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MGI:Rps6

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Rps6 ( synonyms: S6R )
Protein Name(s) ribosomal protein S6,
External Links
MGI MGI:98159

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000028

ribosomal small subunit assembly

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62755

P

From MGI

GO:0000082

G1/S transition of mitotic cell cycle

MGI:MGI:1859684
PMID:10856218[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471
MGI:MGI:2176073

P

From MGI

GO:0001890

placenta development

MGI:MGI:3696931
PMID:17000767[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0002309

T cell proliferation involved in immune response

MGI:MGI:3610868
PMID:16357222[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:98834

P

From MGI

GO:0002309

T cell proliferation involved in immune response

MGI:MGI:3610868
PMID:16357222[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0003735

structural constituent of ribosome

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62755

F

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

C

From MGI

GO:0005730

nucleolus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2450792
PMID:12388085[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:A2A3R5

C

From MGI

GO:0005840

ribosome

MGI:MGI:3032819
PMID:14681305[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005844

polysome

MGI:MGI:3032819
PMID:14681305[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006364

rRNA processing

MGI:MGI:3610868
PMID:16357222[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0006364

rRNA processing

MGI:MGI:3696931
PMID:17000767[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0006364

rRNA processing

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

P

From MGI

GO:0006924

activation-induced cell death of T cells

MGI:MGI:3610868
PMID:16357222[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0007067

mitosis

MGI:MGI:3696931
PMID:17000767[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0007369

gastrulation

MGI:MGI:3696931
PMID:17000767[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:98834

P

From MGI

GO:0007369

gastrulation

MGI:MGI:3696931
PMID:17000767[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0015935

small ribosomal subunit

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

C

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

F

From MGI

GO:0022605

oogenesis stage

MGI:MGI:3696931
PMID:17000767[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0022627

cytosolic small ribosomal subunit

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62755

C

From MGI

GO:0022627

cytosolic small ribosomal subunit

MGI:MGI:4459044

PANTHER:PTHR11502

C

From MGI

GO:0022627

cytosolic small ribosomal subunit

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

C

From MGI

GO:0030529

ribonucleoprotein complex

MGI:MGI:3822232
PMID:18809582[6]

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

C

From MGI

GO:0031575

mitotic cell cycle G1/S transition checkpoint

MGI:MGI:3610868
PMID:16357222[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0031929

TOR signaling cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

P

From MGI

GO:0033077

T cell differentiation in thymus

MGI:MGI:3610868
PMID:16357222[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:98834

P

From MGI

GO:0033077

T cell differentiation in thymus

MGI:MGI:3610868
PMID:16357222[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0042274

ribosomal small subunit biogenesis

MGI:MGI:1859684
PMID:10856218[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471
MGI:MGI:2176073

P

From MGI

GO:0042274

ribosomal small subunit biogenesis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62753

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:3696931
PMID:17000767[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI

GO:0048471

perinuclear region of cytoplasm

MGI:MGI:3610880
PMID:16286931[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0048821

erythrocyte development

MGI:MGI:3696931
PMID:17000767[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2387471

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Volarevic S et al. (2000) Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science 288: 2045-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Panić L et al. (2006) Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26: 8880-91 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Sulic S et al. (2005) Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes Dev 19: 3070-82 PubMed GONUTS page
  4. Kimball SR et al. (2003) Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol 284: C273-84 PubMed GONUTS page
  5. 5.0 5.1 Niksic M et al. (2004) The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet 13: 463-71 PubMed GONUTS page
  6. Maggi LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol 28: 7050-65 PubMed GONUTS page
  7. Tavazoie SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8: 1727-34 PubMed GONUTS page
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