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MGI:Srgn
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Srgn ( synonyms: Prg1, Sgc ) | |
| Protein Name(s) | serglycin, | |
| External Links | ||
| MGI | MGI:97756 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
MGI:MGI:3715093 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005518 |
collagen binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016485 |
protein processing |
MGI:MGI:3715689 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030502 |
negative regulation of bone mineralization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031214 |
biomineral tissue development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0091 |
P |
From MGI |
||
| GO:0033364 |
mast cell secretory granule organization |
MGI:MGI:3056870 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033371 |
T cell secretory granule organization |
MGI:MGI:3717516 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033373 |
maintenance of protease location in mast cell secretory granule |
MGI:MGI:3762431 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033382 |
maintenance of granzyme B location in T cell secretory granule |
MGI:MGI:3717516 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042588 |
zymogen granule |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042629 |
mast cell granule |
MGI:MGI:3056870 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0050710 |
negative regulation of cytokine secretion |
MGI:MGI:3695245 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
|
colocalizes_with |
GO:0000139 |
Golgi membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Toyama-Sorimachi N et al. (1995) A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. J Biol Chem 270: 7437-44 PubMed GONUTS page
- ↑ Lundequist A et al. (2006) Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases. Biol Chem 387: 1513-9 PubMed GONUTS page
- ↑ 3.0 3.1 Abrink M et al. (2004) Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem 279: 40897-905 PubMed GONUTS page
- ↑ 4.0 4.1 Grujic M et al. (2005) Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J Biol Chem 280: 33411-8 PubMed GONUTS page
- ↑ Henningsson F et al. (2006) A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J 273: 4901-12 PubMed GONUTS page
- ↑ Zernichow L et al. (2006) Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J Biol Chem 281: 26792-801 PubMed GONUTS page
