GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Sharpin
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sharpin ( synonyms: cpdm, SIPL1 ) | |
| Protein Name(s) | SHANK-associated RH domain interacting protein, | |
| External Links | ||
| MGI | MGI:1913331 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0007005 |
mitochondrion organization |
MGI:MGI:75289 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856699 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008544 |
epidermis development |
MGI:MGI:75289 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856699 |
P |
From MGI |
||
| GO:0010803 |
regulation of tumor necrosis factor-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010803 |
regulation of tumor necrosis factor-mediated signaling pathway |
MGI:MGI:4947438 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010803 |
regulation of tumor necrosis factor-mediated signaling pathway |
MGI:MGI:4947439 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112415 |
C |
From MGI |
||
| GO:0030262 |
apoptotic nuclear change |
MGI:MGI:75289 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856699 |
P |
From MGI |
||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112415 |
C |
From MGI |
||
| GO:0031424 |
keratinization |
MGI:MGI:75289 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856699 |
P |
From MGI |
||
| GO:0031593 |
polyubiquitin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112415 |
F |
From MGI |
||
| GO:0042802 |
identical protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112415 |
F |
From MGI |
||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:4947438 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:4947439 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:4947438 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:4947439 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112415 |
P |
From MGI |
||
| GO:0071797 |
LUBAC complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0097039 |
protein linear polyubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000348 |
regulation of CD40 signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gijbels MJ et al. (1995) Ultrastructure of epidermis of mice with chronic proliferative dermatitis. Ultrastruct Pathol 19: 107-11 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Tokunaga F et al. (2011) SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex. Nature 471: 633-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gerlach B et al. (2011) Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471: 591-6 PubMed GONUTS page
