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MGI:Rrm2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Rrm2 ( synonyms: R2 ) | |
| Protein Name(s) | ribonucleotide reductase M2, | |
| External Links | ||
| MGI | MGI:98181 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
MGI:MGI:3695248 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
MGI:MGI:3846285 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2655004 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3695248 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001020911 |
C |
From MGI |
||
| GO:0005635 |
nuclear envelope |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001020911 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0006260 |
DNA replication |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0235 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001020911 |
P |
From MGI |
||
| GO:0009186 |
deoxyribonucleoside diphosphate metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0009262 |
deoxyribonucleotide metabolic process |
MGI:MGI:2655004 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009263 |
deoxyribonucleotide biosynthetic process |
MGI:MGI:3846285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046914 |
transition metal ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0051259 |
protein oligomerization |
MGI:MGI:3695232 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0051290 |
protein heterotetramerization |
MGI:MGI:3846285 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
|
contributes_to |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
MGI:MGI:3695232 |
IDA: Inferred from Direct Assay |
F |
From MGI |
||
|
contributes_to |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
MGI:MGI:58564 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
||
|
contributes_to |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
MGI:MGI:79384 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Narváez AJ et al. (2006) The involvement of Arg265 of mouse ribonucleotide reductase R2 protein in proton transfer and catalysis. J Biol Chem 281: 26022-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Zahedi Avval F & Holmgren A (2009) Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase. J Biol Chem 284: 8233-40 PubMed GONUTS page
- ↑ 3.0 3.1 Chabes AL et al. (2003) Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A 100: 3925-9 PubMed GONUTS page
- ↑ 4.0 4.1 Rofougaran R et al. (2006) Enzymatically active mammalian ribonucleotide reductase exists primarily as an alpha6beta2 octamer. J Biol Chem 281: 27705-11 PubMed GONUTS page
- ↑ Thelander M & Thelander L (1989) Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a new dominant marker gene. EMBO J 8: 2475-9 PubMed GONUTS page
- ↑ Fan H et al. (1996) A link between ferritin gene expression and ribonucleotide reductase R2 protein, as demonstrated by retroviral vector mediated stable expression of R2 cDNA. FEBS Lett 382: 145-8 PubMed GONUTS page
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