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MGI:Srf

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Srf
Protein Name(s) serum response factor,
External Links
MGI MGI:106658

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000790

nuclear chromatin

MGI:MGI:4839449
PMID:16427017[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0001076

RNA polymerase II transcription factor binding transcription factor activity

MGI:MGI:2136697
PMID:11439182[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

F

From MGI

GO:0001569

patterning of blood vessels

MGI:MGI:3811944
PMID:18804439[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:1312998
PMID:9799237[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158696

P

From MGI

GO:0001707

mesoderm formation

MGI:MGI:1312998
PMID:9799237[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158696

P

From MGI

GO:0001707

mesoderm formation

MGI:MGI:1927031
PMID:11060034[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158696

P

From MGI

GO:0001764

neuron migration

MGI:MGI:3578447
PMID:15837932[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385464
MGI:MGI:2181426

P

From MGI

GO:0001829

trophectodermal cell differentiation

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0001947

heart looping

MGI:MGI:3603734
PMID:15929941[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385465
MGI:MGI:2386742

P

From MGI

GO:0002011

morphogenesis of an epithelial sheet

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0002042

cell migration involved in sprouting angiogenesis

MGI:MGI:3811944
PMID:18804439[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0002042

cell migration involved in sprouting angiogenesis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0002521

leukocyte differentiation

MGI:MGI:4848276
PMID:20709909[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779
MGI:MGI:2176073

P

From MGI

GO:0003677

DNA binding

MGI:MGI:1933899
PMID:11278942[10]

IGI: Inferred from Genetic Interaction

MGI:MGI:109617

F

From MGI

GO:0003677

DNA binding

MGI:MGI:2651740
PMID:12486129[11]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003677

DNA binding

MGI:MGI:3697003
PMID:17030628[12]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003677

DNA binding

MGI:MGI:4940955
PMID:21098124[13]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003677

DNA binding

MGI:MGI:84331
PMID:8900044[14]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:4950833
PMID:21379568[15]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2653712
PMID:12525493[16]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:84331
PMID:8900044[14]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

MGI:MGI:4950833
PMID:21379568[15]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:2663933
PMID:12397177[17]

IPI: Inferred from Physical Interaction

UniProtKB:P59759

F

From MGI

GO:0005515

protein binding

MGI:MGI:3688344
PMID:15102471[18]

IPI: Inferred from Physical Interaction

UniProtKB:Q3U1N2

F

From MGI

GO:0005515

protein binding

MGI:MGI:3697003
PMID:17030628[12]

IPI: Inferred from Physical Interaction

UniProtKB:B9EJ16
UniProtKB:Q9ERF6

F

From MGI

GO:0005515

protein binding

MGI:MGI:3796777
PMID:18458156[19]

IPI: Inferred from Physical Interaction

UniProtKB:P97474-3

F

From MGI

GO:0005515

protein binding

MGI:MGI:3831457
PMID:18945672[20]

IPI: Inferred from Physical Interaction

UniProtKB:B9EJ16

F

From MGI

GO:0005515

protein binding

MGI:MGI:3850304
PMID:19350017[21]

IPI: Inferred from Physical Interaction

UniProtKB:Q8C8N2
UniProtKB:Q8K4J6

F

From MGI

GO:0005515

protein binding

MGI:MGI:5007924
PMID:19342595[22]

IPI: Inferred from Physical Interaction

UniProtKB:B9EJ16
UniProtKB:Q3TKT4

F

From MGI

GO:0005634

nucleus

MGI:MGI:2653712
PMID:12525493[16]

IC: Inferred by Curator

GO:0003700

C

From MGI

GO:0005634

nucleus

MGI:MGI:3603734
PMID:15929941[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3722454
PMID:17576768[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001102772

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:F5H6V4

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3722454
PMID:17576768[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:F5H6V4

C

From MGI

GO:0005783

endoplasmic reticulum

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:F5H6V4

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2653712
PMID:12525493[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006366

transcription from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0007015

actin filament organization

MGI:MGI:3811944
PMID:18804439[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0007160

cell-matrix adhesion

MGI:MGI:4834086
PMID:20525922[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3764698

P

From MGI

GO:0007160

cell-matrix adhesion

MGI:MGI:4848276
PMID:20709909[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779
MGI:MGI:2176073

P

From MGI

GO:0007160

cell-matrix adhesion

MGI:MGI:4949974
PMID:21401944[25]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2450311

