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MGI:Stat3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Stat3 ( synonyms: Aprf ) | |
| Protein Name(s) | signal transducer and activator of transcription 3, | |
| External Links | ||
| MGI | MGI:103038 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000981 |
sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001659 |
temperature homeostasis |
MGI:MGI:3039216 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451328 |
P |
From MGI |
||
| GO:0001754 |
eye photoreceptor cell differentiation |
MGI:MGI:3045481 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2154059 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2669060 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3581490 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR008967 |
F |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR013800 |
F |
From MGI |
||
| GO:0004879 |
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1933047 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2669078 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2669752 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3040789 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3581490 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3654744 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3688344 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3774679 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4441144 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5284803 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3688357 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2654404 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2678876 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3581490 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3654744 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4889014 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5284803 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2654404 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2669060 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3530170 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4889014 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5284803 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2678876 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:3688357 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006366 |
transcription from RNA polymerase II promoter |
MGI:MGI:2154059 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006606 |
protein import into nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006953 |
acute-phase response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0011 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR013800 |
P |
From MGI |
||
| GO:0007259 |
JAK-STAT cascade |
MGI:MGI:3688357 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:3581490 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:3688357 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:3843436 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0019953 |
sexual reproduction |
MGI:MGI:3039216 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451328 |
P |
From MGI |
||
| GO:0030522 |
intracellular receptor mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031730 |
CCR5 chemokine receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032355 |
response to estradiol stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032870 |
cellular response to hormone stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034097 |
response to cytokine stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035259 |
glucocorticoid receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0040014 |
regulation of multicellular organism growth |
MGI:MGI:3039216 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451328 |
P |
From MGI |
||
| GO:0042593 |
glucose homeostasis |
MGI:MGI:3039216 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451328 |
P |
From MGI |
||
| GO:0042755 |
eating behavior |
MGI:MGI:3039216 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451328 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3654744 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045747 |
positive regulation of Notch signaling pathway |
MGI:MGI:5284803 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:2154059 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3581490 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3654744 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96787 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4355633 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046983 |
protein dimerization activity |
MGI:MGI:2154059 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0048708 |
astrocyte differentiation |
MGI:MGI:5284803 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060019 |
radial glial cell differentiation |
MGI:MGI:5284803 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060396 |
growth hormone receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060397 |
JAK-STAT cascade involved in growth hormone signaling pathway |
MGI:MGI:3828422 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060397 |
JAK-STAT cascade involved in growth hormone signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070102 |
interleukin-6-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Fu AK et al. (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc Natl Acad Sci U S A 101: 6728-33 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gao Q et al. (2004) Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101: 4661-6 PubMed GONUTS page
- ↑ Ozawa Y et al. (2004) Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol Cell Neurosci 26: 258-70 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Turkson J et al. (2001) Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 276: 45443-55 PubMed GONUTS page
- ↑ 5.0 5.1 Ma J et al. (2003) A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J Biol Chem 278: 29252-60 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Hao A et al. (2005) The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol Biol Cell 16: 1569-83 PubMed GONUTS page
- ↑ Ilan N et al. (2001) Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse. Dev Biol 232: 219-32 PubMed GONUTS page
- ↑ Taler M et al. (2003) Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells. Mol Endocrinol 17: 1580-92 PubMed GONUTS page
- ↑ Nakayama K et al. (2002) A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. EMBO J 21: 6174-84 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Suzuki A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 103: 10294-9 PubMed GONUTS page
- ↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
- ↑ Muromoto R et al. (2008) BART is essential for nuclear retention of STAT3. Int Immunol 20: 395-403 PubMed GONUTS page
- ↑ Zhang T et al. (2000) The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6. Mol Cell Biol 20: 7132-9 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 Kamakura S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 6: 547-54 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Numata A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J Biol Chem 280: 12621-9 PubMed GONUTS page
- ↑ 16.0 16.1 Zhang SS et al. (2003) Expression and activation of STAT proteins during mouse retina development. Exp Eye Res 76: 421-31 PubMed GONUTS page
- ↑ 17.0 17.1 Fedorcsák P & Storeng R (2003) Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro. Biol Reprod 69: 1531-8 PubMed GONUTS page
- ↑ 18.0 18.1 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
- ↑ 19.0 19.1 Marroquí L et al. (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia 54: 843-51 PubMed GONUTS page
- ↑ Murphy K et al. (2005) Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes. Gene Expr Patterns 5: 475-82 PubMed GONUTS page
- ↑ Ohkawara B et al. (2004) Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev 18: 381-6 PubMed GONUTS page
- ↑ Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 106: 13463-8 PubMed GONUTS page
- ↑ Yi W et al. (1996) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Mol Endocrinol 10: 1425-43 PubMed GONUTS page
