MGI:Sox18

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001525	angiogenesis	MGI:MGI:3664528 PMID:16895970^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:2179440 MGI:MGI:2178809	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:1355042 PMID:10742113^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856135	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:3849921 PMID:19429912^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856136	P	From MGI
	GO:0001570	vasculogenesis	MGI:MGI:3664529 PMID:16895968^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:2179440 MGI:MGI:2178809	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:1355042 PMID:10742113^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856135	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:3828192 PMID:18931657^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178809	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:3849921 PMID:19429912^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856136	P	From MGI
	GO:0001942	hair follicle development	MGI:MGI:1355042 PMID:10742113^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856135	P	From MGI
	GO:0001942	hair follicle development	MGI:MGI:1927721 PMID:11094083^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178809	P	From MGI
	GO:0001944	vasculature development	MGI:MGI:3849921 PMID:19429912^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856136	P	From MGI
	GO:0001945	lymph vessel development	MGI:MGI:3850578 PMID:19515696^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178809	P	From MGI
	GO:0001945	lymph vessel development	MGI:MGI:54697 PMID:291594^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856135	P	From MGI
	GO:0001946	lymphangiogenesis	MGI:MGI:3828192 PMID:18931657^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178809	P	From MGI
	GO:0001946	lymphangiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35713	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2449851 PMID:12446692^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:1355042 PMID:10742113^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2449851 PMID:12446692^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3033511 PMID:14634005^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:75639 PMID:7651823^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:5142376 PMID:11554755^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q8CFN5	F	From MGI
	GO:0005634	nucleus	MGI:MGI:2449851 PMID:12446692^[9]	IC: Inferred by Curator	GO:0003700	C	From MGI
	GO:0005634	nucleus	MGI:MGI:3828192 PMID:18931657^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35713	C	From MGI
	GO:0005634	nucleus	MGI:MGI:5142376 PMID:11554755^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2449851 PMID:12446692^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007507	heart development	MGI:MGI:1355042 PMID:10742113^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856135	P	From MGI
	GO:0022405	hair cycle process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35713	P	From MGI
	GO:0035050	embryonic heart tube development	MGI:MGI:3716256 PMID:17610846^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:107543	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:75639 PMID:7651823^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:3033511 PMID:14634005^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:3828192 PMID:18931657^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35713	F	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:3828192 PMID:18931657^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1355042 PMID:10742113^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1930851 PMID:11179689^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3033511 PMID:14634005^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3828192 PMID:18931657^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:5142376 PMID:11554755^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:75639 PMID:7651823^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35713	P	From MGI
	GO:0048469	cell maturation	MGI:MGI:4453910 PMID:20228271^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048866	stem cell fate specification	MGI:MGI:4453910 PMID:20228271^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060214	endocardium formation	MGI:MGI:3716256 PMID:17610846^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:107543	P	From MGI
	GO:0060836	lymphatic endothelial cell differentiation	MGI:MGI:3828192 PMID:18931657^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178809	P	From MGI
	GO:0060956	endocardial cell differentiation	MGI:MGI:3716256 PMID:17610846^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:107543	P	From MGI
	GO:0061028	establishment of endothelial barrier	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35713	P	From MGI
	GO:0072091	regulation of stem cell proliferation	MGI:MGI:4453910 PMID:20228271^[15]	IDA: Inferred from Direct Assay		P	From MGI
NOT	GO:0001701	in utero embryonic development	MGI:MGI:1927721 PMID:11094083^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178809	P	From MGI
NOT	GO:0007507	heart development	MGI:MGI:1927721 PMID:11094083^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178809	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Matsui T et al. (2006) Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci 119: 3513-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Pennisi D et al. (2000) Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet 24: 434-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Downes M et al. (2009) Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet 18: 2839-50 PubMed GONUTS page
↑ Swailes NT et al. (2006) Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse. J Cell Sci 119: 3561-70 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 François M et al. (2008) Sox18 induces development of the lymphatic vasculature in mice. Nature 456: 643-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Pennisi D et al. (2000) Mice null for sox18 are viable and display a mild coat defect. Mol Cell Biol 20: 9331-6 PubMed GONUTS page
↑ Hosking B et al. (2009) Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development 136: 2385-91 PubMed GONUTS page
↑ Wallace ME (1979) Analysis of genetic control of chylous ascites in ragged mice. Heredity (Edinb) 43: 9-18 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Hwang CK et al. (2003) Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J Biol Chem 278: 3742-50 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Hosking BM et al. (2004) The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18. J Biol Chem 279: 5314-22 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Hosking BM et al. (1995) Trans-activation and DNA-binding properties of the transcription factor, Sox-18. Nucleic Acids Res 23: 2626-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Hosking BM et al. (2001) SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun 287: 493-500 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Sakamoto Y et al. (2007) Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun 360: 539-44 PubMed GONUTS page
↑ Hosking BM et al. (2001) Cloning and functional analysis of the Sry-related HMG box gene, Sox18. Gene 262: 239-47 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Serrano AG et al. (2010) Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification. Blood 115: 3895-8 PubMed GONUTS page

