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MGI:Smo
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Smo | |
| Protein Name(s) | smoothened homolog (Drosophila), | |
| External Links | ||
| MGI | MGI:108075 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3840017 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0001503 |
ossification |
MGI:MGI:2154465 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0001570 |
vasculogenesis |
MGI:MGI:3051693 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0001570 |
vasculogenesis |
MGI:MGI:3766861 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3036410 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3766861 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0001708 |
cell fate specification |
MGI:MGI:3806189 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0001755 |
neural crest cell migration |
MGI:MGI:3640718 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101791 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002052 |
positive regulation of neuroblast proliferation |
MGI:MGI:3619284 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88274 |
P |
From MGI |
||
| GO:0002053 |
positive regulation of mesenchymal cell proliferation |
MGI:MGI:3840017 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:3640718 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101791 |
P |
From MGI |
||
| GO:0003140 |
determination of left/right asymmetry in lateral mesoderm |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003323 |
type B pancreatic cell development |
MGI:MGI:4833770 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004888 |
transmembrane signaling receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004930 |
G-protein coupled receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0297 |
F |
From MGI |
||
| GO:0005113 |
patched binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:5306540 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005929 |
cilium |
MGI:MGI:3610248 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0297 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3040160 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3606828 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3686547 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3696007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934268 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:4833770 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:5285138 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007228 |
positive regulation of hh target transcription factor activity |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007283 |
spermatogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:2389012 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:3577662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2137553 |
P |
From MGI |
||
| GO:0007371 |
ventral midline determination |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007389 |
pattern specification process |
MGI:MGI:3040160 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0007417 |
central nervous system development |
MGI:MGI:2445271 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95729 |
P |
From MGI |
||
| GO:0007494 |
midgut development |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008144 |
drug binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008144 |
drug binding |
MGI:MGI:5285138 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:2429663 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3836883 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008406 |
gonad development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3577662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2137553 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3624182 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0010002 |
cardioblast differentiation |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3806189 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1341070 |
P |
From MGI |
||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:3611729 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:3611729 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0017147 |
Wnt-protein binding |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
F |
From MGI |
|||
| GO:0021508 |
floor plate formation |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0021561 |
facial nerve development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0021696 |
cerebellar cortex morphogenesis |
MGI:MGI:3624180 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0021904 |
dorsal/ventral neural tube patterning |
MGI:MGI:3806189 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0021910 |
smoothened signaling pathway involved in ventral spinal cord patterning |
MGI:MGI:3841503 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0021938 |
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation |
MGI:MGI:3624180 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0021953 |
central nervous system neuron differentiation |
MGI:MGI:3624182 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0021984 |
adenohypophysis development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
F |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030857 |
negative regulation of epithelial cell differentiation |
MGI:MGI:3696007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934268 |
P |
From MGI |
||
| GO:0031017 |
exocrine pancreas development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0031069 |
hair follicle morphogenesis |
MGI:MGI:3696007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934268 |
P |
From MGI |
||
| GO:0031076 |
embryonic camera-type eye development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0031102 |
neuron projection regeneration |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0032474 |
otolith morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0034504 |
protein localization to nucleus |
MGI:MGI:4398748 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035264 |
multicellular organism growth |
MGI:MGI:3806189 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1341070 |
P |
From MGI |
||
| GO:0035264 |
multicellular organism growth |
MGI:MGI:3806189 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0042307 |
positive regulation of protein import into nucleus |
MGI:MGI:3686547 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:2429663 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:3696007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934268 |
P |
From MGI |
||
| GO:0042693 |
muscle cell fate commitment |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0042813 |
Wnt-activated receptor activity |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
F |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
