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MGI:Shh

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Shh ( synonyms: Hhg1, Hx, Hxl3, M100081 )
Protein Name(s) sonic hedgehog,
External Links
MGI MGI:98297

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:1306711
PMID:9769173[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:1306711
PMID:9769173[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0001525

angiogenesis

MGI:MGI:3629544
PMID:16778080[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0001525

angiogenesis

MGI:MGI:3701403
PMID:17187775[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:95516

P

From MGI

GO:0001525

angiogenesis

MGI:MGI:3701403
PMID:17187775[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001569

patterning of blood vessels

MGI:MGI:3583396
PMID:15936751[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001570

vasculogenesis

MGI:MGI:3051693
PMID:15294868[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0001656

metanephros development

MGI:MGI:2388350
PMID:12399320[6]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0001658

branching involved in ureteric bud morphogenesis

MGI:MGI:3611729
PMID:16396903[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001708

cell fate specification

MGI:MGI:2387225
PMID:12231626[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001708

cell fate specification

MGI:MGI:3624618
PMID:16647304[9]

IGI: Inferred from Genetic Interaction

MGI:MGI:1926387

P

From MGI

GO:0001708

cell fate specification

MGI:MGI:3772421
PMID:18076286[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0001755

neural crest cell migration

MGI:MGI:3583396
PMID:15936751[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001822

kidney development

MGI:MGI:3664714
PMID:11172440[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001841

neural tube formation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0001942

hair follicle development

MGI:MGI:3589306
PMID:16054035[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001944

vasculature development

MGI:MGI:3766861
PMID:17881493[13]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0001947

heart looping

MGI:MGI:1340887
PMID:10411502[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001947

heart looping

MGI:MGI:1346236
PMID:10500184[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0001947

heart looping

MGI:MGI:5142377
PMID:11517919[16]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0001948

glycoprotein binding

MGI:MGI:2149274
PMID:11476578[17]

IDA: Inferred from Direct Assay

F

From MGI

GO:0002052

positive regulation of neuroblast proliferation

MGI:MGI:2154469
PMID:11748155[18]

IDA: Inferred from Direct Assay

P

From MGI

GO:0002052

positive regulation of neuroblast proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0002053

positive regulation of mesenchymal cell proliferation

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0002076

osteoblast development

MGI:MGI:3653954
PMID:16880529[20]

IDA: Inferred from Direct Assay

P

From MGI

GO:0002320

lymphoid progenitor cell differentiation

MGI:MGI:3029054
PMID:14764698[21]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0002320

lymphoid progenitor cell differentiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0003140

determination of left/right asymmetry in lateral mesoderm

MGI:MGI:5142377
PMID:11517919[16]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0004871

signal transducer activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

F

From MGI

GO:0005113

patched binding

MGI:MGI:1313055
PMID:9811851[22]

IPI: Inferred from Physical Interaction

UniProtKB:Q13635
UniProtKB:Q9Y6C5

F

From MGI

GO:0005113

patched binding

MGI:MGI:3687672
PMID:10500113[23]

IPI: Inferred from Physical Interaction

UniProtKB:Q61115

F

From MGI

GO:0005113

patched binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

F

From MGI

GO:0005509

calcium ion binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

F

From MGI

GO:0005515

protein binding

MGI:MGI:3687672
PMID:10500113[23]

IPI: Inferred from Physical Interaction

UniProtKB:Q61115

F

From MGI

GO:0005515

protein binding

MGI:MGI:3772109
PMID:18081866[24]

IPI: Inferred from Physical Interaction

UniProtKB:Q9D1G3

F

From MGI

GO:0005515

protein binding

MGI:MGI:4357747
PMID:19478089[25]

IPI: Inferred from Physical Interaction

UniProtKB:Q01721

F

From MGI

GO:0005515

protein binding

MGI:MGI:5285170
PMID:19561611[26]

IPI: Inferred from Physical Interaction

UniProtKB:Q96QV1

F

From MGI

GO:0005539

glycosaminoglycan binding

MGI:MGI:2149274
PMID:11476578[17]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005576

extracellular region

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

From MGI

GO:0005615

extracellular space

MGI:MGI:1329746
PMID:10027293[27]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:2150931
PMID:7891723[28]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

C

From MGI

GO:0005624

membrane fraction

MGI:MGI:3790551
PMID:18477453[29]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2156148
PMID:11724907[30]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005783

endoplasmic reticulum

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0005794

Golgi apparatus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1929969
PMID:11171399[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2136712
PMID:11412027[32]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0006508

proteolysis

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

From MGI

GO:0006508

proteolysis

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001767

P

From MGI

GO:0006897

endocytosis

MGI:MGI:3790551
PMID:18477453[29]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3820710
PMID:19029980[33]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

From MGI

GO:0007154

cell communication

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001657

P

From MGI

GO:0007165

signal transduction

MGI:MGI:2152294
PMID:11684660[34]