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007369

gastrulation

MGI:MGI:1312998
PMID:9799237[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158696

P

From MGI

GO:0007507

heart development

MGI:MGI:3045681
PMID:15169892[26]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779

P

From MGI

GO:0007507

heart development

MGI:MGI:3603734
PMID:15929941[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385465
MGI:MGI:2386742

P

From MGI

GO:0007616

long-term memory

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001102772

P

From MGI

GO:0008134

transcription factor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

F

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001102772

P

From MGI

GO:0008306

associative learning

MGI:MGI:3652465
PMID:16600861[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385465
MGI:MGI:2678305

P

From MGI

GO:0009725

response to hormone stimulus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0010669

epithelial structure maintenance

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0010735

positive regulation of transcription via serum response element binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0010736

serum response element binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

F

From MGI

GO:0010736

serum response element binding

MGI:MGI:81509
PMID:2062642[28]

IDA: Inferred from Direct Assay

F

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:4949974
PMID:21401944[25]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2450311

P

From MGI

GO:0021766

hippocampus development

MGI:MGI:3578447
PMID:15837932[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385464
MGI:MGI:2181426

P

From MGI

GO:0022028

tangential migration from the subventricular zone to the olfactory bulb

MGI:MGI:3578447
PMID:15837932[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385464
MGI:MGI:2181426

P

From MGI

GO:0030036

actin cytoskeleton organization

MGI:MGI:3578447
PMID:15837932[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385464
MGI:MGI:2181426

P

From MGI

GO:0030036

actin cytoskeleton organization

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0030038

contractile actin filament bundle assembly

MGI:MGI:3513738
PMID:15569937[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3522214

P

From MGI

GO:0030155

regulation of cell adhesion

MGI:MGI:3811944
PMID:18804439[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0030168

platelet activation

MGI:MGI:4834086
PMID:20525922[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3764698

P

From MGI

GO:0030220

platelet formation

MGI:MGI:4834086
PMID:20525922[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3764698

P

From MGI

GO:0030220

platelet formation

MGI:MGI:4848276
PMID:20709909[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779
MGI:MGI:2176073

P

From MGI

GO:0030336

negative regulation of cell migration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001102772

P

From MGI

GO:0031175

neuron projection development

MGI:MGI:3840718
PMID:19357276[30]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385464
MGI:MGI:2181426

P

From MGI

GO:0031490

chromatin DNA binding

MGI:MGI:3796777
PMID:18458156[19]

IDA: Inferred from Direct Assay

F

From MGI

GO:0033561

regulation of water loss via skin

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0034097

response to cytokine stimulus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0035855

megakaryocyte development

MGI:MGI:4834086
PMID:20525922[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3764698

P

From MGI

GO:0035855

megakaryocyte development

MGI:MGI:4848276
PMID:20709909[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779
MGI:MGI:2176073

P

From MGI

GO:0035912

dorsal aorta morphogenesis

MGI:MGI:3513738
PMID:15569937[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3522214

P

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

F

From MGI

GO:0043149

stress fiber assembly

MGI:MGI:4834086
PMID:20525922[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3764698

P

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001102772

F

From MGI

GO:0043589

skin morphogenesis

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0045059

positive thymic T cell selection

MGI:MGI:4940955
PMID:21098124[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779
MGI:MGI:2449947

P

From MGI

GO:0045214

sarcomere organization

MGI:MGI:3513738
PMID:15569937[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3522214

P

From MGI

GO:0045597

positive regulation of cell differentiation

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001102772

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:5294532
PMID:19797053[31]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1933899
PMID:11278942[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3603734
PMID:15929941[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3604097

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3641341
PMID:16824956[32]

IGI: Inferred from Genetic Interaction

MGI:MGI:1344313
MGI:MGI:1201674

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3709528
PMID:16510470[33]

IGI: Inferred from Genetic Interaction

MGI:MGI:107516
MGI:MGI:108067

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4353605
PMID:18511849[34]

IGI: Inferred from Genetic Interaction

MGI:MGI:2137495

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:84331
PMID:8900044[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045987

positive regulation of smooth muscle contraction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0046016

positive regulation of transcription by glucose

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001102772

P

From MGI

GO:0046716

muscle cell homeostasis

MGI:MGI:3529423
PMID:15647354[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385465

P

From MGI

GO:0046983

protein dimerization activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002100

F

From MGI

GO:0048589

developmental growth

MGI:MGI:1312998
PMID:9799237[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158696

