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MGI:Sry
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sry ( synonyms: Tdf, Tdy ) | |
| Protein Name(s) | sex determining region of Chr Y, | |
| External Links | ||
| MGI | MGI:98660 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:78983 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2176613 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4833665 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005516 |
calmodulin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0112 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3609509 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4833665 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0007530 |
sex determination |
MGI:MGI:1196664 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1352460 |
P |
From MGI |
||
| GO:0007548 |
sex differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0726 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008301 |
DNA binding, bending |
MGI:MGI:3690807 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008584 |
male gonad development |
MGI:MGI:3851651 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:3027475 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0030238 |
male sex determination |
MGI:MGI:3580945 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1352460 |
P |
From MGI |
||
| GO:0030238 |
male sex determination |
MGI:MGI:3639791 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104723 |
P |
From MGI |
||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000020 |
positive regulation of male gonad development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Collignon J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122: 509-20 PubMed GONUTS page
- ↑ Zhang J et al. (1999) In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Biol 43: 219-27 PubMed GONUTS page
- ↑ 3.0 3.1 Oh HJ et al. (2005) Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod 72: 407-15 PubMed GONUTS page
- ↑ Wilhelm D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol 287: 111-24 PubMed GONUTS page
- ↑ Swain A et al. (1998) Dax1 antagonizes Sry action in mammalian sex determination. Nature 391: 761-7 PubMed GONUTS page
- ↑ Giese K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 9: 995-1008 PubMed GONUTS page
- ↑ Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet 18: 2989-3001 PubMed GONUTS page
- ↑ Nishino K et al. (2002) Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev Growth Differ 44: 35-43 PubMed GONUTS page
- ↑ Gomez G et al. (2005) TGF-beta 1 inhibits mast cell Fc epsilon RI expression. J Immunol 174: 5987-93 PubMed GONUTS page
- ↑ Kim Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4: e187 PubMed GONUTS page