TAS: Traceable Author Statement

P

From MGI

GO:0007165

signal transduction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0007224

smoothened signaling pathway

MGI:MGI:1928592
PMID:11118883[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007224

smoothened signaling pathway

MGI:MGI:3051703
PMID:15269168[36]

IGI: Inferred from Genetic Interaction

MGI:MGI:1916147

P

From MGI

GO:0007224

smoothened signaling pathway

MGI:MGI:3686547
PMID:17043310[37]

IGI: Inferred from Genetic Interaction

MGI:MGI:108075

P

From MGI

GO:0007224

smoothened signaling pathway

MGI:MGI:84001
PMID:8906787[38]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007228

positive regulation of hh target transcription factor activity

MGI:MGI:1336531
PMID:10340755[39]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0007228

positive regulation of hh target transcription factor activity

MGI:MGI:3624046
PMID:16611981[40]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007228

positive regulation of hh target transcription factor activity

MGI:MGI:3653954
PMID:16880529[20]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

From MGI

GO:0007228

positive regulation of hh target transcription factor activity

MGI:MGI:5142377
PMID:11517919[16]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0007267

cell-cell signaling

MGI:MGI:3045497
PMID:15199404[41]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0007267

cell-cell signaling

MGI:MGI:3617552
PMID:16492970[42]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001657
InterPro:IPR000320

P

From MGI

GO:0007368

determination of left/right symmetry

MGI:MGI:1339521
PMID:10385121[43]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007368

determination of left/right symmetry

MGI:MGI:1340887
PMID:10411502[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007368

determination of left/right symmetry

MGI:MGI:1346236
PMID:10500184[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007389

pattern specification process

MGI:MGI:2387225
PMID:12231626[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007389

pattern specification process

MGI:MGI:2683891
PMID:14602680[44]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729

P

From MGI

GO:0007398

ectoderm development

MGI:MGI:1928592
PMID:11118883[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007405

neuroblast proliferation

MGI:MGI:3053236
PMID:15337776[45]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007411

axon guidance

MGI:MGI:2654974
PMID:12679031[46]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007411

axon guidance

MGI:MGI:2662556
PMID:12756179[47]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0007411

axon guidance

MGI:MGI:3628676
PMID:15065125[48]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0007417

central nervous system development

MGI:MGI:2445271
PMID:12435628[49]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0007442

hindgut morphogenesis

MGI:MGI:2148409
PMID:11485934[50]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007502

digestive tract mesoderm development

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0007507

heart development

MGI:MGI:1346236
PMID:10500184[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007507

heart development

MGI:MGI:3583396
PMID:15936751[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007507

heart development

MGI:MGI:3664714
PMID:11172440[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0007596

blood coagulation

MGI:MGI:79294
PMID:8835524[51]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1860897

P

From MGI

GO:0008209

androgen metabolic process

MGI:MGI:3037217
PMID:15013801[52]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0008219

cell death

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0008233

peptidase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

From MGI

GO:0008233

peptidase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001767

F

From MGI

GO:0008270

zinc ion binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

F

From MGI

GO:0008283

cell proliferation

MGI:MGI:3833793
PMID:19056373[53]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:2154469
PMID:11748155[18]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3051930
PMID:15183722[54]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:2387802

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3512837
PMID:15496441[55]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3589306
PMID:16054035[12]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3589306
PMID:16054035[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3608482
PMID:16236765[56]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:3052661

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3611729
PMID:16396903[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0009790

embryo development

MGI:MGI:3588476
PMID:16020517[57]

IGI: Inferred from Genetic Interaction

MGI:MGI:104719

P

From MGI

GO:0009790

embryo development

MGI:MGI:3766861
PMID:17881493[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0009952

anterior/posterior pattern specification

MGI:MGI:1928592
PMID:11118883[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0009952

anterior/posterior pattern specification

MGI:MGI:2135419
PMID:11389830[58]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387802

P

From MGI

GO:0009953

dorsal/ventral pattern formation

MGI:MGI:3051703
PMID:15269168[36]

IGI: Inferred from Genetic Interaction

MGI:MGI:1916147

P

From MGI

GO:0009986

cell surface

MGI:MGI:3511726
PMID:15576403[59]

IDA: Inferred from Direct Assay

C

From MGI

GO:0010463

mesenchymal cell proliferation

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0010468

regulation of gene expression

MGI:MGI:1329807
PMID:10021344[60]

ISO: Inferred from Sequence Orthology

UniProtKB:Q92008

P

From MGI

GO:0010468

regulation of gene expression

MGI:MGI:2149276
PMID:11476582[61]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0010468

regulation of gene expression

MGI:MGI:3822094
PMID:18799682[62]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729

P

From MGI

GO:0010468

regulation of gene expression

MGI:MGI:3822094
PMID:18799682[62]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0010628

positive regulation of gene expression

MGI:MGI:1928592
PMID:11118883[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0010628

positive regulation of gene expression

MGI:MGI:3611729
PMID:16396903[7]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0010629

negative regulation of gene expression

MGI:MGI:3611729
PMID:16396903[7]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0014003

oligodendrocyte development

MGI:MGI:81674
PMID:8660874[63]

