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MGI:Rbpj
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Rbpj ( synonyms: CBF1, Igkjrb, Igkrsbp, RBP-J kappa, RBPjk, Rbpsuh ) | |
| Protein Name(s) | recombination signal binding protein for immunoglobulin kappa J region, | |
| External Links | ||
| MGI | MGI:96522 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000978 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
MGI:MGI:3718932 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0000982 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:3808643 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001103 |
RNA polymerase II repressing transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001525 |
angiogenesis |
MGI:MGI:3056004 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0001837 |
epithelial to mesenchymal transition |
MGI:MGI:3027664 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0002193 |
MAML1-RBP-Jkappa- ICN1 complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0002437 |
inflammatory response to antigenic stimulus |
MGI:MGI:3718932 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2159049 |
ISA: Inferred from Sequence Alignment |
EMBL:L07872 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:87634 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3664138 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1859633 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:82631 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:87634 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q01705 |
F |
From MGI |
||
| GO:0005623 |
cell |
MGI:MGI:3718932 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:2159049 |
ISA: Inferred from Sequence Alignment |
EMBL:L07872 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3689772 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:86734 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:87634 |
IC: Inferred by Curator |
GO:0045892 |
C |
From MGI |
||
| GO:0005667 |
transcription factor complex |
MGI:MGI:3759692 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3574703 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97363 |
P |
From MGI |
||
| GO:0006959 |
humoral immune response |
MGI:MGI:3718932 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0007219 |
Notch signaling pathway |
MGI:MGI:3027664 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0007219 |
Notch signaling pathway |
MGI:MGI:3833041 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0007219 |
Notch signaling pathway |
MGI:MGI:3836883 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007221 |
positive regulation of transcription of Notch receptor target |
MGI:MGI:2663321 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97363 |
P |
From MGI |
||
| GO:0007221 |
positive regulation of transcription of Notch receptor target |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007507 |
heart development |
MGI:MGI:3027664 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:3710033 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3521553 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95516 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3689772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0009912 |
auditory receptor cell fate commitment |
MGI:MGI:3833041 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0009957 |
epidermal cell fate specification |
MGI:MGI:3689772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:86734 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0021983 |
pituitary gland development |
MGI:MGI:3664138 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0030097 |
hemopoiesis |
MGI:MGI:3574703 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0030182 |
neuron differentiation |
MGI:MGI:86734 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0030183 |
B cell differentiation |
MGI:MGI:2178898 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0030216 |
keratinocyte differentiation |
MGI:MGI:3689772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0035019 |
somatic stem cell maintenance |
MGI:MGI:5292802 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0042742 |
defense response to bacterium |
MGI:MGI:2178898 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3718933 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3759692 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045165 |
cell fate commitment |
MGI:MGI:3664138 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:1343651 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:3664138 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:87634 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:2159049 |
ISA: Inferred from Sequence Alignment |
EMBL:L07872 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:5315348 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0047485 |
protein N-terminus binding |
MGI:MGI:3709960 |
IPI: Inferred from Physical Interaction |
RefSeq:NP_001039272 |
F |
From MGI |
||
| GO:0048505 |
regulation of timing of cell differentiation |
MGI:MGI:3664138 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0048733 |
sebaceous gland development |
MGI:MGI:3689772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0048820 |
hair follicle maturation |
MGI:MGI:3689772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583755 |
P |
From MGI |
||
| GO:0072602 |
interleukin-4 secretion |
MGI:MGI:3718932 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857411 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Amsen D et al. (2007) Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27: 89-99 PubMed GONUTS page
- ↑ Niessen K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol 182: 315-25 PubMed GONUTS page
- ↑ Krebs LT et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev 18: 2469-73 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Timmerman LA et al. (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 18: 99-115 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Iso T et al. (2002) HERP1 is a cell type-specific primary target of Notch. J Biol Chem 277: 6598-607 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Minoguchi S et al. (1997) RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol 17: 2679-87 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Zhu X et al. (2006) Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev 20: 2739-53 PubMed GONUTS page
- ↑ Obata J et al. (2001) p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Genes Cells 6: 345-60 PubMed GONUTS page
- ↑ Tamura K et al. (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol 5: 1416-23 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Blanpain C et al. (2006) Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev 20: 3022-35 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 de la Pompa JL et al. (1997) Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124: 1139-48 PubMed GONUTS page
- ↑ 12.0 12.1 Masui T et al. (2007) Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev 21: 2629-43 PubMed GONUTS page
- ↑ 13.0 13.1 Robert-Moreno A et al. (2005) RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development 132: 1117-26 PubMed GONUTS page
- ↑ 14.0 14.1 Doetzlhofer A et al. (2009) Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell 16: 58-69 PubMed GONUTS page
- ↑ Wall DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 184: 101-12 PubMed GONUTS page
- ↑ Yun TJ & Bevan MJ (2003) Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J Immunol 170: 5834-41 PubMed GONUTS page
- ↑ Wang J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446: 882-7 PubMed GONUTS page
- ↑ Yoon K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci 24: 9497-506 PubMed GONUTS page
- ↑ 19.0 19.1 Tanigaki K et al. (2002) Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol 3: 443-50 PubMed GONUTS page
- ↑ Kim TH & Shivdasani RA (2011) Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med 208: 677-88 PubMed GONUTS page
- ↑ Fang TC et al. (2007) Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27: 100-10 PubMed GONUTS page
- ↑ Apelqvist A et al. (1999) Notch signalling controls pancreatic cell differentiation. Nature 400: 877-81 PubMed GONUTS page
- ↑ Oswald F et al. (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol 25: 10379-90 PubMed GONUTS page
- ↑ Ma X et al. (2007) Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation. Mol Cell Biol 27: 3056-64 PubMed GONUTS page
