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MGI:Smarca4

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Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Smarca4 ( synonyms: Brg1, SNF2beta, SW1/SNF )
Protein Name(s) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4,
External Links
MGI MGI:88192

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:3611125
PMID:16322236[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:3776329
PMID:18267097[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2450311

P

From MGI

GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0000790

nuclear chromatin

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

C

From MGI

GO:0000792

heterochromatin

MGI:MGI:3611125
PMID:16322236[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000902

cell morphogenesis

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933
MGI:MGI:2386105

P

From MGI

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

MGI:MGI:4454524
PMID:20176728[4]

IDA: Inferred from Direct Assay

F

From MGI

GO:0001570

vasculogenesis

MGI:MGI:3776329
PMID:18267097[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2450311

P

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933
MGI:MGI:2386105

P

From MGI

GO:0001832

blastocyst growth

MGI:MGI:1929360
PMID:11163203[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2386105

P

From MGI

GO:0001835

blastocyst hatching

MGI:MGI:1929360
PMID:11163203[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2386105

P

From MGI

GO:0001889

liver development

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933
MGI:MGI:2386105

P

From MGI

GO:0002039

p53 binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0003676

nucleic acid binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

From MGI

GO:0003677

DNA binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000330

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:1339222
PMID:10318760[6]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3610843
PMID:16287714[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3611125
PMID:16322236[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3697282
PMID:17074803[7]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3776329
PMID:18267097[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003713

transcription coactivator activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0003714

transcription corepressor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0004386

helicase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0347

F

From MGI

GO:0004386

helicase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

From MGI

GO:0005515

protein binding

MGI:MGI:2670837
PMID:12889071[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q921C3

F

From MGI

GO:0005515

protein binding

MGI:MGI:3610843
PMID:16287714[3]

IPI: Inferred from Physical Interaction

UniProtKB:A2BH40
UniProtKB:P97496
UniProtKB:O54941
UniProtKB:Q9Z0H3

F

From MGI

GO:0005515

protein binding

MGI:MGI:3611125
PMID:16322236[1]

IPI: Inferred from Physical Interaction

UniProtKB:O88508
UniProtKB:Q9Z2D8

F

From MGI

GO:0005515

protein binding

MGI:MGI:3775125
PMID:17640523[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9D8M7

F

From MGI

GO:0005515

protein binding

MGI:MGI:4887349
PMID:7923370[10]

IPI: Inferred from Physical Interaction

UniProtKB:P06400
UniProtKB:P13405

F

From MGI

GO:0005515

protein binding

MGI:MGI:5007924
PMID:19342595[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q9JM73
UniProtKB:B9EJ16

F

From MGI

GO:0005515

protein binding

MGI:MGI:5305502
PMID:22192413[12]

IPI: Inferred from Physical Interaction

UniProtKB:P79457

F

From MGI

GO:0005515

protein binding

MGI:MGI:5315365
PMID:12434308[13]

IPI: Inferred from Physical Interaction

UniProtKB:P06400

F

From MGI

GO:0005524

ATP binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From MGI

GO:0005524

ATP binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR014978
InterPro:IPR001650
InterPro:IPR000330

F

From MGI

GO:0005634

nucleus

MGI:MGI:1203262
PMID:9603422[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:1339222
PMID:10318760[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3528208
PMID:15565649[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3604915
PMID:16192310[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3653309
PMID:16880268[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3655410
PMID:16787967[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3776329
PMID:18267097[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_599195

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

C

From MGI

GO:0005719

nuclear euchromatin

MGI:MGI:1339222
PMID:10318760[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005726

perichromatin fibrils

MGI:MGI:1339222
PMID:10318760[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006200

ATP catabolic process

MGI:MGI:1929360
PMID:11163203[5]

TAS: Traceable Author Statement

P

From MGI

GO:0006334

nucleosome assembly

MGI:MGI:1929360
PMID:11163203[5]

TAS: Traceable Author Statement

P

From MGI

GO:0006337

nucleosome disassembly

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_599195

P

From MGI

GO:0006337

nucleosome disassembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0006338

chromatin remodeling

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933

P

From MGI

GO:0006338

chromatin remodeling

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0006346

methylation-dependent chromatin silencing

MGI:MGI:3611125
PMID:16322236[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR014978

P

From MGI

GO:0007399

nervous system development

MGI:MGI:3775125
PMID:17640523[9]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0007403

glial cell fate determination

MGI:MGI:3611670
PMID:16330018[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2176173

P

From MGI

GO:0007507

heart development

MGI:MGI:3776329
PMID:18267097[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2450311

P

From MGI

GO:0008094

DNA-dependent ATPase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0008134

transcription factor binding

MGI:MGI:3575864
PMID:15767674[20]

IPI: Inferred from Physical Interaction

UniProtKB:Q03267

F

From MGI

GO:0010424

DNA methylation on cytosine within a CG sequence

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933

P

From MGI

GO:0016514

SWI/SNF complex

MGI:MGI:1929360
PMID:11163203[5]

TAS: Traceable Author Statement

C

From MGI

GO:0016514

SWI/SNF complex

MGI:MGI:3610843
PMID:16287714[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016514