[PMID:16895970-0] Matsui T et al. (2006) Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci 119: 3513-26 PubMed GONUTS page

[PMID:10742113-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Pennisi D et al. (2000) Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet 24: 434-7 PubMed GONUTS page

[PMID:19429912-2] 3.0 ^3.1 ^3.2 Downes M et al. (2009) Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet 18: 2839-50 PubMed GONUTS page

[PMID:16895968-3] Swailes NT et al. (2006) Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse. J Cell Sci 119: 3561-70 PubMed GONUTS page

[PMID:18931657-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 François M et al. (2008) Sox18 induces development of the lymphatic vasculature in mice. Nature 456: 643-7 PubMed GONUTS page

[PMID:11094083-5] 6.0 ^6.1 ^6.2 Pennisi D et al. (2000) Mice null for sox18 are viable and display a mild coat defect. Mol Cell Biol 20: 9331-6 PubMed GONUTS page

[PMID:19515696-6] Hosking B et al. (2009) Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development 136: 2385-91 PubMed GONUTS page

[PMID:291594-7] Wallace ME (1979) Analysis of genetic control of chylous ascites in ragged mice. Heredity (Edinb) 43: 9-18 PubMed GONUTS page

[PMID:12446692-8] 9.0 ^9.1 ^9.2 ^9.3 Hwang CK et al. (2003) Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J Biol Chem 278: 3742-50 PubMed GONUTS page

[PMID:14634005-9] 10.0 ^10.1 ^10.2 Hosking BM et al. (2004) The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18. J Biol Chem 279: 5314-22 PubMed GONUTS page

[PMID:7651823-10] 11.0 ^11.1 ^11.2 Hosking BM et al. (1995) Trans-activation and DNA-binding properties of the transcription factor, Sox-18. Nucleic Acids Res 23: 2626-8 PubMed GONUTS page

[PMID:11554755-11] 12.0 ^12.1 ^12.2 Hosking BM et al. (2001) SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun 287: 493-500 PubMed GONUTS page

[PMID:17610846-12] 13.0 ^13.1 ^13.2 Sakamoto Y et al. (2007) Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun 360: 539-44 PubMed GONUTS page

[PMID:11179689-13] Hosking BM et al. (2001) Cloning and functional analysis of the Sry-related HMG box gene, Sox18. Gene 262: 239-47 PubMed GONUTS page

[PMID:20228271-14] 15.0 ^15.1 ^15.2 Serrano AG et al. (2010) Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification. Blood 115: 3895-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Sox18 ( synonyms: Ragl, Sry-related HMG-box gene 18 )
Protein Name(s)	SRY-box containing gene 18,
External Links
MGI	MGI:103559

MGI:Sox18

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