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MGI:Sh2b2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sh2b2 ( synonyms: Aps ) | |
| Protein Name(s) | SH2B adaptor protein 2, | |
| External Links | ||
| MGI | MGI:1345171 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001725 |
stress fiber |
MGI:MGI:3590011 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001726 |
ruffle |
MGI:MGI:3590011 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001922 |
B-1 B cell homeostasis |
MGI:MGI:3033759 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680256 |
P |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005068 |
transmembrane receptor protein tyrosine kinase adaptor activity |
MGI:MGI:1334765 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005070 |
SH3/SH2 adaptor activity |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005070 |
SH3/SH2 adaptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1334765 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1859033 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q62120 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3590011 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005543 |
phospholipid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3687691 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005884 |
actin filament |
MGI:MGI:3033759 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3687691 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007399 |
nervous system development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_446121 |
P |
From MGI |
||
| GO:0008269 |
JAK pathway signal transduction adaptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008286 |
insulin receptor signaling pathway |
MGI:MGI:1334765 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009967 |
positive regulation of signal transduction |
MGI:MGI:1334765 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009967 |
positive regulation of signal transduction |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009967 |
positive regulation of signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019222 |
regulation of metabolic process |
MGI:MGI:2679365 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680256 |
P |
From MGI |
||
| GO:0030036 |
actin cytoskeleton organization |
MGI:MGI:3033759 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680256 |
P |
From MGI |
||
| GO:0030036 |
actin cytoskeleton organization |
MGI:MGI:3590011 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042593 |
glucose homeostasis |
MGI:MGI:2679365 |
ISA: Inferred from Sequence Alignment |
MGI:MGI:2680256 |
P |
From MGI |
||
| GO:0046325 |
negative regulation of glucose import |
MGI:MGI:2679365 |
ISA: Inferred from Sequence Alignment |
MGI:MGI:2680256 |
P |
From MGI |
||
| GO:0046425 |
regulation of JAK-STAT cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046578 |
regulation of Ras protein signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_446121 |
P |
From MGI |
||
| GO:0050776 |
regulation of immune response |
MGI:MGI:3033759 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680256 |
P |
From MGI |
||
| GO:0050851 |
antigen receptor-mediated signaling pathway |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050873 |
brown fat cell differentiation |
MGI:MGI:3801349 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Barrès R et al. (2005) The interaction between the adaptor protein APS and Enigma is involved in actin organisation. Exp Cell Res 308: 334-44 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Iseki M et al. (2004) Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains. Mol Cell Biol 24: 2243-50 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Moodie SA et al. (1999) Identification of the APS protein as a novel insulin receptor substrate. J Biol Chem 274: 11186-93 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page
- ↑ 5.0 5.1 Yokouchi M et al. (1999) APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. Oncogene 18: 759-67 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Minami A et al. (2003) Increased insulin sensitivity and hypoinsulinemia in APS knockout mice. Diabetes 52: 2657-65 PubMed GONUTS page
- ↑ Wu Y & Smas CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab 295: E205-15 PubMed GONUTS page
