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MGI:Rad51
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Rad51 ( synonyms: Rad51a, Reca ) | |
| Protein Name(s) | RAD51 homolog (S. cerevisiae), | |
| External Links | ||
| MGI | MGI:97890 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000166 |
nucleotide binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0000724 |
double-strand break repair via homologous recombination |
MGI:MGI:3511388 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000724 |
double-strand break repair via homologous recombination |
MGI:MGI:3525800 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000724 |
double-strand break repair via homologous recombination |
MGI:MGI:3615835 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:1858570 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:2183707 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:2652933 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:2671746 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:3707920 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000794 |
condensed nuclear chromosome |
MGI:MGI:3027988 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000794 |
condensed nuclear chromosome |
MGI:MGI:3794139 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000794 |
condensed nuclear chromosome |
MGI:MGI:4457793 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3687414 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0000800 |
lateral element |
MGI:MGI:3813746 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003684 |
damaged DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003697 |
single-stranded DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2152549 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2670547 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3525800 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3609918 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4868525 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:87113 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:3615835 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3687414 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001102674 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006200 |
ATP catabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006200 |
ATP catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006259 |
DNA metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006268 |
DNA unwinding involved in replication |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006281 |
DNA repair |
MGI:MGI:3687414 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006281 |
DNA repair |
MGI:MGI:4442153 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006310 |
DNA recombination |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0233 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:3687414 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007126 |
meiosis |
MGI:MGI:1858570 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007126 |
meiosis |
MGI:MGI:2183707 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007131 |
reciprocal meiotic recombination |
MGI:MGI:3687414 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008094 |
DNA-dependent ATPase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016605 |
PML body |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0017111 |
nucleoside-triphosphatase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043142 |
single-stranded DNA-dependent ATPase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0051106 |
positive regulation of DNA ligation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Stark JM et al. (2004) Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol 24: 9305-16 PubMed GONUTS page
- ↑ 2.0 2.1 Gudmundsdottir K et al. (2004) DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. EMBO Rep 5: 989-93 PubMed GONUTS page
- ↑ 3.0 3.1 Wesoly J et al. (2006) Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol 26: 976-89 PubMed GONUTS page
- ↑ 4.0 4.1 Kneitz B et al. (2000) MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev 14: 1085-97 PubMed GONUTS page
- ↑ 5.0 5.1 Lipkin SM et al. (2002) Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet 31: 385-90 PubMed GONUTS page
- ↑ Kwan KY et al. (2003) Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A 100: 2526-31 PubMed GONUTS page
- ↑ Wong JC et al. (2003) Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet 12: 2063-76 PubMed GONUTS page
- ↑ Cherry SM et al. (2007) The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol 17: 373-8 PubMed GONUTS page
- ↑ Libby BJ et al. (2003) Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice. Proc Natl Acad Sci U S A 100: 15706-11 PubMed GONUTS page
- ↑ Yang F et al. (2008) Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J Cell Biol 180: 673-9 PubMed GONUTS page
- ↑ Kumar R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev 24: 1266-80 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 Li MJ et al. (1996) Rad51 expression and localization in B cells carrying out class switch recombination. Proc Natl Acad Sci U S A 93: 10222-7 PubMed GONUTS page
- ↑ Soper SF et al. (2008) Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell 15: 285-97 PubMed GONUTS page
- ↑ Sarkisian CJ et al. (2001) Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals. J Biol Chem 276: 37640-8 PubMed GONUTS page
- ↑ Houghtaling S et al. (2003) Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev 17: 2021-35 PubMed GONUTS page
- ↑ Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res 11: 1758-65 PubMed GONUTS page
- ↑ Akamatsu Y & Jasin M (2010) Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. PLoS Genet 6: e1001160 PubMed GONUTS page
- ↑ Sharan SK et al. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386: 804-10 PubMed GONUTS page
- ↑ Cui X et al. (1999) The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. Mutat Res 434: 75-88 PubMed GONUTS page
