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MGI:Sfn
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sfn ( synonyms: 14-3-3 sigma, Er, MME1, Ywhas ) | |
| Protein Name(s) | stratifin, | |
| External Links | ||
| MGI | MGI:1891831 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000079 |
regulation of cyclin-dependent protein kinase activity |
MGI:MGI:1890017 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001836 |
release of cytochrome c from mitochondria |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3625597 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3625597 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3625597 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3692825 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1859211 |
P |
From MGI |
||
| GO:0008630 |
DNA damage response, signal transduction resulting in induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030216 |
keratinocyte differentiation |
MGI:MGI:3608244 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861121 |
P |
From MGI |
||
| GO:0030307 |
positive regulation of cell growth |
MGI:MGI:3625597 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043588 |
skin development |
MGI:MGI:3608244 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861121 |
P |
From MGI |
||
| GO:0043588 |
skin development |
MGI:MGI:3692825 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1859211 |
P |
From MGI |
||
| GO:0043616 |
keratinocyte proliferation |
MGI:MGI:3692825 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1859211 |
P |
From MGI |
||
| GO:0046827 |
positive regulation of protein export from nucleus |
MGI:MGI:3768327 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051219 |
phosphoprotein binding |
MGI:MGI:3768327 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0051726 |
regulation of cell cycle |
MGI:MGI:1890017 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Laronga C et al. (2000) Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 275: 23106-12 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Kim S et al. (2006) A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441: 362-5 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Richardson RJ et al. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet 38: 1329-34 PubMed GONUTS page
- ↑ 4.0 4.1 Li Q et al. (2005) Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse. Proc Natl Acad Sci U S A 102: 15977-82 PubMed GONUTS page
- ↑ 5.0 5.1 Dillon RL et al. (2007) An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol 27: 8648-57 PubMed GONUTS page