SWI/SNF complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_599195

C

From MGI

GO:0016514

SWI/SNF complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

C

From MGI

GO:0016568

chromatin modification

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

From MGI

GO:0016787

hydrolase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

From MGI

GO:0016817

hydrolase activity, acting on acid anhydrides

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006576

F

From MGI

GO:0016818

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR014978

F

From MGI

GO:0016887

ATPase activity

MGI:MGI:1929360
PMID:11163203[5]

TAS: Traceable Author Statement

F

From MGI

GO:0019827

stem cell maintenance

MGI:MGI:4454524
PMID:20176728[4]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0030198

extracellular matrix organization

MGI:MGI:3776329
PMID:18267097[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2450311

P

From MGI

GO:0030216

keratinocyte differentiation

MGI:MGI:3604915
PMID:16192310[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2177413

P

From MGI

GO:0030308

negative regulation of cell growth

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0030900

forebrain development

MGI:MGI:3611670
PMID:16330018[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2176173

P

From MGI

GO:0030902

hindbrain development

MGI:MGI:3611670
PMID:16330018[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2176173

P

From MGI

GO:0030957

Tat protein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0032403

protein complex binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_599195

F

From MGI

GO:0035116

embryonic hindlimb morphogenesis

MGI:MGI:3604915
PMID:16192310[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2177413

P

From MGI

GO:0035887

aortic smooth muscle cell differentiation

MGI:MGI:5007924
PMID:19342595[11]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043044

ATP-dependent chromatin remodeling

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_599195

P

From MGI

GO:0043388

positive regulation of DNA binding

MGI:MGI:5007924
PMID:19342595[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:2137495

P

From MGI

GO:0043923

positive regulation by host of viral transcription

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0043966

histone H3 acetylation

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:5007924
PMID:19342595[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:2137495

P

From MGI

GO:0047485

protein N-terminus binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0048562

embryonic organ morphogenesis

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933
MGI:MGI:2386105

P

From MGI

GO:0048730

epidermis morphogenesis

MGI:MGI:3604915
PMID:16192310[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3605892
MGI:MGI:2177413

P

From MGI

GO:0050681

androgen receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0060318

definitive erythrocyte differentiation

MGI:MGI:3610843
PMID:16287714[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611933

P

From MGI

GO:0060347

heart trabecula formation

MGI:MGI:3776329
PMID:18267097[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:109249

P

From MGI

GO:0060766

negative regulation of androgen receptor signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

P

From MGI

GO:0070577

histone acetyl-lysine binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

F

From MGI

GO:0071564

npBAF complex

MGI:MGI:3775125
PMID:17640523[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0071564

npBAF complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

C

From MGI

GO:0071565

nBAF complex

MGI:MGI:3775125
PMID:17640523[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0071778

WINAC complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P51532

C

From MGI

NOT

GO:0005730

nucleolus

MGI:MGI:1339222
PMID:10318760[6]

IDA: Inferred from Direct Assay

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Datta, J et al. (2005) Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. Cancer Res. 65 10891-900 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Stankunas, K et al. (2008) Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev. Cell 14 298-311 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Bultman, SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 19 2849-61 PubMed GONUTS page
  4. 4.0 4.1 Kidder, BL & Palmer, S (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20 458-72 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Bultman, S et al. (2000) A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol. Cell 6 1287-95 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Remboutsika, E et al. (1999) The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J. Cell. Sci. 112 ( Pt 11) 1671-83 PubMed GONUTS page
  7. Lee, YS et al. (2007) Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol. Cell. Biol. 27 438-52 PubMed GONUTS page
  8. Huang, H et al. (2003) Expression of the Wdr9 gene and protein products during mouse development. Dev. Dyn. 227 608-14 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Lessard, J et al. (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55 201-15 PubMed GONUTS page
  10. Dunaief, JL et al. (1994) The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79 119-30 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Zhou, J et al. (2009) The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression. Arterioscler. Thromb. Vasc. Biol. 29 921-8 PubMed GONUTS page
  12. Lee, S et al. (2012) UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev. Cell 22 25-37 PubMed GONUTS page
  13. Dunaief, JL et al. (2002) Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo. Curr. Eye Res. 24 392-6 PubMed GONUTS page
  14. LeGouy, E et al. (1998) Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein. Dev. Dyn. 212 38-48 PubMed GONUTS page
  15. Young, DW et al. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J. Cell. Biochem. 94 720-30 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 Indra, AK et al. (2005) Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation. Development 132 4533-44 PubMed GONUTS page
  17. Torres-Padilla, ME & Zernicka-Goetz, M (2006) Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J. Cell Biol. 174 329-38 PubMed GONUTS page
  18. Costa, Y et al. (2006) Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway? Hum. Mol. Genet. 15 2324-34 PubMed GONUTS page
  19. 19.0 19.1 19.2 Matsumoto, S et al. (2006) Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev. Biol. 289 372-83 PubMed GONUTS page
  20. Gómez-del Arco, P et al. (2005) Ikaros SUMOylation: switching out of repression. Mol. Cell. Biol. 25 2688-97 PubMed GONUTS page
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