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MGI:Sox2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sox2 ( synonyms: lcc, Sox-2, ysb ) | |
| Protein Name(s) | SRY-box containing gene 2, | |
| External Links | ||
| MGI | MGI:98364 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1270966 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101893 |
P |
From MGI |
||
| GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001102651 |
F |
From MGI |
||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001102651 |
F |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001708 |
cell fate specification |
MGI:MGI:2448211 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2449045 |
P |
From MGI |
||
| GO:0001714 |
endodermal cell fate specification |
MGI:MGI:4887279 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002052 |
positive regulation of neuroblast proliferation |
MGI:MGI:3051708 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181440 |
P |
From MGI |
||
| GO:0002052 |
positive regulation of neuroblast proliferation |
MGI:MGI:3624065 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3625176 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2654980 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3047455 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3589724 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101893 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:78983 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3582026 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1270030 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2654980 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3689142 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3694370 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:74891 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3577701 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3589724 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3718872 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3844410 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4457231 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4946164 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4946171 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:77200 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1201714 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2448211 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2654980 |
IC: Inferred by Curator |
GO:0003700 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3640906 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3689142 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3714586 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3718872 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3776980 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001102651 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4422111 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5285172 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:3718872 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2448211 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2654980 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:2181477 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2447996 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4887542 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4946164 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019827 |
stem cell maintenance |
MGI:MGI:3654397 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021879 |
forebrain neuron differentiation |
MGI:MGI:3051708 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181440 |
P |
From MGI |
||
| GO:0021984 |
adenohypophysis development |
MGI:MGI:3689142 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2449045 |
P |
From MGI |
||
| GO:0021987 |
cerebral cortex development |
MGI:MGI:3051708 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181440 |
P |
From MGI |
||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
MGI:MGI:3577701 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88276 |
P |
From MGI |
||
| GO:0030539 |
male genitalia development |
MGI:MGI:3689142 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2449045 |
P |
From MGI |
||
| GO:0030858 |
positive regulation of epithelial cell differentiation |
MGI:MGI:3795352 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030910 |
olfactory placode formation |
MGI:MGI:3701404 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101898 |
P |
From MGI |
||
| GO:0032526 |
response to retinoic acid |
MGI:MGI:3795829 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035019 |
somatic stem cell maintenance |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035198 |
miRNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042221 |
response to chemical stimulus |
MGI:MGI:3795829 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:3578496 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2447995 |
P |
From MGI |
||
| GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:1270030 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:1270966 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3795829 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4887279 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:74891 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043586 |
tongue development |
MGI:MGI:3664123 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3589809 |
P |
From MGI |
||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4422111 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4887547 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045165 |
cell fate commitment |
MGI:MGI:3795352 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:3718872 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3640906 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:3624065 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3625176 |
P |
From MGI |
||
| GO:0045668 |
negative regulation of osteoblast differentiation |
MGI:MGI:3577701 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045747 |
positive regulation of Notch signaling pathway |
MGI:MGI:3640906 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3582026 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3589724 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101893 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3689142 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3694370 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3694370 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101893 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3701404 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101898 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3718872 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3718872 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101893 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001102651 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4887279 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:74891 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:77200 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101893 |
