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MGI:Sp1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sp1 ( synonyms: Sp1-1 ) | |
| Protein Name(s) | trans-acting transcription factor 1, | |
| External Links | ||
| MGI | MGI:98372 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000978 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
MGI:MGI:5297791 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
MGI:MGI:3761912 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0000987 |
core promoter proximal region sequence-specific DNA binding |
MGI:MGI:4430122 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:4430122 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001103 |
RNA polymerase II repressing transcription factor binding |
MGI:MGI:5297791 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0001503 |
ossification |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0001829 |
trophectodermal cell differentiation |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0001892 |
embryonic placenta development |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1289810 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1861311 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2387736 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2684045 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3036942 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3039314 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3525914 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3575608 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3694414 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:79224 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:3513643 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2387736 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3513643 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3525914 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:50114 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1277036 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1861311 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2387736 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3045517 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3513643 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3581936 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3607044 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2387736 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030219 |
megakaryocyte differentiation |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0030324 |
lung development |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0032993 |
protein-DNA complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035035 |
histone acetyltransferase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0035326 |
enhancer binding |
MGI:MGI:1277036 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042826 |
histone deacetylase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043353 |
enucleate erythrocyte differentiation |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0043425 |
bHLH transcription factor binding |
MGI:MGI:5297791 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:1927252 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043923 |
positive regulation by host of viral transcription |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:2679136 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3513643 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3525914 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3575554 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106587 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:50114 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048596 |
embryonic camera-type eye morphogenesis |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0048706 |
embryonic skeletal system development |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0060136 |
embryonic process involved in female pregnancy |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0060216 |
definitive hemopoiesis |
MGI:MGI:3717030 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277166 |
P |
From MGI |
||
| GO:0071837 |
HMG box domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Azmi S et al. (2003) mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J Biol Chem 278: 20098-109 PubMed GONUTS page
- ↑ Yao D et al. (2007) High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem 282: 31038-45 PubMed GONUTS page
- ↑ 3.0 3.1 Morales-Lázaro SL et al. (2010) Induction of dystrophin Dp71 expression during neuronal differentiation: opposite roles of Sp1 and AP2alpha in Dp71 promoter activity. J Neurochem 112: 474-85 PubMed GONUTS page
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 Krüger I et al. (2007) Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects. Dev Dyn 236: 2235-44 PubMed GONUTS page
- ↑ Di Lisi R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem 273: 25371-80 PubMed GONUTS page
- ↑ 6.0 6.1 Izumi M et al. (2000) Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1. Biochim Biophys Acta 1492: 341-52 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Hadri L et al. (2002) Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1. J Biol Chem 277: 36471-8 PubMed GONUTS page
- ↑ Barski OA et al. (2004) Regulation of aldehyde reductase expression by STAF and CHOP. Genomics 83: 119-29 PubMed GONUTS page
- ↑ Giatzakis C & Papadopoulos V (2004) Differential utilization of the promoter of peripheral-type benzodiazepine receptor by steroidogenic versus nonsteroidogenic cell lines and the role of Sp1 and Sp3 in the regulation of basal activity. Endocrinology 145: 1113-23 PubMed GONUTS page
- ↑ Wu CX et al. (2004) Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein. Biochem Biophys Res Commun 317: 1096-102 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Luk JM et al. (2004) Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells. FEBS Lett 578: 251-6 PubMed GONUTS page
- ↑ Suske G et al. (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85: 551-6 PubMed GONUTS page
- ↑ Starzynski RR et al. (2006) STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide. Biochem J 400: 367-75 PubMed GONUTS page
- ↑ Rajput B et al. (1996) Transcriptional regulation of murine beta1,4-galactosyltransferase in somatic cells. Analysis of a gene that serves both a housekeeping and a mammary gland-specific function. J Biol Chem 271: 5131-42 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Subramanian SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol Biol Cell 15: 4532-43 PubMed GONUTS page
- ↑ 16.0 16.1 Nehls MC et al. (1992) NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. DNA Cell Biol 11: 443-52 PubMed GONUTS page
- ↑ 17.0 17.1 Collins M et al. (1998) A far upstream, cell type-specific enhancer of the mouse thrombospondin 3 gene is located within intron 6 of the adjacent metaxin gene. J Biol Chem 273: 21816-24 PubMed GONUTS page
- ↑ Suliman HB et al. (2004) Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood 104: 43-50 PubMed GONUTS page
- ↑ Wilmanski J et al. (2005) Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J Leukoc Biol 78: 85-94 PubMed GONUTS page
- ↑ Corbi N et al. (2005) RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. J Cell Sci 118: 4253-60 PubMed GONUTS page
- ↑ Harrison SM et al. (2000) Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury. Dev Biol 227: 358-72 PubMed GONUTS page
- ↑ Guermah M et al. (2003) The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol Cell 12: 991-1001 PubMed GONUTS page
- ↑ Matsui H et al. (2004) The mechanism of biogenesis and potential function of the two alternatively spliced mRNAs encoded by the murine Msx3 gene. Mol Cell Biochem 267: 1-11 PubMed GONUTS page
