MGI:Prox1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4946187 PMID:21040746^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:3654815 PMID:16291864^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0001709	cell fate determination	MGI:MGI:2658694 PMID:12692551^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P	From MGI
	GO:0001938	positive regulation of endothelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0001945	lymph vessel development	MGI:MGI:3607876 PMID:16170315^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3609548 MGI:MGI:2450311	P	From MGI
	GO:0001946	lymphangiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0002089	lens morphogenesis in camera-type eye	MGI:MGI:1332720 PMID:10080188^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002194	hepatocyte cell migration	MGI:MGI:1860507 PMID:10888866^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3830437 PMID:19091769^[7]	NAS: Non-traceable Author Statement		F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:3830437 PMID:19091769^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003714	transcription corepressor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	F	From MGI
	GO:0005634	nucleus	MGI:MGI:3822424 PMID:19023449^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3830437 PMID:19091769^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3836138 PMID:11850194^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100671	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4946187 PMID:21040746^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3836138 PMID:11850194^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR007738	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2658694 PMID:12692551^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:2658694 PMID:12692551^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:1332720 PMID:10080188^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0010595	positive regulation of endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0016922	ligand-dependent nuclear receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	F	From MGI
	GO:0021542	dentate gyrus development	MGI:MGI:4849596 PMID:20808958^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0021707	cerebellar granule cell differentiation	MGI:MGI:4849596 PMID:20808958^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030240	skeletal muscle thin filament assembly	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4946187 PMID:21040746^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	F	From MGI
	GO:0045071	negative regulation of viral genome replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0045446	endothelial cell differentiation	MGI:MGI:2177970 PMID:11927535^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P	From MGI
	GO:0045737	positive regulation of cyclin-dependent protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0045750	positive regulation of S phase of mitotic cell cycle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0045787	positive regulation of cell cycle	MGI:MGI:1332720 PMID:10080188^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3654815 PMID:16291864^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048839	inner ear development	MGI:MGI:4437346 PMID:20186345^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P	From MGI
	GO:0048845	venous blood vessel morphogenesis	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050692	DBD domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	F	From MGI
	GO:0050693	LBD domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	F	From MGI
	GO:0055005	ventricular cardiac myofibril development	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0055009	atrial cardiac muscle tissue morphogenesis	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0055010	ventricular cardiac muscle tissue morphogenesis	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060214	endocardium formation	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060298	positive regulation of sarcomere organization	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060412	ventricular septum morphogenesis	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060414	aorta smooth muscle tissue morphogenesis	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060421	positive regulation of heart growth	MGI:MGI:3830437 PMID:19091769^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060836	lymphatic endothelial cell differentiation	MGI:MGI:3820329 PMID:19056883^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3609548 MGI:MGI:2182767	P	From MGI
	GO:0060836	lymphatic endothelial cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0060849	regulation of transcription involved in lymphatic endothelial cell fate commitment	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0070309	lens fiber cell morphogenesis	MGI:MGI:1332720 PMID:10080188^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070858	negative regulation of bile acid biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92786	P	From MGI
	GO:0072574	hepatocyte proliferation	MGI:MGI:1860507 PMID:10888866^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P	From MGI
	GO:0097150	neuronal stem cell maintenance	MGI:MGI:4849596 PMID:20808958^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000179	positive regulation of neural precursor cell proliferation	MGI:MGI:4849596 PMID:20808958^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000979	positive regulation of forebrain neuron differentiation	MGI:MGI:4849596 PMID:20808958^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2001052	positive regulation of G1/S transition checkpoint	MGI:MGI:4946187 PMID:21040746^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Baxter SA et al. (2011) Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein. Biochim Biophys Acta 1813: 201-12 PubMed GONUTS page
↑ ^2.0 ^2.1 Shin JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17: 576-84 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Dyer MA et al. (2003) Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet 34: 53-8 PubMed GONUTS page
↑ Harvey NL et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet 37: 1072-81 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Wigle JT et al. (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21: 318-22 PubMed GONUTS page
↑ ^6.0 ^6.1 Sosa-Pineda B et al. (2000) Hepatocyte migration during liver development requires Prox1. Nat Genet 25: 254-5 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 Risebro CA et al. (2009) Prox1 maintains muscle structure and growth in the developing heart. Development 136: 495-505 PubMed GONUTS page
↑ Chen X et al. (2008) PCNA interacts with Prox1 and represses its transcriptional activity. Mol Vis 14: 2076-86 PubMed GONUTS page
↑ ^9.0 ^9.1 Duncan MK et al. (2002) Prox1 is differentially localized during lens development. Mech Dev 112: 195-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Lavado A et al. (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol 8: PubMed GONUTS page
↑ Wigle JT et al. (2002) An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J 21: 1505-13 PubMed GONUTS page
↑ Fritzsch B et al. (2010) Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS One 5: e9377 PubMed GONUTS page
↑ Johnson NC et al. (2008) Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev 22: 3282-91 PubMed GONUTS page

[PMID:21040746-0] 1.0 ^1.1 ^1.2 ^1.3 Baxter SA et al. (2011) Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein. Biochim Biophys Acta 1813: 201-12 PubMed GONUTS page

[PMID:16291864-1] 2.0 ^2.1 Shin JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17: 576-84 PubMed GONUTS page

[PMID:12692551-2] 3.0 ^3.1 ^3.2 Dyer MA et al. (2003) Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet 34: 53-8 PubMed GONUTS page

[PMID:16170315-3] Harvey NL et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet 37: 1072-81 PubMed GONUTS page

[PMID:10080188-4] 5.0 ^5.1 ^5.2 ^5.3 Wigle JT et al. (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21: 318-22 PubMed GONUTS page

[PMID:10888866-5] 6.0 ^6.1 Sosa-Pineda B et al. (2000) Hepatocyte migration during liver development requires Prox1. Nat Genet 25: 254-5 PubMed GONUTS page

[PMID:19091769-6] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 Risebro CA et al. (2009) Prox1 maintains muscle structure and growth in the developing heart. Development 136: 495-505 PubMed GONUTS page

[PMID:19023449-7] Chen X et al. (2008) PCNA interacts with Prox1 and represses its transcriptional activity. Mol Vis 14: 2076-86 PubMed GONUTS page

[PMID:11850194-8] 9.0 ^9.1 Duncan MK et al. (2002) Prox1 is differentially localized during lens development. Mech Dev 112: 195-8 PubMed GONUTS page

[PMID:20808958-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Lavado A et al. (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol 8: PubMed GONUTS page

[PMID:11927535-10] Wigle JT et al. (2002) An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J 21: 1505-13 PubMed GONUTS page

[PMID:20186345-11] Fritzsch B et al. (2010) Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS One 5: e9377 PubMed GONUTS page

[PMID:19056883-12] Johnson NC et al. (2008) Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev 22: 3282-91 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Prox1
Protein Name(s)	prospero-related homeobox 1,
External Links
MGI	MGI:97772

MGI:Prox1

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