MGI:Srebf1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3697282 PMID:17074803^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3760208 PMID:17636037^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:109128	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3760208 PMID:17636037^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:109128 MGI:MGI:1097691 MGI:MGI:1342774 MGI:MGI:1276533	P	From MGI
	GO:0003062	regulation of heart rate by chemical signal	MGI:MGI:3772404 PMID:18060044^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177773	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2159547 PMID:11829742^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:5294536 PMID:19244231^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3530682 PMID:15637161^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3697282 PMID:17074803^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:4359315 PMID:19564420^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3700436 PMID:16407292^[8]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P36956	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P36956	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2683822 PMID:14654692^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9D030	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3697282 PMID:17074803^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q3TUD7 UniProtKB:Q6DIC0 UniProtKB:P97496	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3760208 PMID:17636037^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P49698	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5315679 PMID:20817729^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q923E4	F	From MGI
	GO:0005634	nucleus	MGI:MGI:1927704 PMID:11090130^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P36956	C	From MGI
	GO:0005634	nucleus	MGI:MGI:5005039 PMID:21459323^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3603108 PMID:16100574^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005783	endoplasmic reticulum	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P36956	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0333	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2388133 PMID:12242332^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P36956	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:5005039 PMID:21459323^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0443	P	From MGI
	GO:0008202	steroid metabolic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0753	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	P	From MGI
	GO:0008286	insulin receptor signaling pathway	MGI:MGI:3697282 PMID:17074803^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008610	lipid biosynthetic process	MGI:MGI:5005039 PMID:21459323^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009267	cellular response to starvation	MGI:MGI:3700436 PMID:16407292^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009267	cellular response to starvation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:3778870 PMID:18178930^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177958	P	From MGI
	GO:0010867	positive regulation of triglyceride biosynthetic process	MGI:MGI:3603730 PMID:16046411^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177959	P	From MGI
	GO:0010867	positive regulation of triglyceride biosynthetic process	MGI:MGI:5294536 PMID:19244231^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016020	membrane	MGI:MGI:1927704 PMID:11090130^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0019217	regulation of fatty acid metabolic process	MGI:MGI:4359315 PMID:19564420^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4124835	P	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:5005039 PMID:21459323^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q5EG47 UniProtKB:Q8BRK8	F	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:5294536 PMID:19244231^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q60670	F	From MGI
	GO:0031065	positive regulation of histone deacetylation	MGI:MGI:3760208 PMID:17636037^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0968	C	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	F	From MGI
	GO:0032810	sterol response element binding	MGI:MGI:3700436 PMID:16407292^[8]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P36956	F	From MGI
	GO:0032810	sterol response element binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P36956	F	From MGI
	GO:0035104	positive regulation of transcription via sterol regulatory element binding	MGI:MGI:2177036 PMID:11739104^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043234	protein complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	C	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:2683822 PMID:14654692^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	F	From MGI
	GO:0044444	cytoplasmic part	MGI:MGI:5005039 PMID:21459323^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0045542	positive regulation of cholesterol biosynthetic process	MGI:MGI:1098057 PMID:9329978^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177958	P	From MGI
	GO:0045542	positive regulation of cholesterol biosynthetic process	MGI:MGI:3603730 PMID:16046411^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177959	P	From MGI
	GO:0045723	positive regulation of fatty acid biosynthetic process	MGI:MGI:1927704 PMID:11090130^[11]	TAS: Traceable Author Statement		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1927704 PMID:11090130^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P56720	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1098057 PMID:9329978^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2683822 PMID:14654692^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3697282 PMID:17074803^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3770077 PMID:16890542^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3772404 PMID:18060044^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P36956	P	From MGI
	GO:0046676	negative regulation of insulin secretion	MGI:MGI:3770077 PMID:16890542^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177773	P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:3778870 PMID:18178930^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177958	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lee YS et al. (2007) Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol Cell Biol 27: 438-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Ponugoti B et al. (2007) Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol 21: 2698-712 PubMed GONUTS page
↑ ^3.0 ^3.1 Park HJ et al. (2008) Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP. J Clin Invest 118: 259-71 PubMed GONUTS page
↑ Mallampalli RK et al. (2002) Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. Biochem J 362: 81-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yoon YS et al. (2009) Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation. J Biol Chem 284: 10446-52 PubMed GONUTS page
↑ Hegarty BD et al. (2005) Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc Natl Acad Sci U S A 102: 791-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Im SS et al. (2009) Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol 29: 4864-72 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Costet P et al. (2006) Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J Biol Chem 281: 6211-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lee YS et al. (2003) Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res 31: 7165-74 PubMed GONUTS page
↑ Ponugoti B et al. (2010) SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem 285: 33959-70 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Repa JJ et al. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 14: 2819-30 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Li Y et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13: 376-88 PubMed GONUTS page
↑ Engelking LJ et al. (2005) Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115: 2489-98 PubMed GONUTS page
↑ Yabe D et al. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A 99: 12753-8 PubMed GONUTS page
↑ ^15.0 ^15.1 Diraison F et al. (2008) SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing. J Lipid Res 49: 814-22 PubMed GONUTS page
↑ ^16.0 ^16.1 Jiang T et al. (2005) Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. J Biol Chem 280: 32317-25 PubMed GONUTS page
↑ Sone H et al. (2002) Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol Endocrinol Metab 282: E222-30 PubMed GONUTS page
↑ ^18.0 ^18.1 Shimano H et al. (1997) Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J Clin Invest 100: 2115-24 PubMed GONUTS page
↑ ^19.0 ^19.1 Kato T et al. (2006) Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab 4: 143-54 PubMed GONUTS page