IDA: Inferred from Direct Assay

P

From MGI

GO:0014706

striated muscle tissue development

MGI:MGI:1929969
PMID:11171399[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186

P

From MGI

GO:0014858

positive regulation of skeletal muscle cell proliferation

MGI:MGI:1929969
PMID:11171399[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186

P

From MGI

GO:0014902

myotube differentiation

MGI:MGI:1929969
PMID:11171399[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186
MGI:MGI:1857796

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016539

intein-mediated protein splicing

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006141

P

From MGI

GO:0021513

spinal cord dorsal/ventral patterning

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0021513

spinal cord dorsal/ventral patterning

MGI:MGI:2154468
PMID:11748151[64]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0021521

ventral spinal cord interneuron specification

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0021904

dorsal/ventral neural tube patterning

MGI:MGI:3710017
PMID:17442700[65]

IDA: Inferred from Direct Assay

P

From MGI

GO:0021904

dorsal/ventral neural tube patterning

MGI:MGI:3710451
PMID:17504941[66]

IGI: Inferred from Genetic Interaction

MGI:MGI:95655

P

From MGI

GO:0021904

dorsal/ventral neural tube patterning

MGI:MGI:3806189
PMID:18590716[67]

IDA: Inferred from Direct Assay

P

From MGI

GO:0021938

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

MGI:MGI:1338342
PMID:10375501[68]

IDA: Inferred from Direct Assay

P

From MGI

GO:0021938

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

MGI:MGI:1338342
PMID:10375501[68]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0021940

positive regulation of cerebellar granule cell precursor proliferation

MGI:MGI:1329746
PMID:10027293[27]

IDA: Inferred from Direct Assay

P

From MGI

GO:0021978

telencephalon regionalization

MGI:MGI:1926244
PMID:11060228[69]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0021978

telencephalon regionalization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0030010

establishment of cell polarity

MGI:MGI:3611172
PMID:16332353[70]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030133

transport vesicle

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0030162

regulation of proteolysis

MGI:MGI:3051935
PMID:15136151[71]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030177

positive regulation of Wnt receptor signaling pathway

MGI:MGI:2149936
PMID:11520664[72]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:1099602
PMID:9356179[73]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030323

respiratory tube development

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0030324

lung development

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0030324

lung development

MGI:MGI:1289788
PMID:9768363[74]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0030324

lung development

MGI:MGI:3050270
PMID:15305287[75]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:2679524

P

From MGI

GO:0030324

lung development

MGI:MGI:3051935
PMID:15136151[71]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729

P

From MGI

GO:0030324

lung development

MGI:MGI:3051935
PMID:15136151[71]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0030324

lung development

MGI:MGI:3701403
PMID:17187775[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0030326

embryonic limb morphogenesis

MGI:MGI:2135419
PMID:11389830[58]

IGI: Inferred from Genetic Interaction

MGI:MGI:105373

P

From MGI

GO:0030326

embryonic limb morphogenesis

MGI:MGI:2135419
PMID:11389830[58]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387802

P

From MGI

GO:0030326

embryonic limb morphogenesis

MGI:MGI:3053241
PMID:15315763[76]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3053959
MGI:MGI:3053960

P

From MGI

GO:0030326

embryonic limb morphogenesis

MGI:MGI:3851667
PMID:19422820[77]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729
MGI:MGI:97168
MGI:MGI:97169

P

From MGI

GO:0030336

negative regulation of cell migration

MGI:MGI:3053236
PMID:15337776[45]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030424

axon

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0030425

dendrite

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0030539

male genitalia development

MGI:MGI:2152294
PMID:11684660[34]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0030850

prostate gland development

MGI:MGI:1335656
PMID:10208740[78]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0030850

prostate gland development

MGI:MGI:3037217
PMID:15013801[52]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0030878

thyroid gland development

MGI:MGI:3702792
PMID:16968815[79]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186

P

From MGI

GO:0030900

forebrain development

MGI:MGI:3588476
PMID:16020517[57]

IGI: Inferred from Genetic Interaction

MGI:MGI:104719

P

From MGI

GO:0030901

midbrain development

MGI:MGI:3588476
PMID:16020517[57]

IGI: Inferred from Genetic Interaction

MGI:MGI:104719

P

From MGI

GO:0030902

hindbrain development

MGI:MGI:3051930
PMID:15183722[54]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:2387802

P

From MGI

GO:0030902

hindbrain development

MGI:MGI:3512837
PMID:15496441[55]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

From MGI

GO:0031012

extracellular matrix

MGI:MGI:2149274
PMID:11476578[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031016

pancreas development

MGI:MGI:1858523
PMID:10821773[80]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0031016

pancreas development

MGI:MGI:1926239
PMID:11044404[81]

