MGI:Ret

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000165	MAPK cascade	MGI:MGI:3513229 PMID:15569713^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1930016	P	From MGI
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001657	ureteric bud development	MGI:MGI:2385976 PMID:12195422^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P	From MGI
	GO:0001755	neural crest cell migration	MGI:MGI:3617928 PMID:15242795^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2449909	P	From MGI
	GO:0001838	embryonic epithelial tube formation	MGI:MGI:3513229 PMID:15569713^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001838	embryonic epithelial tube formation	MGI:MGI:3513229 PMID:15569713^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1930016	P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0829	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008266 InterPro:IPR020635	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2153440 PMID:11731455^[4]	TAS: Traceable Author Statement		F	From MGI
	GO:0005509	calcium ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR002126 InterPro:IPR015919	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1195875 PMID:9452475^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O35118	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3044859 PMID:15204970^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O35118	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3513229 PMID:15569713^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JJZ3	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441	F	From MGI
	GO:0005622	intracellular	MGI:MGI:3513229 PMID:15569713^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1930016	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63197	C	From MGI
	GO:0005768	endosome	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0967	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-1003	C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	C	From MGI
	GO:0007155	cell adhesion	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0130	P	From MGI
	GO:0007156	homophilic cell adhesion	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR002126	P	From MGI
	GO:0007158	neuron cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
	GO:0007158	neuron cell-cell adhesion	MGI:MGI:5306544 PMID:21357690^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:1203902 PMID:9576965^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:108417 MGI:MGI:1195462	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:3041894 PMID:11069590^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P	From MGI
	GO:0009653	anatomical structure morphogenesis	MGI:MGI:2153440 PMID:11731455^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0010008	endosome membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	C	From MGI
	GO:0010976	positive regulation of neuron projection development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
	GO:0014042	positive regulation of neuron maturation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63197	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR002126 InterPro:IPR015919	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0030155	regulation of cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
	GO:0033619	membrane protein proteolysis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
	GO:0033630	positive regulation of cell adhesion mediated by integrin	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
	GO:0035799	ureter maturation	MGI:MGI:4949948 PMID:21521737^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P	From MGI
	GO:0042551	neuron maturation	MGI:MGI:3052425 PMID:15233745^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63197	C	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3697544 PMID:17047028^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048265	response to pain	MGI:MGI:4441221 PMID:20237269^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048484	enteric nervous system development	MGI:MGI:1313212 PMID:9834195^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P	From MGI
	GO:0060384	innervation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63197	P	From MGI
	GO:0061146	Peyer's patch morphogenesis	MGI:MGI:3708043 PMID:17322904^[15]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071300	cellular response to retinoic acid	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
	GO:0072300	positive regulation of metanephric glomerulus development	MGI:MGI:3697544 PMID:17047028^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07949	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Schuetz G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol 167: 945-52 PubMed GONUTS page
↑ Batourina E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet 32: 109-15 PubMed GONUTS page
↑ Yan H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol 272: 118-33 PubMed GONUTS page
↑ ^4.0 ^4.1 Brophy PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128: 4747-56 PubMed GONUTS page
↑ Worby CA et al. (1998) Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem 273: 3502-8 PubMed GONUTS page
↑ Bolon B et al. (2004) The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol 32: 275-94 PubMed GONUTS page
↑ Cabrera JR et al. (2011) RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem 286: 14628-38 PubMed GONUTS page
↑ Baloh RH et al. (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci U S A 95: 5801-6 PubMed GONUTS page
↑ Rossi J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur J Neurosci 12: 3944-52 PubMed GONUTS page
↑ Chia I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development 138: 2089-97 PubMed GONUTS page
↑ Burau K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur J Neurosci 20: 353-62 PubMed GONUTS page
↑ ^12.0 ^12.1 Clarke JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum Mol Genet 15: 3420-8 PubMed GONUTS page
↑ Golden JP et al. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci 30: 3983-94 PubMed GONUTS page
↑ Natarajan D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126: 157-68 PubMed GONUTS page
↑ Veiga-Fernandes H et al. (2007) Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446: 547-51 PubMed GONUTS page

[PMID:15569713-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Schuetz G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol 167: 945-52 PubMed GONUTS page

[PMID:12195422-1] Batourina E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet 32: 109-15 PubMed GONUTS page

[PMID:15242795-2] Yan H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol 272: 118-33 PubMed GONUTS page

[PMID:11731455-3] 4.0 ^4.1 Brophy PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128: 4747-56 PubMed GONUTS page

[PMID:9452475-4] Worby CA et al. (1998) Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem 273: 3502-8 PubMed GONUTS page

[PMID:15204970-5] Bolon B et al. (2004) The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol 32: 275-94 PubMed GONUTS page

[PMID:21357690-6] Cabrera JR et al. (2011) RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem 286: 14628-38 PubMed GONUTS page

[PMID:9576965-7] Baloh RH et al. (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci U S A 95: 5801-6 PubMed GONUTS page

[PMID:11069590-8] Rossi J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur J Neurosci 12: 3944-52 PubMed GONUTS page

[PMID:21521737-9] Chia I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development 138: 2089-97 PubMed GONUTS page

[PMID:15233745-10] Burau K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur J Neurosci 20: 353-62 PubMed GONUTS page

[PMID:17047028-11] 12.0 ^12.1 Clarke JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum Mol Genet 15: 3420-8 PubMed GONUTS page

[PMID:20237269-12] Golden JP et al. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci 30: 3983-94 PubMed GONUTS page

[PMID:9834195-13] Natarajan D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126: 157-68 PubMed GONUTS page

[PMID:17322904-14] Veiga-Fernandes H et al. (2007) Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446: 547-51 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Ret ( synonyms: c-Ret, RET51, RET9 )
Protein Name(s)	ret proto-oncogene,
External Links
MGI	MGI:97902

MGI:Ret

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