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MGI:Spn
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Spn ( synonyms: 3E8 antigen, Cd43, Galgp, leukosialin, Ly-48, Ly48 ) | |
| Protein Name(s) | sialophorin, | |
| External Links | ||
| MGI | MGI:98384 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001562 |
response to protozoan |
MGI:MGI:3029942 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001808 |
negative regulation of type IV hypersensitivity |
MGI:MGI:3029937 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0001931 |
uropod |
MGI:MGI:3029939 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001931 |
uropod |
MGI:MGI:3510555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2181857 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3510695 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:66056 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:3029939 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:3510555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005902 |
microvillus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0007162 |
negative regulation of cell adhesion |
MGI:MGI:3029938 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0007162 |
negative regulation of cell adhesion |
MGI:MGI:3029939 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007162 |
negative regulation of cell adhesion |
MGI:MGI:76803 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:73884 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008624 |
induction of apoptosis by extracellular signals |
MGI:MGI:1340173 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1860996 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3029936 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3029937 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3044274 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3510555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3510556 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3757615 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:66056 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:73884 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:74794 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:76803 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:77315 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:1340173 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:3029936 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:73884 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032154 |
cleavage furrow |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:3029936 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:73884 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042130 |
negative regulation of T cell proliferation |
MGI:MGI:3029937 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0042130 |
negative regulation of T cell proliferation |
MGI:MGI:3510556 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0042130 |
negative regulation of T cell proliferation |
MGI:MGI:76803 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0042535 |
positive regulation of tumor necrosis factor biosynthetic process |
MGI:MGI:1861065 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0042535 |
positive regulation of tumor necrosis factor biosynthetic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042742 |
defense response to bacterium |
MGI:MGI:1861065 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0042742 |
defense response to bacterium |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045060 |
negative thymic T cell selection |
MGI:MGI:1340173 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0050688 |
regulation of defense response to virus |
MGI:MGI:76803 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0050776 |
regulation of immune response |
MGI:MGI:3029937 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0050776 |
regulation of immune response |
MGI:MGI:76803 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0050868 |
negative regulation of T cell activation |
MGI:MGI:3029937 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
P |
From MGI |
||
| GO:0051635 |
bacterial cell surface binding |
MGI:MGI:1861065 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857246 |
F |
From MGI |
||
| GO:0051635 |
bacterial cell surface binding |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0071594 |
thymocyte aggregation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Todeschini AR et al. (2002) Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: involvement of CD43 signaling. J Immunol 168: 5192-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Thurman EC et al. (1998) Regulation of in vitro and in vivo T cell activation by CD43. Int Immunol 10: 691-701 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Savage ND et al. (2002) Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. J Immunol 168: 3740-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-50 PubMed GONUTS page
- ↑ Kikuchi S et al. (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet 31: 320-5 PubMed GONUTS page
- ↑ van den Berg TK et al. (2001) Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J Immunol 166: 3637-40 PubMed GONUTS page
- ↑ 7.0 7.1 Shiota J et al. (1994) A unique murine CD43 epitope Lp-3: distinct distribution from another CD43 epitope S7. Cell Immunol 155: 402-13 PubMed GONUTS page
- ↑ Fuzii HT & Travassos LR (2002) Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice. Melanoma Res 12: 9-16 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Manjunath N et al. (1995) Negative regulation of T-cell adhesion and activation by CD43. Nature 377: 535-8 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Sperling AI et al. (1995) CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med 182: 139-46 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Kishimoto H & Sprent J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J Exp Med 190: 65-73 PubMed GONUTS page
- ↑ Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-31 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Bagriacik EU et al. (2001) CD43 potentiates CD3-induced proliferation of murine intestinal intraepithelial lymphocytes. Immunol Cell Biol 79: 303-7 PubMed GONUTS page
- ↑ Garcia GG & Miller RA (2003) Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase. Eur J Immunol 33: 3464-72 PubMed GONUTS page
- ↑ 15.0 15.1 Tong J et al. (2004) CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism. J Exp Med 199: 1277-83 PubMed GONUTS page
- ↑ Chappel MS et al. (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med 184: 1639-49 PubMed GONUTS page
- ↑ Wenger RH et al. (1995) B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). Transgenic Res 4: 173-83 PubMed GONUTS page
- ↑ Cheng AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378: 303-6 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 Fratazzi C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med 192: 183-92 PubMed GONUTS page
