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MGI:Pth1r
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pth1r ( synonyms: PPR, PTH-related peptide receptor, PTH/PTHrP receptor, PTH1R, Pthr1 ) | |
| Protein Name(s) | parathyroid hormone 1 receptor, | |
| External Links | ||
| MGI | MGI:97801 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001501 |
skeletal system development |
MGI:MGI:2153596 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0001501 |
skeletal system development |
MGI:MGI:82059 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0001503 |
ossification |
MGI:MGI:3625556 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3628795 |
P |
From MGI |
||
| GO:0002062 |
chondrocyte differentiation |
MGI:MGI:3620436 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99829 |
P |
From MGI |
||
| GO:0002062 |
chondrocyte differentiation |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0002076 |
osteoblast development |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004888 |
transmembrane signaling receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004930 |
G-protein coupled receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0297 |
F |
From MGI |
||
| GO:0004930 |
G-protein coupled receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004991 |
parathyroid hormone receptor activity |
MGI:MGI:2153596 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004991 |
parathyroid hormone receptor activity |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
F |
From MGI |
||
| GO:0004991 |
parathyroid hormone receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004991 |
parathyroid hormone receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1352921 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3625556 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3628795 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007188 |
G-protein signaling, coupled to cAMP nucleotide second messenger |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0007200 |
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger |
MGI:MGI:3625556 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3628795 |
P |
From MGI |
||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3620436 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99829 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3625556 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3628795 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR017981 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0017046 |
peptide hormone binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030282 |
bone mineralization |
MGI:MGI:2153596 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0030282 |
bone mineralization |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0031526 |
brush border membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043621 |
protein self-association |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045453 |
bone resorption |
MGI:MGI:3624906 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154519 |
P |
From MGI |
||
| GO:0048469 |
cell maturation |
MGI:MGI:3625556 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3628795 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Kovacs CS et al. (2001) PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology 142: 4983-93 PubMed GONUTS page
- ↑ Lanske B et al. (1996) PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273: 663-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Guo J et al. (2002) The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell 3: 183-94 PubMed GONUTS page
- ↑ 4.0 4.1 Guo J et al. (2006) PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol 292: 116-28 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Lanske B et al. (1998) The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology 139: 5194-204 PubMed GONUTS page
- ↑ Lee K et al. (1996) Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology 137: 5109-18 PubMed GONUTS page