IGI: Inferred from Genetic Interaction

MGI:MGI:96533

P

From MGI

GO:0031016

pancreas development

MGI:MGI:1926239
PMID:11044404[81]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0031069

hair follicle morphogenesis

MGI:MGI:1289785
PMID:9768360[82]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0031069

hair follicle morphogenesis

MGI:MGI:2149936
PMID:11520664[72]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0031069

hair follicle morphogenesis

MGI:MGI:2681050
PMID:14623238[83]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

MGI:MGI:3624046
PMID:16611981[40]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0032880

regulation of protein localization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0033077

T cell differentiation in thymus

MGI:MGI:3847177
PMID:19273836[84]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0033089

positive regulation of T cell differentiation in thymus

MGI:MGI:3836494
PMID:19109233[85]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0033092

positive regulation of immature T cell proliferation in thymus

MGI:MGI:3029054
PMID:14764698[21]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0033092

positive regulation of immature T cell proliferation in thymus

MGI:MGI:3847177
PMID:19273836[84]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0034244

negative regulation of transcription elongation from RNA polymerase II promoter

MGI:MGI:3703195
PMID:17284610[86]

IDA: Inferred from Direct Assay

P

From MGI

GO:0034504

protein localization to nucleus

MGI:MGI:4398748
PMID:19952108[87]

IDA: Inferred from Direct Assay

P

From MGI

GO:0035115

embryonic forelimb morphogenesis

MGI:MGI:1928592
PMID:11118883[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0035115

embryonic forelimb morphogenesis

MGI:MGI:2149276
PMID:11476582[61]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0035116

embryonic hindlimb morphogenesis

MGI:MGI:1928592
PMID:11118883[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:2662556
PMID:12756179[47]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0042130

negative regulation of T cell proliferation

MGI:MGI:1888832
PMID:10981962[88]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0042177

negative regulation of protein catabolic process

MGI:MGI:3624046
PMID:16611981[40]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0042307

positive regulation of protein import into nucleus

MGI:MGI:3686547
PMID:17043310[37]

IGI: Inferred from Genetic Interaction

MGI:MGI:108075

P

From MGI

GO:0042475

odontogenesis of dentin-containing tooth

MGI:MGI:1926240
PMID:11044393[89]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:2445832

P

From MGI

GO:0042476

odontogenesis

MGI:MGI:1855801
PMID:10781055[90]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042733

embryonic digit morphogenesis

MGI:MGI:3579954
PMID:15930098[91]

IGI: Inferred from Genetic Interaction

MGI:MGI:98715

P

From MGI

GO:0042733

embryonic digit morphogenesis

MGI:MGI:3710451
PMID:17504941[66]

IGI: Inferred from Genetic Interaction

MGI:MGI:95655

P

From MGI

GO:0042733

embryonic digit morphogenesis

MGI:MGI:3710452
PMID:17504940[92]

IGI: Inferred from Genetic Interaction

MGI:MGI:95655

P

From MGI

GO:0042981

regulation of apoptotic process

MGI:MGI:3851667
PMID:19422820[77]

IGI: Inferred from Genetic Interaction

MGI:MGI:97169
MGI:MGI:97168

P

From MGI

GO:0043010

camera-type eye development

MGI:MGI:2385969
PMID:12195432[93]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043010

camera-type eye development

MGI:MGI:2662556
PMID:12756179[47]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0043010

camera-type eye development

MGI:MGI:3608482
PMID:16236765[56]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:3052661

P

From MGI

GO:0043010

camera-type eye development

MGI:MGI:3807419
PMID:18582859[94]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729

P

From MGI

GO:0043025

neuronal cell body

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0043237

laminin-1 binding

MGI:MGI:3573843
PMID:15056720[95]

IDA: Inferred from Direct Assay

F

From MGI

GO:0043369

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

MGI:MGI:3834308
PMID:17227833[96]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043369

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0043586

tongue development

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0043587

tongue morphogenesis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0043588

skin development

MGI:MGI:1336614
PMID:10331973[97]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0045059

positive thymic T cell selection

MGI:MGI:3834308
PMID:17227833[96]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045060

negative thymic T cell selection

MGI:MGI:3834308
PMID:17227833[96]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045109

intermediate filament organization

MGI:MGI:1929969
PMID:11171399[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186

P

From MGI

GO:0045121

membrane raft

MGI:MGI:3039193
PMID:15075292[98]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045121

membrane raft

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

C

From MGI

GO:0045165

cell fate commitment

MGI:MGI:3710451
PMID:17504941[66]

IGI: Inferred from Genetic Interaction

MGI:MGI:95655

P

From MGI

GO:0045445

myoblast differentiation

MGI:MGI:3621570
PMID:15238161[99]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045471

response to ethanol

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0045596

negative regulation of cell differentiation

MGI:MGI:3053236
PMID:15337776[45]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045596

negative regulation of cell differentiation

MGI:MGI:3608482
PMID:16236765[56]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:3052661