P |
From MGI |
||
| GO:0046148 |
pigment biosynthetic process |
MGI:MGI:2181477 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2447996 |
P |
From MGI |
||
| GO:0048286 |
lung alveolus development |
MGI:MGI:3795352 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048568 |
embryonic organ development |
MGI:MGI:3714586 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3625175 |
P |
From MGI |
||
| GO:0048646 |
anatomical structure formation involved in morphogenesis |
MGI:MGI:1316886 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2135304 |
P |
From MGI |
||
| GO:0048646 |
anatomical structure formation involved in morphogenesis |
MGI:MGI:3714586 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3625175 |
P |
From MGI |
||
| GO:0048663 |
neuron fate commitment |
MGI:MGI:3664123 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3589809 |
P |
From MGI |
||
| GO:0048852 |
diencephalon morphogenesis |
MGI:MGI:3051708 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181440 |
P |
From MGI |
||
| GO:0048863 |
stem cell differentiation |
MGI:MGI:4422111 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050910 |
detection of mechanical stimulus involved in sensory perception of sound |
MGI:MGI:3578496 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2447995 |
P |
From MGI |
||
| GO:0050973 |
detection of mechanical stimulus involved in equilibrioception |
MGI:MGI:3578496 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2447995 |
P |
From MGI |
||
| GO:0060042 |
retina morphogenesis in camera-type eye |
MGI:MGI:3624065 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3625176 |
P |
From MGI |
||
| GO:0060235 |
lens induction in camera-type eye |
MGI:MGI:3701404 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101898 |
P |
From MGI |
||
| GO:0060441 |
epithelial tube branching involved in lung morphogenesis |
MGI:MGI:3795352 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070848 |
response to growth factor stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:3768575 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0097150 |
neuronal stem cell maintenance |
MGI:MGI:5306514 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Botquin V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev 12: 2073-90 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Avilion AA et al. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17: 126-40 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Teo AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev 25: 238-50 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Ferri AL et al. (2004) Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131: 3805-19 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Taranova OV et al. (2006) SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev 20: 1187-202 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Tokuzawa Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol 23: 2699-708 PubMed GONUTS page
- ↑ Murakami A et al. (2004) SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J Biol Chem 279: 28564-73 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Maruyama M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem 280: 24371-9 PubMed GONUTS page
- ↑ Collignon J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122: 509-20 PubMed GONUTS page
- ↑ 10.0 10.1 Chew JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25: 6031-46 PubMed GONUTS page
- ↑ 11.0 11.1 Johnson LR et al. (1998) Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. Mol Reprod Dev 50: 377-86 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 Kelberman D et al. (2006) Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. J Clin Invest 116: 2442-55 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Tsuruzoe S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun 351: 920-6 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Kamachi Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J 14: 3510-9 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Mansukhani A et al. (2005) Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol 168: 1065-76 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 16.5 Li J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J Biol Chem 282: 19481-92 PubMed GONUTS page
- ↑ Baltus GA et al. (2009) A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2. J Biol Chem 284: 6998-7006 PubMed GONUTS page
- ↑ Yu HB et al. (2009) Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem 284: 31327-35 PubMed GONUTS page
- ↑ 19.0 19.1 Johansson H & Simonsson S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2: 815-22 PubMed GONUTS page
- ↑ Karantzali E et al. (2011) Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem 286: 1037-45 PubMed GONUTS page
- ↑ 21.0 21.1 Yuan H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9: 2635-45 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
- ↑ Nishiguchi S et al. (1998) Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev 12: 776-81 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 Bani-Yaghoub M et al. (2006) Role of Sox2 in the development of the mouse neocortex. Dev Biol 295: 52-66 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 Que J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134: 2521-31 PubMed GONUTS page
- ↑ Fauquier T et al. (2008) SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A 105: 2907-12 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: 312-26 PubMed GONUTS page
- ↑ Haslinger A et al. (2009) Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci 29: 2103-14 PubMed GONUTS page
- ↑ 29.0 29.1 Dong S et al. (2002) Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics 79: 777-84 PubMed GONUTS page
- ↑ Wei Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27: 2969-78 PubMed GONUTS page
- ↑ Ivanova N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442: 533-8 PubMed GONUTS page
- ↑ 32.0 32.1 32.2 32.3 Gontan C et al. (2008) Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol 317: 296-309 PubMed GONUTS page
- ↑ 33.0 33.1 33.2 Donner AL et al. (2007) Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol 303: 784-99 PubMed GONUTS page
- ↑ 34.0 34.1 34.2 Kunarso G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9: 155 PubMed GONUTS page
- ↑ 35.0 35.1 35.2 Kiernan AE et al. (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature 434: 1031-5 PubMed GONUTS page
- ↑ 36.0 36.1 Okubo T et al. (2006) Sox2 is required for development of taste bud sensory cells. Genes Dev 20: 2654-9 PubMed GONUTS page
- ↑ Palasingam P et al. (2009) The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. J Mol Biol 388: 619-30 PubMed GONUTS page
- ↑ Tomihara-Newberger C et al. (1998) The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives. Dev Biol 204: 34-54 PubMed GONUTS page
- ↑ Sinner D et al. (2007) Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol 27: 7802-15 PubMed GONUTS page
- ↑ Andreu-Agullo C et al. (2011) Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature 481: 195-8 PubMed GONUTS page