[PMID:17074803-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lee YS et al. (2007) Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol Cell Biol 27: 438-52 PubMed GONUTS page

[PMID:17636037-1] 2.0 ^2.1 ^2.2 ^2.3 Ponugoti B et al. (2007) Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol 21: 2698-712 PubMed GONUTS page

[PMID:18060044-2] 3.0 ^3.1 Park HJ et al. (2008) Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP. J Clin Invest 118: 259-71 PubMed GONUTS page

[PMID:11829742-3] Mallampalli RK et al. (2002) Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. Biochem J 362: 81-8 PubMed GONUTS page

[PMID:19244231-4] 5.0 ^5.1 ^5.2 Yoon YS et al. (2009) Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation. J Biol Chem 284: 10446-52 PubMed GONUTS page

[PMID:15637161-5] Hegarty BD et al. (2005) Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc Natl Acad Sci U S A 102: 791-6 PubMed GONUTS page

[PMID:19564420-6] 7.0 ^7.1 Im SS et al. (2009) Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol 29: 4864-72 PubMed GONUTS page

[PMID:16407292-7] 8.0 ^8.1 ^8.2 Costet P et al. (2006) Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J Biol Chem 281: 6211-8 PubMed GONUTS page

[PMID:14654692-8] 9.0 ^9.1 ^9.2 Lee YS et al. (2003) Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res 31: 7165-74 PubMed GONUTS page

[PMID:20817729-9] Ponugoti B et al. (2010) SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem 285: 33959-70 PubMed GONUTS page

[PMID:11090130-10] 11.0 ^11.1 ^11.2 ^11.3 Repa JJ et al. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 14: 2819-30 PubMed GONUTS page

[PMID:21459323-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Li Y et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13: 376-88 PubMed GONUTS page

[PMID:16100574-12] Engelking LJ et al. (2005) Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115: 2489-98 PubMed GONUTS page

[PMID:12242332-13] Yabe D et al. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A 99: 12753-8 PubMed GONUTS page

[PMID:18178930-14] 15.0 ^15.1 Diraison F et al. (2008) SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing. J Lipid Res 49: 814-22 PubMed GONUTS page

[PMID:16046411-15] 16.0 ^16.1 Jiang T et al. (2005) Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. J Biol Chem 280: 32317-25 PubMed GONUTS page

[PMID:11739104-16] Sone H et al. (2002) Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol Endocrinol Metab 282: E222-30 PubMed GONUTS page

[PMID:9329978-17] 18.0 ^18.1 Shimano H et al. (1997) Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J Clin Invest 100: 2115-24 PubMed GONUTS page

[PMID:16890542-18] 19.0 ^19.1 Kato T et al. (2006) Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab 4: 143-54 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Srebf1 ( synonyms: ADD-1, bHLHd1, SREBP-1, SREBP-1a, SREBP-1c, SREBP1, SREBP1c )
Protein Name(s)	sterol regulatory element binding transcription factor 1,
External Links
MGI	MGI:107606

MGI:Srebf1

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