P

From MGI

GO:0045597

positive regulation of cell differentiation

MGI:MGI:1337447
PMID:10357934[100]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045666

positive regulation of neuron differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0045880

positive regulation of smoothened signaling pathway

MGI:MGI:5142377
PMID:11517919[16]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:1099602
PMID:9356179[73]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:2388350
PMID:12399320[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1205964
PMID:9585504[101]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1205964
PMID:9585504[101]

IGI: Inferred from Genetic Interaction

MGI:MGI:104327

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1306711
PMID:9769173[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1306711
PMID:9769173[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1336531
PMID:10340755[39]

IGI: Inferred from Genetic Interaction

MGI:MGI:97168

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:1336531
PMID:10340755[39]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:2135612
PMID:11493558[102]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3653954
PMID:16880529[20]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3766861
PMID:17881493[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:96533

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3840017
PMID:19304890[103]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:85754
PMID:9006067[104]

IDA: Inferred from Direct Assay

P

From MGI

GO:0046534

positive regulation of photoreceptor cell differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0046638

positive regulation of alpha-beta T cell differentiation

MGI:MGI:3029054
PMID:14764698[21]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0046639

negative regulation of alpha-beta T cell differentiation

MGI:MGI:1888832
PMID:10981962[88]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048468

cell development

MGI:MGI:3051930
PMID:15183722[54]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:2387802

P

From MGI

GO:0048468

cell development

MGI:MGI:3608482
PMID:16236765[56]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:3052661

P

From MGI

GO:0048538

thymus development

MGI:MGI:3836494
PMID:19109233[85]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048546

digestive tract morphogenesis

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048557

embryonic digestive tract morphogenesis

MGI:MGI:1858523
PMID:10821773[80]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0048557

embryonic digestive tract morphogenesis

MGI:MGI:5306328
PMID:11001584[105]

TAS: Traceable Author Statement

P

From MGI

GO:0048568

embryonic organ development

MGI:MGI:3612368
PMID:15680353[106]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048589

developmental growth

MGI:MGI:1926240
PMID:11044393[89]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:2445832

P

From MGI

GO:0048598

embryonic morphogenesis

MGI:MGI:3617552
PMID:16492970[42]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048598

embryonic morphogenesis

MGI:MGI:3766861
PMID:17881493[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048617

embryonic foregut morphogenesis

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048617

embryonic foregut morphogenesis

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048643

positive regulation of skeletal muscle tissue development

MGI:MGI:1929969
PMID:11171399[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186
MGI:MGI:1857796

P

From MGI

GO:0048645

organ formation

MGI:MGI:3037217
PMID:15013801[52]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048646

anatomical structure formation involved in morphogenesis

MGI:MGI:1289788
PMID:9768363[74]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0048663

neuron fate commitment

MGI:MGI:3608263
PMID:16221724[107]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0048678

response to axon injury

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0048706

embryonic skeletal system development

MGI:MGI:3710451
PMID:17504941[66]

IGI: Inferred from Genetic Interaction

MGI:MGI:95655

P

From MGI

GO:0048709

oligodendrocyte differentiation

MGI:MGI:1929974
PMID:11171336[108]

IGI: Inferred from Genetic Interaction

MGI:MGI:108067

P

From MGI

GO:0048709

oligodendrocyte differentiation

MGI:MGI:2138067
PMID:11493571[109]

IGI: Inferred from Genetic Interaction

MGI:MGI:108067

P

From MGI

GO:0048709

oligodendrocyte differentiation

MGI:MGI:3703379
PMID:15880651[110]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729

P

From MGI

GO:0048714

positive regulation of oligodendrocyte differentiation

MGI:MGI:1929974
PMID:11171336[108]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048754

branching morphogenesis of a tube

MGI:MGI:1289788
PMID:9768363[74]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0048754

branching morphogenesis of a tube

MGI:MGI:3039063
PMID:15042696[111]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048754

branching morphogenesis of a tube

MGI:MGI:3050270
PMID:15305287[75]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268
MGI:MGI:2679524

P

From MGI

GO:0048808

male genitalia morphogenesis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0048839

inner ear development

MGI:MGI:3709667
PMID:17395647[112]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729

P

From MGI

GO:0048839

inner ear development

MGI:MGI:3709667
PMID:17395647[112]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934261

P

From MGI

GO:0048856

anatomical structure development

MGI:MGI:2148409
PMID:11485934[50]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048859

formation of anatomical boundary

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0048864

stem cell development

MGI:MGI:2667422
PMID:12843296[113]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051146

striated muscle cell differentiation

MGI:MGI:3621570
PMID:15238161[99]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051146

striated muscle cell differentiation

MGI:MGI:3621570
PMID:15238161[99]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0051155

positive regulation of striated muscle cell differentiation

MGI:MGI:1929969
PMID:11171399[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186
MGI:MGI:1857796

