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MGI:Ptger4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ptger4 ( synonyms: EP4, Ptgerep4 ) | |
| Protein Name(s) | prostaglandin E receptor 4 (subtype EP4), | |
| External Links | ||
| MGI | MGI:104311 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004871 |
signal transducer activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004930 |
G-protein coupled receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0297 |
F |
From MGI |
||
| GO:0004955 |
prostaglandin receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004957 |
prostaglandin E receptor activity |
MGI:MGI:1860392 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004957 |
prostaglandin E receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1860392 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
P |
From MGI |
||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0297 |
P |
From MGI |
||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000276 |
P |
From MGI |
||
| GO:0007188 |
G-protein signaling, coupled to cAMP nucleotide second messenger |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:1860392 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007254 |
JNK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000276 |
C |
From MGI |
||
| GO:0030278 |
regulation of ossification |
MGI:MGI:1860392 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2137851 |
P |
From MGI |
||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:3577831 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2137851 |
P |
From MGI |
||
| GO:0033624 |
negative regulation of integrin activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042093 |
T-helper cell differentiation |
MGI:MGI:4353445 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050710 |
negative regulation of cytokine secretion |
MGI:MGI:2151986 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050715 |
positive regulation of cytokine secretion |
MGI:MGI:4353445 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050729 |
positive regulation of inflammatory response |
MGI:MGI:4353445 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051492 |
regulation of stress fiber assembly |
MGI:MGI:5315359 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060348 |
bone development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070371 |
ERK1 and ERK2 cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000420 |
negative regulation of eosinophil extravasation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Miyaura C et al. (2000) Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice. J Biol Chem 275: 19819-23 PubMed GONUTS page
- ↑ Takayama K et al. (2005) Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med 11: 562-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Yao C et al. (2009) Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med 15: 633-40 PubMed GONUTS page
- ↑ Nataraj C et al. (2001) Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. J Clin Invest 108: 1229-35 PubMed GONUTS page
- ↑ Martineau LC et al. (2004) p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton. Am J Physiol Renal Physiol 286: F693-701 PubMed GONUTS page
