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MGI:Ryk
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ryk ( synonyms: ERK-3, Vik ) | |
| Protein Name(s) | receptor-like tyrosine kinase, | |
| External Links | ||
| MGI | MGI:101766 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004888 |
transmembrane signaling receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005109 |
frizzled binding |
MGI:MGI:3510085 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2667521 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3510085 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:69585 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3822212 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3822212 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:70393 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007409 |
axonogenesis |
MGI:MGI:3510085 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98956 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:3625635 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007411 |
axon guidance |
MGI:MGI:4887339 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1328634 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:3822212 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3510085 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3625635 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98958 |
P |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0017147 |
Wnt-protein binding |
MGI:MGI:3510085 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0017147 |
Wnt-protein binding |
MGI:MGI:3625635 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0017147 |
Wnt-protein binding |
MGI:MGI:3822212 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0022038 |
corpus callosum development |
MGI:MGI:3625635 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030182 |
neuron differentiation |
MGI:MGI:3822212 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031175 |
neuron projection development |
MGI:MGI:3510085 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042813 |
Wnt-activated receptor activity |
MGI:MGI:3510085 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048705 |
skeletal system morphogenesis |
MGI:MGI:2667521 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2667542 |
P |
From MGI |
||
| GO:0048843 |
negative regulation of axon extension involved in axon guidance |
MGI:MGI:3625635 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98958 |
P |
From MGI |
||
| GO:0050919 |
negative chemotaxis |
MGI:MGI:3625635 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98958 |
P |
From MGI |
||
| GO:0071679 |
commissural neuron axon guidance |
MGI:MGI:3625635 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2667542 |
P |
From MGI |
||
|
NOT |
GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:2667521 |
IDA: Inferred from Direct Assay |
F |
From MGI |
||
|
NOT |
GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:67935 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Lu W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119: 97-108 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Halford MM et al. (2000) Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nat Genet 25: 414-8 PubMed GONUTS page
- ↑ Yee K et al. (1993) Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors. Blood 82: 1335-43 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Lyu J et al. (2008) Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell 15: 773-80 PubMed GONUTS page
- ↑ Simoneaux DK et al. (1995) The receptor tyrosine kinase-related gene (ryk) demonstrates lineage and stage-specific expression in hematopoietic cells. J Immunol 154: 1157-66 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Keeble TR et al. (2006) The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci 26: 5840-8 PubMed GONUTS page
- ↑ Liu Y et al. (2005) Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci 8: 1151-9 PubMed GONUTS page
- ↑ Serfas MS & Tyner AL (1998) Ryk is expressed in a differentiation-specific manner in epithelial tissues and is strongly induced in decidualizing uterine stroma. Oncogene 17: 3435-44 PubMed GONUTS page
- ↑ Hovens CM et al. (1992) RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc Natl Acad Sci U S A 89: 11818-22 PubMed GONUTS page
