GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Runx3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Runx3 ( synonyms: AML2, Cbfa3 ) | |
| Protein Name(s) | runt related transcription factor 3, | |
| External Links | ||
| MGI | MGI:102672 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3759198 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000790 |
nuclear chromatin |
MGI:MGI:3759198 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
MGI:MGI:3759198 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0000981 |
sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:3759198 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2673083 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4454353 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3056362 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR013524 |
P |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:2177980 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007411 |
axon guidance |
MGI:MGI:2387717 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179229 |
P |
From MGI |
||
| GO:0031069 |
hair follicle morphogenesis |
MGI:MGI:3583033 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183399 |
P |
From MGI |
||
| GO:0031175 |
neuron projection development |
MGI:MGI:2387717 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179229 |
P |
From MGI |
||
| GO:0032609 |
interferon-gamma production |
MGI:MGI:4454353 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045786 |
negative regulation of cell cycle |
MGI:MGI:2177980 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048469 |
cell maturation |
MGI:MGI:3039923 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99829 |
P |
From MGI |
||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
MGI:MGI:2177980 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Zheng L et al. (2007) Runx3 negatively regulates Osterix expression in dental pulp cells. Biochem J 405: 69-75 PubMed GONUTS page
- ↑ Zhang L et al. (2003) Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. J Biol Chem 278: 33097-104 PubMed GONUTS page
- ↑ 3.0 3.1 Yagi R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32: 507-17 PubMed GONUTS page
- ↑ Brenner O et al. (2004) Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A 101: 16016-21 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Li QL et al. (2002) Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109: 113-24 PubMed GONUTS page
- ↑ 6.0 6.1 Inoue K et al. (2002) Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci 5: 946-54 PubMed GONUTS page
- ↑ Raveh E et al. (2005) Runx3 is involved in hair shape determination. Dev Dyn 233: 1478-87 PubMed GONUTS page
- ↑ Yoshida CA et al. (2004) Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev 18: 952-63 PubMed GONUTS page
