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MGI:Pycard
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pycard ( synonyms: Asc, TMS-1 ) | |
| Protein Name(s) | PYD and CARD domain containing, | |
| External Links | ||
| MGI | MGI:1931465 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002020 |
protease binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_758825 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3046391 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3836373 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:3046391 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:1929559 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:1929559 |
ISO: Inferred from Sequence Orthology |
RefSeq:NM_013258 |
P |
From MGI |
||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_758825 |
P |
From MGI |
||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:3697006 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3686870 |
P |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:3046391 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046932 |
P |
From MGI |
||
| GO:0016505 |
apoptotic protease activator activity |
MGI:MGI:1929559 |
ISO: Inferred from Sequence Orthology |
RefSeq:NM_013258 |
F |
From MGI |
||
| GO:0032090 |
Pyrin domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032611 |
interleukin-1 beta production |
MGI:MGI:3836373 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2686159 |
P |
From MGI |
||
| GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:3046391 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046932 |
P |
From MGI |
||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_758825 |
C |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_758825 |
C |
From MGI |
||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_758825 |
P |
From MGI |
||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:3046391 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046932 |
P |
From MGI |
||
| GO:0044325 |
ion channel binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_758825 |
F |
From MGI |
||
| GO:0044444 |
cytoplasmic part |
MGI:MGI:3836373 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0050718 |
positive regulation of interleukin-1 beta secretion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Mariathasan S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430: 213-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Bürckstümmer T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10: 266-72 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Masumoto J et al. (2001) Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Exp Cell Res 262: 128-33 PubMed GONUTS page
- ↑ Kanneganti TD et al. (2006) Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 281: 36560-8 PubMed GONUTS page
