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MGI:Prnp
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Prnp ( synonyms: CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc ) | |
| Protein Name(s) | prion protein, | |
| External Links | ||
| MGI | MGI:97769 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001933 |
negative regulation of protein phosphorylation |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0005507 |
copper ion binding |
MGI:MGI:2652950 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005507 |
copper ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2153789 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:2175940 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:2175940 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4821089 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006139 |
nucleobase-containing compound metabolic process |
MGI:MGI:2386138 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006878 |
cellular copper ion homeostasis |
MGI:MGI:2175940 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:2652950 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007611 |
learning or memory |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008017 |
microtubule binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0015631 |
tubulin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0031225 |
anchored to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0336 |
C |
From MGI |
||
| GO:0032689 |
negative regulation of interferon-gamma production |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032700 |
negative regulation of interleukin-17 production |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032703 |
negative regulation of interleukin-2 production |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043008 |
ATP-dependent protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3579917 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:2182534 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:2674181 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0046007 |
negative regulation of activated T cell proliferation |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046686 |
response to cadmium ion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046688 |
response to copper ion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050860 |
negative regulation of T cell receptor signaling pathway |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051087 |
chaperone binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0070885 |
negative regulation of calcineurin-NFAT signaling cascade |
MGI:MGI:4943618 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Hu W et al. (2010) Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling. Brain 133: 375-88 PubMed GONUTS page
- ↑ 2.0 2.1 Rachidi W et al. (2003) Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery. J Biol Chem 278: 9064-72 PubMed GONUTS page
- ↑ Spielhaupter C & Schätzl HM (2001) PrPC directly interacts with proteins involved in signaling pathways. J Biol Chem 276: 44604-12 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Lorenz H et al. (2002) Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases. J Biol Chem 277: 8508-16 PubMed GONUTS page
- ↑ Pauly PC & Harris DA (1998) Copper stimulates endocytosis of the prion protein. J Biol Chem 273: 33107-10 PubMed GONUTS page
- ↑ Nandi PK et al. (2002) Unusual property of prion protein unfolding in neutral salt solution. Biochemistry 41: 11017-24 PubMed GONUTS page
- ↑ Li A & Harris DA (2005) Mammalian prion protein suppresses Bax-induced cell death in yeast. J Biol Chem 280: 17430-4 PubMed GONUTS page
- ↑ Shaked Y et al. (2002) The binding of prion proteins to serum components is affected by detergent extraction conditions. J Neurochem 82: 1-5 PubMed GONUTS page
- ↑ Rouvinski A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem Biophys Res Commun 308: 750-8 PubMed GONUTS page