P

From MGI

GO:0051781

positive regulation of cell division

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0060020

Bergmann glial cell differentiation

MGI:MGI:1338342
PMID:10375501[68]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060021

palate development

MGI:MGI:3840017
PMID:19304890[103]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0060021

palate development

MGI:MGI:3840017
PMID:19304890[103]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176256

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3703195
PMID:17284610[86]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060173

limb development

MGI:MGI:3841513
PMID:19223390[114]

IGI: Inferred from Genetic Interaction

MGI:MGI:1329045

P

From MGI

GO:0060173

limb development

MGI:MGI:3841513
PMID:19223390[114]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060174

limb bud formation

MGI:MGI:1928592
PMID:11118883[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060406

positive regulation of penile erection

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0060425

lung morphogenesis

MGI:MGI:1346236
PMID:10500184[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060428

lung epithelium development

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060438

trachea development

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060439

trachea morphogenesis

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060441

epithelial tube branching involved in lung morphogenesis

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060441

epithelial tube branching involved in lung morphogenesis

MGI:MGI:1346236
PMID:10500184[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060442

branching involved in prostate gland morphogenesis

MGI:MGI:1335656
PMID:10208740[78]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060445

branching involved in salivary gland morphogenesis

MGI:MGI:3039063
PMID:15042696[111]

IGI: Inferred from Genetic Interaction

MGI:MGI:99604

P

From MGI

GO:0060445

branching involved in salivary gland morphogenesis

MGI:MGI:3039063
PMID:15042696[111]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060447

bud outgrowth involved in lung branching

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060458

right lung development

MGI:MGI:1346236
PMID:10500184[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060459

left lung development

MGI:MGI:1346236
PMID:10500184[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060463

lung lobe morphogenesis

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060484

lung-associated mesenchyme development

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0060516

primary prostatic bud elongation

MGI:MGI:1335656
PMID:10208740[78]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060523

prostate epithelial cord elongation

MGI:MGI:3037217
PMID:15013801[52]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060662

salivary gland cavitation

MGI:MGI:3611172
PMID:16332353[70]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060664

epithelial cell proliferation involved in salivary gland morphogenesis

MGI:MGI:3039063
PMID:15042696[111]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060684

epithelial-mesenchymal cell signaling

MGI:MGI:3840017
PMID:19304890[103]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934268

P

From MGI

GO:0060685

regulation of prostatic bud formation

MGI:MGI:2386799
PMID:12221011[115]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060685

regulation of prostatic bud formation

MGI:MGI:3785350
PMID:18393306[116]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060738

epithelial-mesenchymal signaling involved in prostate gland development

MGI:MGI:2386799
PMID:12221011[115]

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0060738

epithelial-mesenchymal signaling involved in prostate gland development

MGI:MGI:3603077
PMID:15987773[117]

IGI: Inferred from Genetic Interaction

MGI:MGI:1347472

P

From MGI

GO:0060768

regulation of epithelial cell proliferation involved in prostate gland development

MGI:MGI:2386799
PMID:12221011[115]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060769

positive regulation of epithelial cell proliferation involved in prostate gland development

MGI:MGI:2386799
PMID:12221011[115]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060782

regulation of mesenchymal cell proliferation involved in prostate gland development

MGI:MGI:2386799
PMID:12221011[115]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060783

mesenchymal smoothened signaling pathway involved in prostate gland development

MGI:MGI:2386799
PMID:12221011[115]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060840

artery development

MGI:MGI:3702792
PMID:16968815[79]

IGI: Inferred from Genetic Interaction

MGI:MGI:95729

P

From MGI

GO:0060840

artery development

MGI:MGI:3702792
PMID:16968815[79]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861186

P

From MGI

GO:0060916

mesenchymal cell proliferation involved in lung development

MGI:MGI:85754
PMID:9006067[104]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060979

vasculogenesis involved in coronary vascular morphogenesis

MGI:MGI:4943617
PMID:20299672[118]

TAS: Traceable Author Statement

P

From MGI

GO:0061053

somite development

MGI:MGI:5142377
PMID:11517919[16]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0061189

positive regulation of sclerotome development

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15465

P

From MGI

GO:0061196

fungiform papilla development

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0061197

fungiform papilla morphogenesis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0061198

fungiform papilla formation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0070447

positive regulation of oligodendrocyte progenitor proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63673

P

From MGI

GO:0071285

cellular response to lithium ion

MGI:MGI:3703195
PMID:17284610[86]

IDA: Inferred from Direct Assay

P

From MGI

GO:0072136

metanephric mesenchymal cell proliferation involved in metanephros development

MGI:MGI:2388350
PMID:12399320[6]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0080125

multicellular structure septum development

MGI:MGI:1277744
PMID:9731532[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857796

