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MGI:Stat5b
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Stat5b | |
| Protein Name(s) | signal transducer and activator of transcription 5B, | |
| External Links | ||
| MGI | MGI:103035 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000255 |
allantoin metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
MGI:MGI:4355633 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001553 |
luteinization |
MGI:MGI:2181561 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0001553 |
luteinization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001779 |
natural killer cell differentiation |
MGI:MGI:1332382 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2386424 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3577956 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:3577956 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
F |
From MGI |
||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5285141 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2386424 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2654404 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006101 |
citrate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006103 |
2-oxoglutarate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006105 |
succinate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006107 |
oxaloacetate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3054293 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0006366 |
transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006549 |
isoleucine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006573 |
valine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006600 |
creatine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006631 |
fatty acid metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006953 |
acute-phase response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007259 |
JAK-STAT cascade |
MGI:MGI:3577956 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007259 |
JAK-STAT cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007548 |
sex differentiation |
MGI:MGI:3769852 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
||
| GO:0007565 |
female pregnancy |
MGI:MGI:3526508 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0007565 |
female pregnancy |
MGI:MGI:3526508 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0007595 |
lactation |
MGI:MGI:2153620 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0007595 |
lactation |
MGI:MGI:2181561 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3577955 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0019218 |
regulation of steroid metabolic process |
MGI:MGI:3526508 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:3577956 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019530 |
taurine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019915 |
lipid storage |
MGI:MGI:2181561 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0030155 |
regulation of cell adhesion |
MGI:MGI:2153620 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0030856 |
regulation of epithelial cell differentiation |
MGI:MGI:2153620 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0032355 |
response to estradiol stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032819 |
positive regulation of natural killer cell proliferation |
MGI:MGI:3655409 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
||
| GO:0032825 |
positive regulation of natural killer cell differentiation |
MGI:MGI:3655409 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
||
| GO:0032870 |
cellular response to hormone stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033077 |
T cell differentiation in thymus |
MGI:MGI:3054293 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0035259 |
glucocorticoid receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0040014 |
regulation of multicellular organism growth |
MGI:MGI:3804595 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:2181561 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:2181561 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0042104 |
positive regulation of activated T cell proliferation |
MGI:MGI:1332382 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0042104 |
positive regulation of activated T cell proliferation |
MGI:MGI:3577956 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0042104 |
positive regulation of activated T cell proliferation |
MGI:MGI:3655409 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
||
| GO:0042448 |
progesterone metabolic process |
MGI:MGI:3526508 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0043029 |
T cell homeostasis |
MGI:MGI:1332382 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3577955 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0043434 |
response to peptide hormone stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045086 |
positive regulation of interleukin-2 biosynthetic process |
MGI:MGI:1332382 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045579 |
positive regulation of B cell differentiation |
MGI:MGI:1889695 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045588 |
positive regulation of gamma-delta T cell differentiation |
MGI:MGI:3054293 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045621 |
positive regulation of lymphocyte differentiation |
MGI:MGI:3054293 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045647 |
negative regulation of erythrocyte differentiation |
MGI:MGI:1332382 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045885 |
positive regulation of survival gene product expression |
MGI:MGI:3577955 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045931 |
positive regulation of mitotic cell cycle |
MGI:MGI:1332382 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2181561 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3577955 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3577956 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4355633 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:5285141 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
MGI:MGI:3655409 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
||
| GO:0046449 |
creatinine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046543 |
development of secondary female sexual characteristics |
MGI:MGI:2181561 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0046544 |
development of secondary male sexual characteristics |
MGI:MGI:2181561 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0046544 |
development of secondary male sexual characteristics |
MGI:MGI:2181561 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181609 |
P |
From MGI |
||
| GO:0048541 |
Peyer's patch development |
MGI:MGI:3054293 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050729 |
positive regulation of inflammatory response |
MGI:MGI:3577955 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103036 |
P |
From MGI |
||
| GO:0051272 |
positive regulation of cellular component movement |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060397 |
JAK-STAT cascade involved in growth hormone signaling pathway |
MGI:MGI:3828422 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060397 |
JAK-STAT cascade involved in growth hormone signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070669 |
response to interleukin-2 |
MGI:MGI:3655409 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
||
| GO:0070670 |
response to interleukin-4 |
MGI:MGI:3655409 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
||
| GO:0070672 |
response to interleukin-15 |
MGI:MGI:3655409 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181592 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Schirra HJ et al. (2008) Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study. PLoS One 3: e2764 PubMed GONUTS page
- ↑ 2.0 2.1 Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 106: 13463-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Teglund S et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93: 841-50 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
- ↑ 5.0 5.1 Olsen H et al. (2002) Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochem Biophys Res Commun 296: 139-44 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Moriggl R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11: 225-30 PubMed GONUTS page
- ↑ 7.0 7.1 Dhennin-Duthille I et al. (2011) The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction. J Biol Chem 286: 5034-42 PubMed GONUTS page
- ↑ Zhang SS et al. (2003) Expression and activation of STAT proteins during mouse retina development. Exp Eye Res 76: 421-31 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Kang J et al. (2004) STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 173: 2307-14 PubMed GONUTS page
- ↑ Laz EV et al. (2007) Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology 148: 3327-37 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Piekorz RP et al. (2005) Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol 19: 431-40 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Miyoshi K et al. (2001) Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol 155: 531-42 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 Kieslinger M et al. (2000) Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev 14: 232-44 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 Imada K et al. (1998) Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med 188: 2067-74 PubMed GONUTS page
- ↑ Sexl V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96: 2277-83 PubMed GONUTS page
- ↑ Yi W et al. (1996) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Mol Endocrinol 10: 1425-43 PubMed GONUTS page