C |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3624182 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043392 |
negative regulation of DNA binding |
MGI:MGI:3611729 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95729 |
P |
From MGI |
||
| GO:0043392 |
negative regulation of DNA binding |
MGI:MGI:3611729 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0044294 |
dendritic growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0044295 |
axonal growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045880 |
positive regulation of smoothened signaling pathway |
MGI:MGI:3616743 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3580742 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3840017 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0048468 |
cell development |
MGI:MGI:2429663 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0048557 |
embryonic digestive tract morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0048565 |
digestive tract development |
MGI:MGI:4355651 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176255 |
P |
From MGI |
||
| GO:0048589 |
developmental growth |
MGI:MGI:3624182 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0048663 |
neuron fate commitment |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0048702 |
embryonic neurocranium morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0048703 |
embryonic viscerocranium morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0048752 |
semicircular canal morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0048846 |
axon extension involved in axon guidance |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048846 |
axon extension involved in axon guidance |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0048853 |
forebrain morphogenesis |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050679 |
positive regulation of epithelial cell proliferation |
MGI:MGI:3840017 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0050821 |
protein stabilization |
MGI:MGI:3836883 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051799 |
negative regulation of hair follicle development |
MGI:MGI:3696007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934268 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0060248 |
detection of cell density by contact stimulus involved in contact inhibition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060644 |
mammary gland epithelial cell differentiation |
MGI:MGI:3696007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934268 |
P |
From MGI |
||
| GO:0060684 |
epithelial-mesenchymal cell signaling |
MGI:MGI:3840017 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0060830 |
ciliary receptor clustering involved in smoothened signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0061053 |
somite development |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0061113 |
pancreas morphogenesis |
MGI:MGI:4833770 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176256 |
P |
From MGI |
||
| GO:0072285 |
mesenchymal to epithelial transition involved in metanephric renal vesicle formation |
MGI:MGI:3611729 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0072372 |
primary cilium |
MGI:MGI:3606828 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0090190 |
positive regulation of branching involved in ureteric bud morphogenesis |
MGI:MGI:3611729 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000036 |
regulation of stem cell maintenance |
MGI:MGI:3696007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934268 |
P |
From MGI |
||
| GO:2000826 |
regulation of heart morphogenesis |
MGI:MGI:5142377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Lan Y & Jiang R (2009) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136: 1387-96 PubMed GONUTS page
- ↑ Long F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-108 PubMed GONUTS page
- ↑ Vokes SA et al. (2004) Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131: 4371-80 PubMed GONUTS page
- ↑ 4.0 4.1 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page
- ↑ Long F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-18 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page
- ↑ 7.0 7.1 Lin L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol 295: 756-63 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-92 PubMed GONUTS page
- ↑ Lien WH et al. (2006) alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311: 1609-12 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Lau J & Hebrok M (2010) Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes 59: 1211-21 PubMed GONUTS page
- ↑ Bidet M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS One 6: e23834 PubMed GONUTS page
- ↑ May SR et al. (2005) Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol 287: 378-89 PubMed GONUTS page
- ↑ 13.0 13.1 Jeong J et al. (2004) Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 18: 937-51 PubMed GONUTS page
- ↑ 14.0 14.1 Corbit KC et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-21 PubMed GONUTS page
- ↑ 15.0 15.1 Kim JW & Lemke G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev 20: 2833-47 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 16.5 16.6 Gritli-Linde A et al. (2007) Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell 12: 99-112 PubMed GONUTS page
- ↑ 17.0 17.1 Roudaut H et al. (2011) Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol 79: 453-60 PubMed GONUTS page
- ↑ Kawakami T et al. (2002) Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development 129: 5753-65 PubMed GONUTS page
- ↑ 19.0 19.1 GarcÃa-GarcÃa MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page
- ↑ Wijgerde M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16: 2849-64 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Gritli-Linde A et al. (2002) Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129: 5323-37 PubMed GONUTS page
- ↑ 22.0 22.1 Wall DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 184: 101-12 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Blaess S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133: 1799-809 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 24.5 Hu MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-78 PubMed GONUTS page
- ↑ 25.0 25.1 Corrales JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133: 1811-21 PubMed GONUTS page
- ↑ Norman RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet 18: 1740-54 PubMed GONUTS page
- ↑ Fernandez-L A et al. (2009) YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev 23: 2729-41 PubMed GONUTS page
- ↑ Varjosalo M et al. (2006) Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell 10: 177-86 PubMed GONUTS page
- ↑ Lipinski RJ et al. (2005) Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev Dyn 233: 829-36 PubMed GONUTS page
- ↑ Spence JR et al. (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17: 62-74 PubMed GONUTS page
