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MGI:Sphk2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sphk2 | |
| Protein Name(s) | sphingosine kinase 2, | |
| External Links | ||
| MGI | MGI:1861380 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001568 |
blood vessel development |
MGI:MGI:3610689 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1316649 |
P |
From MGI |
||
| GO:0004143 |
diacylglycerol kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3843433 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:1860308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0458 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:1860308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006669 |
sphinganine-1-phosphate biosynthetic process |
MGI:MGI:1860308 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0006670 |
sphingosine metabolic process |
MGI:MGI:3608224 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3580701 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:1860308 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0007205 |
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007420 |
brain development |
MGI:MGI:3610689 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1316649 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:1860308 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3610689 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1316649 |
P |
From MGI |
||
| GO:0008481 |
sphinganine kinase activity |
MGI:MGI:1860308 |
NAS: Non-traceable Author Statement |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0017050 |
D-erythro-sphingosine kinase activity |
MGI:MGI:1860308 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0017050 |
D-erythro-sphingosine kinase activity |
MGI:MGI:3608224 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3580701 |
F |
From MGI |
||
| GO:0046834 |
lipid phosphorylation |
MGI:MGI:1860308 |
NAS: Non-traceable Author Statement |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Mizugishi K et al. (2005) Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 25: 11113-21 PubMed GONUTS page
- ↑ Olivera A et al. (2006) IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J Biol Chem 281: 2515-25 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Liu H et al. (2000) Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 275: 19513-20 PubMed GONUTS page
- ↑ 4.0 4.1 Kharel Y et al. (2005) Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem 280: 36865-72 PubMed GONUTS page
