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MGI:Shank3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Shank3 | |
| Protein Name(s) | SH3/ankyrin domain gene 3, | |
| External Links | ||
| MGI | MGI:1930016 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000165 |
MAPK cascade |
MGI:MGI:3513229 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97902 |
P |
From MGI |
||
| GO:0001838 |
embryonic epithelial tube formation |
MGI:MGI:3513229 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97902 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3513229 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3513229 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97902 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:3624607 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007416 |
synapse assembly |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:3624607 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
F |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
F |
From MGI |
||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0017124 |
SH3 domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
F |
From MGI |
||
| GO:0021773 |
striatal medium spiny neuron differentiation |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030160 |
GKAP/Homer scaffold activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
F |
From MGI |
||
| GO:0032232 |
negative regulation of actin filament bundle assembly |
MGI:MGI:3846509 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035176 |
social behavior |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035176 |
social behavior |
MGI:MGI:5285139 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035255 |
ionotropic glutamate receptor binding |
MGI:MGI:3624607 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0035255 |
ionotropic glutamate receptor binding |
MGI:MGI:3852309 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0035641 |
locomotory exploration behavior |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043621 |
protein self-association |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
F |
From MGI |
||
| GO:0044309 |
neuron spine |
MGI:MGI:3624607 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
C |
From MGI |
||
| GO:0045211 |
postsynaptic membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0628 |
C |
From MGI |
||
| GO:0045794 |
negative regulation of cell volume |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048170 |
positive regulation of long-term neuronal synaptic plasticity |
MGI:MGI:5285139 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048854 |
brain morphogenesis |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051259 |
protein oligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
P |
From MGI |
||
| GO:0051835 |
positive regulation of synapse structural plasticity |
MGI:MGI:5285139 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
MGI:MGI:5285139 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060076 |
excitatory synapse |
MGI:MGI:4948759 |
IC: Inferred by Curator |
GO:0051966 |
C |
From MGI |
||
| GO:0060170 |
cilium membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
C |
From MGI |
||
| GO:0060997 |
dendritic spine morphogenesis |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060997 |
dendritic spine morphogenesis |
MGI:MGI:5285139 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071625 |
vocalization behavior |
MGI:MGI:5285139 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0097107 |
postsynaptic density assembly |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0097110 |
scaffold protein binding |
MGI:MGI:3624607 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0097110 |
scaffold protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_067708 |
F |
From MGI |
||
| GO:2000463 |
positive regulation of excitatory postsynaptic membrane potential |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000463 |
positive regulation of excitatory postsynaptic membrane potential |
MGI:MGI:5285139 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000821 |
regulation of grooming behavior |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000822 |
regulation of behavioral fear response |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000969 |
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
MGI:MGI:4948759 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Schuetz G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol 167: 945-52 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Uchino S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J Neurochem 97: 1203-14 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Peça J et al. (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472: 437-42 PubMed GONUTS page
- ↑ Sawallisch C et al. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem 284: 9225-36 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Bozdagi O et al. (2010) Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism 1: 15 PubMed GONUTS page
- ↑ Uemura T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol Cell Neurosci 26: 330-41 PubMed GONUTS page
