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MGI:Rnf2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Rnf2 ( synonyms: dinG, Ring1B ) | |
| Protein Name(s) | ring finger protein 2, | |
| External Links | ||
| MGI | MGI:1101759 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3629244 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000151 |
ubiquitin ligase complex |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000151 |
ubiquitin ligase complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0000278 |
mitotic cell cycle |
MGI:MGI:2652937 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2653961 |
P |
From MGI |
||
| GO:0001702 |
gastrulation with mouth forming second |
MGI:MGI:2652937 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2653961 |
P |
From MGI |
||
| GO:0001739 |
sex chromatin |
MGI:MGI:3513221 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:2389282 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3530206 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3629244 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1859418 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1927299 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2389282 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2679146 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3586402 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3612587 |
IPI: Inferred from Physical Interaction |
UniProtKB:O35730 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3715707 |
IPI: Inferred from Physical Interaction |
UniProtKB:O35730 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:5009373 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2679146 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009948 |
anterior/posterior axis specification |
MGI:MGI:2389282 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2447529 |
P |
From MGI |
||
| GO:0016574 |
histone ubiquitination |
MGI:MGI:3513221 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1101770 |
P |
From MGI |
||
| GO:0016574 |
histone ubiquitination |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016604 |
nuclear body |
MGI:MGI:2389282 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016874 |
ligase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0436 |
F |
From MGI |
||
| GO:0031519 |
PcG protein complex |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031519 |
PcG protein complex |
MGI:MGI:3628673 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031519 |
PcG protein complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035102 |
PRC1 complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035518 |
histone H2A monoubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0071339 |
MLL1 complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0071535 |
RING-like zinc finger domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Fujimura Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133: 2371-81 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Cao R et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 20: 845-54 PubMed GONUTS page
- ↑ 3.0 3.1 Voncken JW et al. (2003) Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A 100: 2468-73 PubMed GONUTS page
- ↑ 4.0 4.1 de Napoles M et al. (2004) Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell 7: 663-76 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Suzuki M et al. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129: 4171-83 PubMed GONUTS page
- ↑ Isono K et al. (2005) Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev 19: 536-41 PubMed GONUTS page
- ↑ Hemenway CS et al. (1998) The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene 16: 2541-7 PubMed GONUTS page
- ↑ García E et al. (1999) RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J 18: 3404-18 PubMed GONUTS page
- ↑ 9.0 9.1 Kaneko T et al. (2003) The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Gene 315: 183-92 PubMed GONUTS page
- ↑ Isono K et al. (2005) Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol Cell Biol 25: 6694-706 PubMed GONUTS page
- ↑ Sánchez C et al. (2007) Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 6: 820-34 PubMed GONUTS page
- ↑ Neira JL et al. (2009) The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA. Biochemistry 48: 1348-60 PubMed GONUTS page
- ↑ Lorente M et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev 123: 312-20 PubMed GONUTS page
