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MGI:Rag1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Rag1 ( synonyms: Rag-1 ) | |
| Protein Name(s) | recombination activating gene 1, | |
| External Links | ||
| MGI | MGI:97848 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002331 |
pre-B cell allelic exclusion |
MGI:MGI:3848557 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003824 |
catalytic activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0511 |
F |
From MGI |
||
| GO:0004518 |
nuclease activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0540 |
F |
From MGI |
||
| GO:0004519 |
endonuclease activity |
MGI:MGI:4441118 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0004519 |
endonuclease activity |
MGI:MGI:4441148 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:3029666 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4441018 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4441135 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4441118 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:64624 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006310 |
DNA recombination |
MGI:MGI:2652309 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0511 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4442154 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0010390 |
histone monoubiquitination |
MGI:MGI:4441018 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016265 |
death |
MGI:MGI:1332944 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857241 |
P |
From MGI |
||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0016788 |
hydrolase activity, acting on ester bonds |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016874 |
ligase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0436 |
F |
From MGI |
||
| GO:0016881 |
acid-amino acid ligase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030183 |
B cell differentiation |
MGI:MGI:2178701 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030183 |
B cell differentiation |
MGI:MGI:50458 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033077 |
T cell differentiation in thymus |
MGI:MGI:50458 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033077 |
T cell differentiation in thymus |
MGI:MGI:893318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2448994 |
P |
From MGI |
||
| GO:0033151 |
V(D)J recombination |
MGI:MGI:4441018 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033151 |
V(D)J recombination |
MGI:MGI:4441148 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033151 |
V(D)J recombination |
MGI:MGI:50458 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033151 |
V(D)J recombination |
MGI:MGI:59028 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97849 |
P |
From MGI |
||
| GO:0033151 |
V(D)J recombination |
MGI:MGI:64624 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042393 |
histone binding |
MGI:MGI:4441018 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4441118 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4442154 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:3531056 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4441118 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4441148 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:4441148 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0051865 |
protein autoubiquitination |
MGI:MGI:3029666 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070244 |
negative regulation of thymocyte apoptotic process |
MGI:MGI:3531056 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0540 |
P |
From MGI |
||
| GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
MGI:MGI:4441118 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
MGI:MGI:4441148 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hewitt SL et al. (2009) RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol 10: 655-64 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Yin FF et al. (2009) Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol 16: 499-508 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Kim DR et al. (1999) Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev 13: 3070-80 PubMed GONUTS page
- ↑ 4.0 4.1 Jones JM & Gellert M (2003) Autoubiquitylation of the V(D)J recombinase protein RAG1. Proc Natl Acad Sci U S A 100: 15446-51 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Grazini U et al. (2010) The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining. Mol Cell 37: 282-93 PubMed GONUTS page
- ↑ Yurchenko V et al. (2003) The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev 17: 581-5 PubMed GONUTS page
- ↑ 7.0 7.1 Sadofsky MJ et al. (1993) Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucleic Acids Res 21: 5644-50 PubMed GONUTS page
- ↑ Ohinata Y et al. (2003) A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. FEBS Lett 537: 1-5 PubMed GONUTS page
- ↑ 9.0 9.1 Bellon SF et al. (1997) Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster. Nat Struct Biol 4: 586-91 PubMed GONUTS page
- ↑ Hotchkiss RS et al. (1999) Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 162: 4148-56 PubMed GONUTS page
- ↑ Miyamoto A et al. (2002) Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 416: 865-9 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Mombaerts P et al. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68: 869-77 PubMed GONUTS page
- ↑ Maraskovsky E et al. (1997) Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell 89: 1011-9 PubMed GONUTS page
- ↑ Oettinger MA et al. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248: 1517-23 PubMed GONUTS page
- ↑ 15.0 15.1 Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201: 603-14 PubMed GONUTS page
