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MGI:Slc9a3r1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Slc9a3r1 ( synonyms: EBP-50, NHE-RF, NHERF1, sodium-hydrogen exchanger regulatory factor ) | |
| Protein Name(s) | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1, | |
| External Links | ||
| MGI | MGI:1349482 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003096 |
renal sodium ion transport |
MGI:MGI:3702223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1345802 |
ISA: Inferred from Sequence Alignment |
EMBL:U19815 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3702223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:4819345 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067605 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005813 |
centrosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005902 |
microvillus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:4819345 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010642 |
negative regulation of platelet-derived growth factor receptor signaling pathway |
MGI:MGI:4943390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010766 |
negative regulation of sodium ion transport |
MGI:MGI:3702223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0014067 |
negative regulation of phosphatidylinositol 3-kinase cascade |
MGI:MGI:3617099 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97528 |
P |
From MGI |
||
| GO:0014067 |
negative regulation of phosphatidylinositol 3-kinase cascade |
MGI:MGI:3617099 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:4944038 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0879 |
P |
From MGI |
||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:2385526 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067605 |
C |
From MGI |
||
| GO:0017081 |
chloride channel regulator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019902 |
phosphatase binding |
MGI:MGI:3617099 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0019902 |
phosphatase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019902 |
phosphatase binding |
MGI:MGI:4943390 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0019933 |
cAMP-mediated signaling |
MGI:MGI:1345802 |
ISA: Inferred from Sequence Alignment |
EMBL:U19815 |
P |
From MGI |
||
| GO:0019933 |
cAMP-mediated signaling |
MGI:MGI:3702223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0030033 |
microvillus assembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030036 |
actin cytoskeleton organization |
MGI:MGI:3525780 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526430 |
P |
From MGI |
||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:3617099 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97528 |
P |
From MGI |
||
| GO:0030643 |
cellular phosphate ion homeostasis |
MGI:MGI:2385526 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0031526 |
brush border membrane |
MGI:MGI:3525780 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031528 |
microvillus membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067605 |
C |
From MGI |
||
| GO:0031698 |
beta-2 adrenergic receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032416 |
negative regulation of sodium:hydrogen antiporter activity |
MGI:MGI:3702223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0032782 |
bile acid secretion |
MGI:MGI:4834112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0034613 |
cellular protein localization |
MGI:MGI:3687116 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0034635 |
glutathione transport |
MGI:MGI:4834112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043621 |
protein self-association |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044062 |
regulation of excretion |
MGI:MGI:3687116 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0044062 |
regulation of excretion |
MGI:MGI:3692157 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0045177 |
apical part of cell |
MGI:MGI:3037476 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045859 |
regulation of protein kinase activity |
MGI:MGI:4943390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050780 |
dopamine receptor binding |
MGI:MGI:4819345 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0051898 |
negative regulation of protein kinase B signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051898 |
negative regulation of protein kinase B signaling cascade |
MGI:MGI:4943390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060158 |
activation of phospholipase C activity by dopamine receptor signaling pathway |
MGI:MGI:4819345 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386785 |
P |
From MGI |
||
| GO:0070293 |
renal absorption |
MGI:MGI:2385526 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070293 |
renal absorption |
MGI:MGI:3703405 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070851 |
growth factor receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0071944 |
cell periphery |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:2000146 |
negative regulation of cell motility |
MGI:MGI:3617099 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Weinman EJ et al. (2003) NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. FEBS Lett 536: 141-4 PubMed GONUTS page
- ↑ 2.0 2.1 Weinman EJ et al. (1999) Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. Biochim Biophys Acta 1447: 71-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Weinman EJ et al. (2010) Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. J Biol Chem 285: 13454-60 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Pan Y et al. (2008) Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Res 10: R5 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Takahashi Y et al. (2006) PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J 25: 910-20 PubMed GONUTS page
- ↑ Stokka AJ et al. (2009) The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T-cells and the immunomodulating effect of cAMP. Biochem J 425: 381-8 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Shenolikar S et al. (2002) Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A 99: 11470-5 PubMed GONUTS page
- ↑ 8.0 8.1 Morales FC et al. (2004) Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia. Proc Natl Acad Sci U S A 101: 17705-10 PubMed GONUTS page
- ↑ 9.0 9.1 Li M et al. (2010) NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem 285: 19299-307 PubMed GONUTS page
- ↑ 10.0 10.1 Weinman EJ et al. (2003) NHERF-1 is required for renal adaptation to a low-phosphate diet. Am J Physiol Renal Physiol 285: F1225-32 PubMed GONUTS page
- ↑ Weinman EJ et al. (2006) Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice. Am J Physiol Renal Physiol 290: F838-43 PubMed GONUTS page
- ↑ Gomperts BN et al. (2004) Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci 117: 1329-37 PubMed GONUTS page
- ↑ Capuano P et al. (2007) Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. Am J Physiol Cell Physiol 292: C927-34 PubMed GONUTS page
