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MGI:Scn2a1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Scn2a1 ( synonyms: Nav1.2 ) | |
| Protein Name(s) | sodium channel, voltage-gated, type II, alpha 1, | |
| External Links | ||
| MGI | MGI:98248 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001518 |
voltage-gated sodium channel complex |
MGI:MGI:2179539 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0001518 |
voltage-gated sodium channel complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005216 |
ion channel activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0407 |
F |
From MGI |
||
| GO:0005244 |
voltage-gated ion channel activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0851 |
F |
From MGI |
||
| GO:0005248 |
voltage-gated sodium channel activity |
MGI:MGI:2179539 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005248 |
voltage-gated sodium channel activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005272 |
sodium channel activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0894 |
F |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:2179539 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3712711 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0006811 |
ion transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0406 |
P |
From MGI |
||
| GO:0006814 |
sodium ion transport |
MGI:MGI:2179539 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006814 |
sodium ion transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:2179539 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180186 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:2179539 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180186 |
P |
From MGI |
||
| GO:0014704 |
intercalated disc |
MGI:MGI:3625769 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019228 |
regulation of action potential in neuron |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030315 |
T-tubule |
MGI:MGI:3625769 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:3759695 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031402 |
sodium ion binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0033268 |
node of Ranvier |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0034765 |
regulation of ion transmembrane transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035725 |
sodium ion transmembrane transport |
MGI:MGI:2179539 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035725 |
sodium ion transmembrane transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043194 |
initial segment |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043522 |
leucine zipper domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Planells-Cases R et al. (2000) Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys J 78: 2878-91 PubMed GONUTS page
- ↑ Ogiwara I et al. (2007) Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci 27: 5903-14 PubMed GONUTS page
- ↑ 3.0 3.1 Haufe V et al. (2005) Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J Physiol 564: 683-96 PubMed GONUTS page
- ↑ Kalume F et al. (2007) Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. J Neurosci 27: 11065-74 PubMed GONUTS page
