
endocardium development |
MGI:MGI:4412133 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:2177853 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3662967 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3785211 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103262 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:4420842 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2446967 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3785211 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2177853 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2446967 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3785211 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2177853 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007243 |
intracellular protein kinase cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007417 |
central nervous system development |
MGI:MGI:4412133 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4412133 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4420852 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030216 |
keratinocyte differentiation |
MGI:MGI:3785211 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103262 |
P |
From MGI |
||
| GO:0035329 |
hippo signaling cascade |
MGI:MGI:3785211 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103262 |
P |
From MGI |
||
| GO:0035329 |
hippo signaling cascade |
MGI:MGI:4420842 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035329 |
hippo signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:2177853 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4420852 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4420852 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043539 |
protein serine/threonine kinase activator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046621 |
negative regulation of organ growth |
MGI:MGI:4420852 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:2177853 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046983 |
protein dimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0060215 |
primitive hemopoiesis |
MGI:MGI:4412133 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0060706 |
cell differentiation involved in embryonic placenta development |
MGI:MGI:4412133 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4420852 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1928487 |
P |
From MGI |
||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Lee KK & Yonehara S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem 277: 12351-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Oh S et al. (2009) Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol 29: 6309-20 PubMed GONUTS page
- ↑ Katagiri K et al. (2006) Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol 7: 919-28 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Lee JH et al. (2008) A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J 27: 1231-42 PubMed GONUTS page
- ↑ 5.0 5.1 Lu L et al. (2010) Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A 107: 1437-42 PubMed GONUTS page
- ↑ 6.0 6.1 Lin Y et al. (2002) Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem 277: 47991-8001 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Song H et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 107: 1431-6 PubMed GONUTS page
