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MGI:Rc3h1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Rc3h1 ( synonyms: roquin ) | |
| Protein Name(s) | RING CCCH (C3H) domains 1, | |
| External Links | ||
| MGI | MGI:2685397 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000932 |
cytoplasmic mRNA processing body |
MGI:MGI:4819285 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000956 |
nuclear-transcribed mRNA catabolic process |
MGI:MGI:4819285 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002634 |
regulation of germinal center formation |
MGI:MGI:3580753 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002634 |
regulation of germinal center formation |
MGI:MGI:3838060 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002635 |
negative regulation of germinal center formation |
MGI:MGI:5284769 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003723 |
RNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0694 |
F |
From MGI |
||
| GO:0003730 |
mRNA 3'-UTR binding |
MGI:MGI:4819285 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4819285 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3580753 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0010494 |
cytoplasmic stress granule |
MGI:MGI:3580753 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010494 |
cytoplasmic stress granule |
MGI:MGI:4819285 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010608 |
posttranscriptional regulation of gene expression |
MGI:MGI:4819285 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030889 |
negative regulation of B cell proliferation |
MGI:MGI:5284769 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033962 |
cytoplasmic mRNA processing body assembly |
MGI:MGI:4819285 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043488 |
regulation of mRNA stability |
MGI:MGI:5284769 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045623 |
negative regulation of T-helper cell differentiation |
MGI:MGI:3580753 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3581675 |
P |
From MGI |
||
| GO:0046007 |
negative regulation of activated T cell proliferation |
MGI:MGI:5284769 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050856 |
regulation of T cell receptor signaling pathway |
MGI:MGI:3580753 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Glasmacher E et al. (2010) Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol 11: 725-33 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Vinuesa CG et al. (2005) A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435: 452-8 PubMed GONUTS page
- ↑ Linterman MA et al. (2009) Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS. Immunity 30: 228-41 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Yu D et al. (2007) Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 450: 299-303 PubMed GONUTS page