P

From MGI

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

MGI:MGI:3703195
PMID:17284610[86]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0090370

negative regulation of cholesterol efflux

MGI:MGI:5306540
PMID:21931618[119]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:2000062

negative regulation of ureter smooth muscle cell differentiation

MGI:MGI:2388350
PMID:12399320[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:2000063

positive regulation of ureter smooth muscle cell differentiation

MGI:MGI:2388350
PMID:12399320[6]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:2000357

negative regulation of kidney smooth muscle cell differentiation

MGI:MGI:2388350
PMID:12399320[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:2000358

positive regulation of kidney smooth muscle cell differentiation

MGI:MGI:2388350
PMID:12399320[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:2000729

positive regulation of mesenchymal cell proliferation involved in ureter development

MGI:MGI:2388350
PMID:12399320[6]

IMP: Inferred from Mutant Phenotype

P

From MGI

NOT

GO:0016787

hydrolase activity

MGI:MGI:3687672
PMID:10500113[23]

IDA: Inferred from Direct Assay

F

From MGI

NOT

GO:0060513

prostatic bud formation

MGI:MGI:3037217
PMID:15013801[52]

IGI: Inferred from Genetic Interaction

MGI:MGI:88064

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 Dassule HR & McMahon AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol 202: 215-27 PubMed GONUTS page
  2. ↑ Lavine KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev 20: 1651-66 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 van Tuyl M et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev Biol 303: 514-26 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Washington Smoak I et al. (2005) Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. Dev Biol 283: 357-72 PubMed GONUTS page
  5. ↑ Vokes SA et al. (2004) Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131: 4371-80 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Yu J et al. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129: 5301-12 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Hu MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-78 PubMed GONUTS page
  8. ↑ 8.0 8.1 Riccomagno MM et al. (2002) Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev 16: 2365-78 PubMed GONUTS page
  9. ↑ Tenzen T et al. (2006) The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 10: 647-56 PubMed GONUTS page
  10. ↑ Kittappa R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5: e325 PubMed GONUTS page
  11. ↑ 11.0 11.1 Kim PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J Pediatr Surg 36: 381-4 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Mill P et al. (2005) Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell 9: 293-303 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page
  14. ↑ 14.0 14.1 Meyers EN & Martin GR (1999) Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285: 403-6 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 15.3 15.4 15.5 15.6 Tsukui T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A 96: 11376-81 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 16.3 16.4 Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-92 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 Gritli-Linde A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol 236: 364-86 PubMed GONUTS page
  18. ↑ 18.0 18.1 Dahmane N et al. (2001) The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 128: 5201-12 PubMed GONUTS page
  19. ↑ 19.00 19.01 19.02 19.03 19.04 19.05 19.06 19.07 19.08 19.09 19.10 19.11 19.12 19.13 19.14 19.15 19.16 19.17 Litingtung Y et al. (1998) Sonic hedgehog is essential to foregut development. Nat Genet 20: 58-61 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 Zhao M et al. (2006) The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol 26: 6197-208 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Shah DK et al. (2004) Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol 172: 2296-306 PubMed GONUTS page
  22. ↑ Carpenter D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A 95: 13630-4 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 Fuse N et al. (1999) Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci U S A 96: 10992-9 PubMed GONUTS page
  24. ↑ Abe Y et al. (2008) Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog. FEBS J 275: 318-31 PubMed GONUTS page
  25. ↑ Martinelli DC & Fan CM (2009) A sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1. J Biol Chem 284: 19169-72 PubMed GONUTS page
  26. ↑ Bishop B et al. (2009) Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. Nat Struct Mol Biol 16: 698-703 PubMed GONUTS page
  27. ↑ 27.0 27.1 Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page
  28. ↑ Bumcrot DA et al. (1995) Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol 15: 2294-303 PubMed GONUTS page
  29. ↑ 29.0 29.1 Capurro MI et al. (2008) Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell 14: 700-11 PubMed GONUTS page
  30. ↑ Miller LA et al. (2001) Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J Histochem Cytochem 49: 1593-604 PubMed GONUTS page
  31. ↑ 31.0 31.1 31.2 31.3 31.4 31.5 31.6 Krüger M et al. (2001) Sonic hedgehog is a survival factor for hypaxial muscles during mouse development. Development 128: 743-52 PubMed GONUTS page
  32. ↑ Garg V et al. (2001) Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol 235: 62-73 PubMed GONUTS page
  33. ↑ Nasr R et al. (2008) Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med 14: 1333-42 PubMed GONUTS page
