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MGI:Rrm2b
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Rrm2b ( synonyms: p53R2 ) | |
| Protein Name(s) | ribonucleotide reductase M2 B (TP53 inducible), | |
| External Links | ||
| MGI | MGI:2155865 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001822 |
kidney development |
MGI:MGI:2670318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0003014 |
renal system process |
MGI:MGI:2670318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
MGI:MGI:2152627 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001124015 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3714223 |
IC: Inferred by Curator |
GO:0006264 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:3714223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
C |
From MGI |
||
| GO:0006260 |
DNA replication |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0235 |
P |
From MGI |
||
| GO:0006264 |
mitochondrial DNA replication |
MGI:MGI:3714223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:2670318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From MGI |
||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:2670318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0009186 |
deoxyribonucleoside diphosphate metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0009200 |
deoxyribonucleoside triphosphate metabolic process |
MGI:MGI:2670318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0009200 |
deoxyribonucleoside triphosphate metabolic process |
MGI:MGI:3714223 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0009263 |
deoxyribonucleotide biosynthetic process |
MGI:MGI:2152627 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:2670318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2672883 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046914 |
transition metal ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Kimura T et al. (2003) Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat Genet 34: 440-5 PubMed GONUTS page
- ↑ 2.0 2.1 Guittet O et al. (2001) Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J Biol Chem 276: 40647-51 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Bourdon A et al. (2007) Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet 39: 776-80 PubMed GONUTS page
