GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Pxn
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pxn ( synonyms: Pax ) | |
| Protein Name(s) | paxillin, | |
| External Links | ||
| MGI | MGI:108295 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000187 |
activation of MAPK activity |
MGI:MGI:2680875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001012147 |
F |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:1858547 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:2157255 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:2178732 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:2446071 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:2680875 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:3577694 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:3624072 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:3821807 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001012147 |
C |
From MGI |
||
| GO:0005925 |
focal adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006928 |
cellular component movement |
MGI:MGI:2157255 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158458 |
P |
From MGI |
||
| GO:0007010 |
cytoskeleton organization |
MGI:MGI:2157255 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158458 |
P |
From MGI |
||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007229 |
integrin-mediated signaling pathway |
MGI:MGI:2157255 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158458 |
P |
From MGI |
||
| GO:0007229 |
integrin-mediated signaling pathway |
MGI:MGI:2178732 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0017166 |
vinculin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:3510095 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001012147 |
F |
From MGI |
||
| GO:0030027 |
lamellipodium |
MGI:MGI:2680875 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030027 |
lamellipodium |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030032 |
lamellipodium assembly |
MGI:MGI:2680875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030159 |
receptor signaling complex scaffold activity |
MGI:MGI:2157255 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0031252 |
cell leading edge |
MGI:MGI:3821807 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001012147 |
F |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048041 |
focal adhesion assembly |
MGI:MGI:2680875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048754 |
branching morphogenesis of a tube |
MGI:MGI:2680875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051435 |
BH4 domain binding |
MGI:MGI:3036971 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0060396 |
growth hormone receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ishibe S et al. (2003) Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol Cell 12: 1275-85 PubMed GONUTS page
- ↑ Lai KM & Pawson T (2000) The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev 14: 1132-45 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Hagel M et al. (2002) The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 22: 901-15 PubMed GONUTS page
- ↑ 4.0 4.1 Chay KO et al. (2002) Linkage of caspase-mediated degradation of paxillin to apoptosis in Ba/F3 murine pro-B lymphocytes. J Biol Chem 277: 14521-9 PubMed GONUTS page
- ↑ van der Flier A et al. (2002) Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol 156: 361-76 PubMed GONUTS page
- ↑ Pratt SJ et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol 168: 813-24 PubMed GONUTS page
- ↑ Acevedo K et al. (2006) LIM kinase 2 is widely expressed in all tissues. J Histochem Cytochem 54: 487-501 PubMed GONUTS page
- ↑ 8.0 8.1 Hirano M et al. (2008) EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol 182: 1217-30 PubMed GONUTS page
- ↑ Jacinto E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122-8 PubMed GONUTS page
- ↑ Sorenson CM (2004) Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. J Biol Chem 279: 11368-74 PubMed GONUTS page
