MGI:Snai2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3774739 PMID:18223155^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08954	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0000790	nuclear chromatin	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	C	From MGI
	GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	MGI:MGI:3690827 PMID:16286009^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:98834	F	From MGI
	GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	MGI:MGI:3808643 PMID:18663143^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	F	From MGI
	GO:0001837	epithelial to mesenchymal transition	MGI:MGI:3762325 PMID:17916597^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447175	P	From MGI
	GO:0001837	epithelial to mesenchymal transition	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0001837	epithelial to mesenchymal transition	MGI:MGI:892810 PMID:9182671^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	MGI:MGI:3808643 PMID:18663143^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447175	P	From MGI
	GO:0003676	nucleic acid binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0238	F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3770601 PMID:17905753^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:3774739 PMID:18223155^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR007087 InterPro:IPR015880	C	From MGI
	GO:0005634	nucleus	MGI:MGI:2668295 PMID:12833143^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4418376 PMID:20046880^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4418376 PMID:20046880^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration	MGI:MGI:3808643 PMID:18663143^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447175	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007605	sensory perception of sound	MGI:MGI:2446014 PMID:12444107^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007605	sensory perception of sound	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0008270	zinc ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR007087 InterPro:IPR015880	F	From MGI
	GO:0009314	response to radiation	MGI:MGI:2668295 PMID:12833143^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009314	response to radiation	MGI:MGI:2668295 PMID:12833143^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447176	P	From MGI
	GO:0009790	embryo development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08954	P	From MGI
	GO:0010839	negative regulation of keratinocyte proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0010957	negative regulation of vitamin D biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0014032	neural crest cell development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0016477	cell migration	MGI:MGI:3709678 PMID:17376812^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:98330	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0032331	negative regulation of chondrocyte differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0032642	regulation of chemokine production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0035066	positive regulation of histone acetylation	MGI:MGI:3770601 PMID:17905753^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035414	negative regulation of catenin import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0035921	desmosome disassembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0035921	desmosome disassembly	MGI:MGI:892810 PMID:9182671^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:3690827 PMID:16286009^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:88138 MGI:MGI:98834	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0043473	pigmentation	MGI:MGI:2446014 PMID:12444107^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043473	pigmentation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	F	From MGI
	GO:0045600	positive regulation of fat cell differentiation	MGI:MGI:3770601 PMID:17905753^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:97747	P	From MGI
	GO:0045600	positive regulation of fat cell differentiation	MGI:MGI:3770601 PMID:17905753^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447176	P	From MGI
	GO:0045667	regulation of osteoblast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0045884	regulation of survival gene product expression	MGI:MGI:2668295 PMID:12833143^[7]	IC: Inferred by Curator	GO:0006355 GO:0009314	P	From MGI
	GO:0045885	positive regulation of survival gene product expression	MGI:MGI:5142392 PMID:10518215^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0050872	white fat cell differentiation	MGI:MGI:3770601 PMID:17905753^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447176	P	From MGI
	GO:0060021	palate development	MGI:MGI:3709678 PMID:17376812^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:98330	P	From MGI
	GO:0060021	palate development	MGI:MGI:3709678 PMID:17376812^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447176	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0060429	epithelium development	MGI:MGI:5284759 PMID:18716062^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060536	cartilage morphogenesis	MGI:MGI:3709678 PMID:17376812^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:98330	P	From MGI
	GO:0070563	negative regulation of vitamin D receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0071364	cellular response to epidermal growth factor stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:0071479	cellular response to ionizing radiation	MGI:MGI:3690827 PMID:16286009^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:2181667 MGI:MGI:98834	P	From MGI
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:2000647	negative regulation of stem cell proliferation	MGI:MGI:4436954 PMID:20032500^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447174	P	From MGI
	GO:2000810	regulation of tight junction assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
	GO:2000811	negative regulation of anoikis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O43623	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Roman AC et al. (2008) Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo. Proc Natl Acad Sci U S A 105: 1632-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Wu WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-53 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Niessen K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol 182: 315-25 PubMed GONUTS page
↑ Newkirk KM et al. (2007) Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis. Am J Pathol 171: 1629-39 PubMed GONUTS page
↑ ^5.0 ^5.1 Savagner P et al. (1997) The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 137: 1403-19 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Pérez-Mancera PA et al. (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum Mol Genet 16: 2972-86 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Pérez-Losada J et al. (2003) The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene 22: 4205-11 PubMed GONUTS page
↑ ^8.0 ^8.1 Bell CE & Watson AJ (2009) SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst. PLoS One 4: e8530 PubMed GONUTS page
↑ ^9.0 ^9.1 Sánchez-Martín M et al. (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet 11: 3231-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Murray SA et al. (2007) Multiple functions of Snail family genes during palate development in mice. Development 134: 1789-97 PubMed GONUTS page
↑ Inukai T et al. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell 4: 343-52 PubMed GONUTS page
↑ Arnoux V et al. (2008) Erk5 controls Slug expression and keratinocyte activation during wound healing. Mol Biol Cell 19: 4738-49 PubMed GONUTS page
↑ Sun Y et al. (2010) Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration. Blood 115: 1709-17 PubMed GONUTS page

[PMID:18223155-0] 1.0 ^1.1 Roman AC et al. (2008) Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo. Proc Natl Acad Sci U S A 105: 1632-7 PubMed GONUTS page

[PMID:16286009-1] 2.0 ^2.1 ^2.2 Wu WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-53 PubMed GONUTS page

[PMID:18663143-2] 3.0 ^3.1 ^3.2 Niessen K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol 182: 315-25 PubMed GONUTS page

[PMID:17916597-3] Newkirk KM et al. (2007) Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis. Am J Pathol 171: 1629-39 PubMed GONUTS page

[PMID:9182671-4] 5.0 ^5.1 Savagner P et al. (1997) The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 137: 1403-19 PubMed GONUTS page

[PMID:17905753-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Pérez-Mancera PA et al. (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum Mol Genet 16: 2972-86 PubMed GONUTS page

[PMID:12833143-6] 7.0 ^7.1 ^7.2 ^7.3 Pérez-Losada J et al. (2003) The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene 22: 4205-11 PubMed GONUTS page

[PMID:20046880-7] 8.0 ^8.1 Bell CE & Watson AJ (2009) SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst. PLoS One 4: e8530 PubMed GONUTS page

[PMID:12444107-8] 9.0 ^9.1 Sánchez-Martín M et al. (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet 11: 3231-6 PubMed GONUTS page

[PMID:17376812-9] 10.0 ^10.1 ^10.2 ^10.3 Murray SA et al. (2007) Multiple functions of Snail family genes during palate development in mice. Development 134: 1789-97 PubMed GONUTS page

[PMID:10518215-10] Inukai T et al. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell 4: 343-52 PubMed GONUTS page

[PMID:18716062-11] Arnoux V et al. (2008) Erk5 controls Slug expression and keratinocyte activation during wound healing. Mol Biol Cell 19: 4738-49 PubMed GONUTS page

[PMID:20032500-12] Sun Y et al. (2010) Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration. Blood 115: 1709-17 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Snai2 ( synonyms: Slug, Slugh, Snail2 )
Protein Name(s)	snail homolog 2 (Drosophila),
External Links
MGI	MGI:1096393

MGI:Snai2

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