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MGI:Prop1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Prop1 ( synonyms: Prop-1, prophet of Pit-1, prophet of Pit1 ) | |
| Protein Name(s) | paired like homeodomain factor 1, | |
| External Links | ||
| MGI | MGI:109330 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3690195 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001568 |
blood vessel development |
MGI:MGI:3625414 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856842 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3690195 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3690195 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:3690195 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:3690195 |
IPI: Inferred from Physical Interaction |
MGI:MGI:88276 |
F |
From MGI |
||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:3690195 |
IPI: Inferred from Physical Interaction |
MGI:MGI:88276 |
F |
From MGI |
||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:2389279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856842 |
P |
From MGI |
||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:3512715 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3521736 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:2389279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856842 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3512715 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3521736 |
P |
From MGI |
||
| GO:0016477 |
cell migration |
MGI:MGI:3827091 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104853 |
P |
From MGI |
||
| GO:0021979 |
hypothalamus cell differentiation |
MGI:MGI:85929 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856842 |
P |
From MGI |
||
| GO:0021984 |
adenohypophysis development |
MGI:MGI:3827091 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3625414 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856842 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3690195 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3690195 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88276 |
P |
From MGI |
||
| GO:0048732 |
gland development |
MGI:MGI:3625414 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856842 |
P |
From MGI |
||
| GO:0048850 |
hypophysis morphogenesis |
MGI:MGI:3690195 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3690463 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3690195 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88276 |
P |
From MGI |
||
| GO:0060126 |
somatotropin secreting cell differentiation |
MGI:MGI:55682 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856842 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Olson LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125: 593-605 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Ward RD et al. (2006) Cell proliferation and vascularization in mouse models of pituitary hormone deficiency. Mol Endocrinol 20: 1378-90 PubMed GONUTS page
- ↑ 3.0 3.1 Raetzman LT et al. (2002) Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development 129: 4229-39 PubMed GONUTS page
- ↑ 4.0 4.1 Nasonkin IO et al. (2004) Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet 13: 2727-35 PubMed GONUTS page
- ↑ 5.0 5.1 Himes AD & Raetzman LT (2009) Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. Dev Biol 325: 151-61 PubMed GONUTS page
- ↑ Romero MI & Phelps CJ (1997) Identification of growth hormone-releasing hormone and somatostatin neurons projecting to the median eminence in normal and growth hormone-deficient Ames dwarf mice. Neuroendocrinology 65: 107-16 PubMed GONUTS page
- ↑ Cheng TC et al. (1983) Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice. Endocrinology 113: 1669-78 PubMed GONUTS page
