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MGI:Ski
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ski | |
| Protein Name(s) | ski sarcoma viral oncogene homolog (avian), | |
| External Links | ||
| MGI | MGI:98310 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:75914 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97275 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:1095997 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0002089 |
lens morphogenesis in camera-type eye |
MGI:MGI:3693412 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0003682 |
chromatin binding |
MGI:MGI:3839724 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:102780 |
F |
From MGI |
||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2445270 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2445270 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3762994 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:70159 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:3839724 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2445270 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009948 |
anterior/posterior axis specification |
MGI:MGI:2176418 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0010626 |
negative regulation of Schwann cell proliferation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014902 |
myotube differentiation |
MGI:MGI:3762994 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0014902 |
myotube differentiation |
MGI:MGI:3839724 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:102780 |
P |
From MGI |
||
| GO:0014902 |
myotube differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016604 |
nuclear body |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016605 |
PML body |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0017053 |
transcriptional repressor complex |
MGI:MGI:2445270 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0021772 |
olfactory bulb development |
MGI:MGI:2176418 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0022011 |
myelination in peripheral nervous system |
MGI:MGI:3530938 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:2445270 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR10005 |
P |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR10005 |
P |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031064 |
negative regulation of histone deacetylation |
MGI:MGI:3762994 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97275 |
P |
From MGI |
||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032926 |
negative regulation of activin receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035019 |
somatic stem cell maintenance |
MGI:MGI:3850801 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:1095997 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0043010 |
camera-type eye development |
MGI:MGI:2176418 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0043388 |
positive regulation of DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043585 |
nose morphogenesis |
MGI:MGI:2176418 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0044428 |
nuclear part |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045668 |
negative regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3762994 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3839724 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:102780 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:75914 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:4459044 |
PANTHER:PTHR10005 |
F |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046811 |
histone deacetylase inhibitor activity |
MGI:MGI:3762994 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97275 |
F |
From MGI |
||
| GO:0048147 |
negative regulation of fibroblast proliferation |
MGI:MGI:2154995 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0048593 |
camera-type eye morphogenesis |
MGI:MGI:3693412 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0048741 |
skeletal muscle fiber development |
MGI:MGI:1095997 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0060021 |
palate development |
MGI:MGI:2176418 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0060041 |
retina development in camera-type eye |
MGI:MGI:3693412 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:1095997 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:2176418 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0060349 |
bone morphogenesis |
MGI:MGI:1095997 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177555 |
P |
From MGI |
||
| GO:0060395 |
SMAD protein signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070207 |
protein homotrimerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070491 |
repressing transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Engert JC et al. (1995) Activation of a muscle-specific enhancer by the Ski proto-oncogene. Nucleic Acids Res 23: 2988-94 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Berk M et al. (1997) Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. Genes Dev 11: 2029-39 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 McGannon P et al. (2006) Ocular abnormalities in mice lacking the Ski proto-oncogene. Invest Ophthalmol Vis Sci 47: 4231-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Zhang H & Stavnezer E (2009) Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3. J Biol Chem 284: 2867-79 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Dai P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev 16: 2843-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Kobayashi N et al. (2007) c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells 12: 375-85 PubMed GONUTS page
- ↑ Leferovich JM et al. (1995) Regulation of c-ski transgene expression in developing and mature mice. J Neurosci 15: 596-603 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Colmenares C et al. (2002) Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice. Nat Genet 30: 106-9 PubMed GONUTS page
- ↑ Atanasoski S et al. (2004) The protooncogene Ski controls Schwann cell proliferation and myelination. Neuron 43: 499-511 PubMed GONUTS page
- ↑ Deneault E et al. (2009) A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell 137: 369-79 PubMed GONUTS page
- ↑ Shinagawa T et al. (2001) Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice. Oncogene 20: 8100-8 PubMed GONUTS page
