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MGI:Scap
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Scap | |
| Protein Name(s) | SREBF chaperone, | |
| External Links | ||
| MGI | MGI:2135958 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
MGI:MGI:3767718 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2148743 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2388133 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0256 |
C |
From MGI |
||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:2388133 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001094436 |
C |
From MGI |
||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0333 |
C |
From MGI |
||
| GO:0006629 |
lipid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0443 |
P |
From MGI |
||
| GO:0006994 |
positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008202 |
steroid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0753 |
P |
From MGI |
||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:1934968 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0015485 |
cholesterol binding |
MGI:MGI:1934968 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0019217 |
regulation of fatty acid metabolic process |
MGI:MGI:1934968 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0968 |
C |
From MGI |
||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001094436 |
F |
From MGI |
||
| GO:0032868 |
response to insulin stimulus |
MGI:MGI:3770209 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2148743 |
P |
From MGI |
||
| GO:0042304 |
regulation of fatty acid biosynthetic process |
MGI:MGI:3770209 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2148743 |
P |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001094436 |
C |
From MGI |
||
| GO:0045540 |
regulation of cholesterol biosynthetic process |
MGI:MGI:3770209 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2148743 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Li J et al. (2007) Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia. Physiol Genomics 31: 273-80 PubMed GONUTS page
- ↑ 2.0 2.1 Yabe D et al. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A 99: 12753-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Matsuda M et al. (2001) SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev 15: 1206-16 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Kuriyama H et al. (2005) Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cell Metab 1: 41-51 PubMed GONUTS page