  34. ↑ 34.0 34.1 Haraguchi R et al. (2001) Unique functions of Sonic hedgehog signaling during external genitalia development. Development 128: 4241-50 PubMed GONUTS page
  35. ↑ 35.0 35.1 35.2 35.3 35.4 35.5 35.6 Kraus P et al. (2001) Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Mech Dev 100: 45-58 PubMed GONUTS page
  36. ↑ 36.0 36.1 Tian H et al. (2004) Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development 131: 4021-33 PubMed GONUTS page
  37. ↑ 37.0 37.1 Kim JW & Lemke G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev 20: 2833-47 PubMed GONUTS page
  38. ↑ Stone DM et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-34 PubMed GONUTS page
  39. ↑ 39.0 39.1 39.2 Zhang Y et al. (1999) Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev Dyn 215: 45-53 PubMed GONUTS page
  40. ↑ 40.0 40.1 40.2 Pan Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol 26: 3365-77 PubMed GONUTS page
  41. ↑ Rice R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest 113: 1692-700 PubMed GONUTS page
  42. ↑ 42.0 42.1 Yamagishi C et al. (2006) Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res 59: 349-54 PubMed GONUTS page
  43. ↑ Izraeli S et al. (1999) The SIL gene is required for mouse embryonic axial development and left-right specification. Nature 399: 691-4 PubMed GONUTS page
  44. ↑ Buttitta L et al. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130: 6233-43 PubMed GONUTS page
  45. ↑ 45.0 45.1 45.2 Fu M et al. (2004) Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J Cell Biol 166: 673-84 PubMed GONUTS page
  46. ↑ Charron F et al. (2003) The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113: 11-23 PubMed GONUTS page
  47. ↑ 47.0 47.1 47.2 Dakubo GD et al. (2003) Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development 130: 2967-80 PubMed GONUTS page
  48. ↑ Balmer CW & LaMantia AS (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol 472: 292-307 PubMed GONUTS page
  49. ↑ Wijgerde M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16: 2849-64 PubMed GONUTS page
  50. ↑ 50.0 50.1 Mo R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol 159: 765-74 PubMed GONUTS page
  51. ↑ Rusiniak ME et al. (1996) Molecular markers near the mouse brachymorphic (bm) gene, which affects connective tissues and bleeding time. Mamm Genome 7: 98-102 PubMed GONUTS page
  52. ↑ 52.0 52.1 52.2 52.3 52.4 Berman DM et al. (2004) Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol 267: 387-98 PubMed GONUTS page
  53. ↑ Pan Y et al. (2009) Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol 326: 177-89 PubMed GONUTS page
  54. ↑ 54.0 54.1 54.2 Lewis PM et al. (2004) Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol 270: 393-410 PubMed GONUTS page
  55. ↑ 55.0 55.1 Corrales JD et al. (2004) Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131: 5581-90 PubMed GONUTS page
  56. ↑ 56.0 56.1 56.2 56.3 Wang Y et al. (2005) Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina. Development 132: 5103-13 PubMed GONUTS page
  57. ↑ 57.0 57.1 57.2 Grobe K et al. (2005) Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function. Development 132: 3777-86 PubMed GONUTS page
  58. ↑ 58.0 58.1 58.2 Lewis PM et al. (2001) Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105: 599-612 PubMed GONUTS page
  59. ↑ Jeong J & McMahon AP (2005) Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132: 143-54 PubMed GONUTS page
  60. ↑ Meng A et al. (1999) A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development 126: 1259-68 PubMed GONUTS page
  61. ↑ 61.0 61.1 Chiang C et al. (2001) Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol 236: 421-35 PubMed GONUTS page
  62. ↑ 62.0 62.1 Tucker ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J Neurosci 28: 9504-18 PubMed GONUTS page
  63. ↑ Pringle NP et al. (1996) Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev Biol 177: 30-42 PubMed GONUTS page
  64. ↑ Bai CB & Joyner AL (2001) Gli1 can rescue the in vivo function of Gli2. Development 128: 5161-72 PubMed GONUTS page
  65. ↑ Vokes SA et al. (2007) Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 134: 1977-89 PubMed GONUTS page
  66. ↑ 66.0 66.1 66.2 66.3 Allen BL et al. (2007) The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 21: 1244-57 PubMed GONUTS page
  67. ↑ Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page
  68. ↑ 68.0 68.1 68.2 Dahmane N & Ruiz i Altaba A (1999) Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126: 3089-100 PubMed GONUTS page
  69. ↑ Corbin JG et al. (2000) The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development 127: 5007-20 PubMed GONUTS page
  70. ↑ 70.0 70.1 Hashizume A & Hieda Y (2006) Hedgehog peptide promotes cell polarization and lumen formation in developing mouse submandibular gland. Biochem Biophys Res Commun 339: 996-1000 PubMed GONUTS page
  71. ↑ 71.0 71.1 71.2 Li Y et al. (2004) Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol 270: 214-31 PubMed GONUTS page
  72. ↑ 72.0 72.1 Reddy S et al. (2001) Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 107: 69-82 PubMed GONUTS page
  73. ↑ 73.0 73.1 Fan CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev Biol 191: 160-5 PubMed GONUTS page
  74. ↑ 74.0 74.1 74.2 Pepicelli CV et al. (1998) Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol 8: 1083-6 PubMed GONUTS page
  75. ↑ 75.0 75.1 Miller LA et al. (2004) Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231: 57-71 PubMed GONUTS page
  76. ↑ Harfe BD et al. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118: 517-28 PubMed GONUTS page
  77. ↑ 77.0 77.1 Lallemand Y et al. (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol 331: 189-98 PubMed GONUTS page
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