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MGI:Stk11
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Stk11 ( synonyms: Lkb1, Par-4 ) | |
| Protein Name(s) | serine/threonine kinase 11, | |
| External Links | ||
| MGI | MGI:1341870 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000287 |
magnesium ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001558 |
regulation of cell growth |
MGI:MGI:5142374 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001894 |
tissue homeostasis |
MGI:MGI:3778268 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579498 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:3611510 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4462353 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001944 |
vasculature development |
MGI:MGI:2148431 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002039 |
p53 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:3611510 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
F |
From MGI |
||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4462353 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:5142374 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4462353 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1342126 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4412462 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4462353 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5142374 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5142382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5284815 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1342126 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4412462 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:5142382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3611510 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006914 |
autophagy |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0072 |
P |
From MGI |
||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From MGI |
||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007286 |
spermatid development |
MGI:MGI:3829517 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007409 |
axonogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:4462353 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010212 |
response to ionizing radiation |
MGI:MGI:5284815 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:5142382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030010 |
establishment of cell polarity |
MGI:MGI:4462353 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
MGI:MGI:3778268 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579498 |
P |
From MGI |
||
| GO:0030275 |
LRR domain binding |
MGI:MGI:4412462 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030295 |
protein kinase activator activity |
MGI:MGI:3611510 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0030295 |
protein kinase activator activity |
MGI:MGI:4462353 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030295 |
protein kinase activator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:5142382 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:3788958 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
F |
From MGI |
||
| GO:0033993 |
response to lipid |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
P |
From MGI |
||
| GO:0042593 |
glucose homeostasis |
MGI:MGI:3611510 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043085 |
positive regulation of catalytic activity |
MGI:MGI:3611510 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043085 |
positive regulation of catalytic activity |
MGI:MGI:4462353 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043085 |
positive regulation of catalytic activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
C |
From MGI |
||
| GO:0043276 |
anoikis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045722 |
positive regulation of gluconeogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
P |
From MGI |
||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:5142374 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050772 |
positive regulation of axonogenesis |
MGI:MGI:4881884 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1891699 |
P |
From MGI |
||
| GO:0051291 |
protein heterooligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101539 |
P |
From MGI |
||
| GO:0051645 |
Golgi localization |
MGI:MGI:4881884 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051896 |
regulation of protein kinase B signaling cascade |
MGI:MGI:3778268 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579498 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3778268 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579498 |
P |
From MGI |
||
| GO:0060770 |
negative regulation of epithelial cell proliferation involved in prostate gland development |
MGI:MGI:3778268 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579498 |
P |
From MGI |
||
| GO:0072332 |
signal transduction by p53 class mediator resulting in induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Sapkota GP et al. (2002) Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J 362: 481-90 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Pearson HB et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res 68: 2223-32 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Shaw RJ et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Barnes AP et al. (2007) LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 129: 549-63 PubMed GONUTS page
- ↑ Ylikorkala A et al. (2001) Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293: 1323-6 PubMed GONUTS page
- ↑ 6.0 6.1 Smith DP et al. (1999) The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet 8: 1479-85 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Smith DP et al. (2001) LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Hum Mol Genet 10: 2869-77 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Sapkota GP et al. (2001) Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem 276: 19469-82 PubMed GONUTS page
- ↑ 9.0 9.1 Sapkota GP et al. (2002) Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J 368: 507-16 PubMed GONUTS page
- ↑ Towler MC et al. (2008) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J 416: 1-14 PubMed GONUTS page
- ↑ Katajisto P et al. (2008) LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet 40: 455-9 PubMed GONUTS page
- ↑ 12.0 12.1 Matsuki T et al. (2010) Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell 143: 826-36 PubMed GONUTS page
