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MGI:Ptgs2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ptgs2 ( synonyms: Cox-2, COX2, cyclooxygenase 2, cyclooxygenase-2, PGHS-2, Pghs2, PHS-2, prostaglandin G/H synthase, Tis10 ) | |
| Protein Name(s) | prostaglandin-endoperoxide synthase 2, | |
| External Links | ||
| MGI | MGI:97798 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001516 |
prostaglandin biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001516 |
prostaglandin biosynthetic process |
MGI:MGI:5315361 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001525 |
angiogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004601 |
peroxidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0575 |
F |
From MGI |
||
| GO:0004601 |
peroxidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004666 |
prostaglandin-endoperoxide synthase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004666 |
prostaglandin-endoperoxide synthase activity |
MGI:MGI:52337 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004666 |
prostaglandin-endoperoxide synthase activity |
MGI:MGI:5315361 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2181910 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0256 |
C |
From MGI |
||
| GO:0006633 |
fatty acid biosynthetic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0275 |
P |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007566 |
embryo implantation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007612 |
learning |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007613 |
memory |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008217 |
regulation of blood pressure |
MGI:MGI:2181847 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158457 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008289 |
lipid binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008610 |
lipid biosynthetic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0444 |
P |
From MGI |
||
| GO:0010575 |
positive regulation vascular endothelial growth factor production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010942 |
positive regulation of cell death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019233 |
sensory perception of pain |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019371 |
cyclooxygenase pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019371 |
cyclooxygenase pathway |
MGI:MGI:52337 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019371 |
cyclooxygenase pathway |
MGI:MGI:5315361 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0020037 |
heme binding |
MGI:MGI:5315361 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030216 |
keratinocyte differentiation |
MGI:MGI:2181114 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0030282 |
bone mineralization |
MGI:MGI:3797675 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030728 |
ovulation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031622 |
positive regulation of fever generation |
MGI:MGI:4413614 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031622 |
positive regulation of fever generation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031915 |
positive regulation of synaptic plasticity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032227 |
negative regulation of synaptic transmission, dopaminergic |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034097 |
response to cytokine stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035633 |
maintenance of blood-brain barrier |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:1855839 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88039 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:1889178 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88039 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:1932795 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88039 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:2157288 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88039 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:84229 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88039 |
P |
From MGI |
||
| GO:0042346 |
positive regulation of NF-kappaB import into nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042640 |
anagen |
MGI:MGI:3531621 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:5315361 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0043005 |
neuron projection |
MGI:MGI:2429331 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043005 |
neuron projection |
MGI:MGI:2429331 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045786 |
negative regulation of cell cycle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045907 |
positive regulation of vasoconstriction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045986 |
negative regulation of smooth muscle contraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045987 |
positive regulation of smooth muscle contraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046697 |
decidualization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050873 |
brown fat cell differentiation |
MGI:MGI:4454608 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051926 |
negative regulation of calcium ion transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071636 |
positive regulation of transforming growth factor beta production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090050 |
positive regulation of cell migration involved in sprouting angiogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090271 |
positive regulation of fibroblast growth factor production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090336 |
positive regulation of brown fat cell differentiation |
MGI:MGI:4454608 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090362 |
positive regulation of platelet-derived growth factor production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0005634 |
nucleus |
MGI:MGI:2181910 |
IDA: Inferred from Direct Assay |
C |
From MGI |
||
|
colocalizes_with |
GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Rowlinson SW et al. (2003) A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem 278: 45763-9 PubMed GONUTS page
- ↑ 2.0 2.1 Ryseck RP et al. (1992) Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity. Cell Growth Differ 3: 443-50 PubMed GONUTS page
- ↑ 3.0 3.1 Lazarus M et al. (2002) Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143: 2410-9 PubMed GONUTS page
- ↑ Qi Z et al. (2002) Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J Clin Invest 110: 61-9 PubMed GONUTS page
- ↑ Tiano HF et al. (2002) Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 62: 3395-401 PubMed GONUTS page
- ↑ Panupinthu N et al. (2008) P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J Cell Biol 181: 859-71 PubMed GONUTS page
- ↑ Hanada R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462: 505-9 PubMed GONUTS page
- ↑ Sasai H et al. (2000) Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis 21: 953-8 PubMed GONUTS page
- ↑ Chulada PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res 60: 4705-8 PubMed GONUTS page
- ↑ Oshima M et al. (2001) Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res 61: 1733-40 PubMed GONUTS page
- ↑ Seno H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res 62: 506-11 PubMed GONUTS page
- ↑ Oshima M et al. (1996) Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87: 803-9 PubMed GONUTS page
- ↑ Di-Poï N et al. (2005) Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol 25: 1696-712 PubMed GONUTS page
- ↑ 14.0 14.1 Ju WK & Neufeld AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol 452: 392-9 PubMed GONUTS page
- ↑ 15.0 15.1 Vegiopoulos A et al. (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328: 1158-61 PubMed GONUTS page