P

From MGI

GO:0048821

erythrocyte development

MGI:MGI:4848276
PMID:20709909[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779
MGI:MGI:2176073

P

From MGI

GO:0051491

positive regulation of filopodium assembly

MGI:MGI:3811944
PMID:18804439[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0055003

cardiac myofibril assembly

MGI:MGI:3513738
PMID:15569937[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3522214

P

From MGI

GO:0060218

hemopoietic stem cell differentiation

MGI:MGI:4848276
PMID:20709909[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046779
MGI:MGI:2176073

P

From MGI

GO:0060261

positive regulation of transcription initiation from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI

GO:0060292

long term synaptic depression

MGI:MGI:3652465
PMID:16600861[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2385465
MGI:MGI:2678305

P

From MGI

GO:0060347

heart trabecula formation

MGI:MGI:3513738
PMID:15569937[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3522214

P

From MGI

GO:0060947

cardiac vascular smooth muscle cell differentiation

MGI:MGI:3513738
PMID:15569937[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:3522214

P

From MGI

GO:0061029

eyelid development in camera-type eye

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0070830

tight junction assembly

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0090009

primitive streak formation

MGI:MGI:1312998
PMID:9799237[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158696

P

From MGI

GO:0090136

epithelial cell-cell adhesion

MGI:MGI:4421610
PMID:20047077[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522206
MGI:MGI:2445832

P

From MGI

GO:0090398

cellular senescence

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P11831

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ Riccio A et al. (2006) A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell 21: 283-94 PubMed GONUTS page
  2. ↑ Wang D et al. (2001) Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105: 851-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Franco CA et al. (2008) Serum response factor is required for sprouting angiogenesis and vascular integrity. Dev Cell 15: 448-61 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Arsenian S et al. (1998) Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J 17: 6289-99 PubMed GONUTS page
  5. ↑ Weinhold B et al. (2000) Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation. EMBO J 19: 5835-44 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Alberti S et al. (2005) Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci U S A 102: 6148-53 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Niu Z et al. (2005) Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 280: 32531-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Verdoni AM et al. (2010) Serum response factor is essential for the proper development of skin epithelium. Mamm Genome 21: 64-76 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Ragu C et al. (2010) The transcription factor Srf regulates hematopoietic stem cell adhesion. Blood 116: 4464-73 PubMed GONUTS page
  10. ↑ 10.0 10.1 Herring BP et al. (2001) Identification of Barx2b, a serum response factor-associated homeodomain protein. J Biol Chem 276: 14482-9 PubMed GONUTS page
  11. ↑ Meech R et al. (2003) The homeodomain protein Barx2 promotes myogenic differentiation and is regulated by myogenic regulatory factors. J Biol Chem 278: 8269-78 PubMed GONUTS page
  12. ↑ 12.0 12.1 Hayashi K et al. (2006) Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription. Mol Cell Biol 26: 9456-70 PubMed GONUTS page
  13. ↑ 13.0 13.1 Mylona A et al. (2011) The essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signaling. Mol Cell Biol 31: 267-76 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 Chen CY et al. (1996) Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements. Dev Genet 19: 119-30 PubMed GONUTS page
  15. ↑ 15.0 15.1 Schlesinger J et al. (2011) The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet 7: e1001313 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 Baumeister MA et al. (2003) Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J Biol Chem 278: 11457-64 PubMed GONUTS page
  17. ↑ Wang DZ et al. (2002) Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A 99: 14855-60 PubMed GONUTS page
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  20. ↑ Zhou J et al. (2008) Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding. J Biol Chem 283: 35383-92 PubMed GONUTS page
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  24. ↑ 24.0 24.1 24.2 24.3 24.4 Halene S et al. (2010) Serum response factor is an essential transcription factor in megakaryocytic maturation. Blood 116: 1942-50 PubMed GONUTS page
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  26. ↑ Parlakian A et al. (2004) Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol 24: 5281-9 PubMed GONUTS page
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  31. ↑ Sun Q et al. (2009) Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J Biol Chem 284: 32582-90 PubMed GONUTS page
  32. ↑ Nishimura G et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell 11: 93-104 PubMed GONUTS page
  33. ↑ Yin Z et al. (2006) Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol 291: L191-9 PubMed GONUTS page
  34. ↑ Petit MM et al. (2008) Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin. Circ Res 103: 61-9 PubMed GONUTS page
  35. ↑ Li S et al. (2005) Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102: 1082-7 PubMed GONUTS page
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