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MGI:Prf1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Prf1 ( synonyms: perforin, Pfn, Pfp, Prf-1 ) | |
| Protein Name(s) | perforin 1 (pore forming protein), | |
| External Links | ||
| MGI | MGI:97551 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002357 |
defense response to tumor cell |
MGI:MGI:66009 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002418 |
immune response to tumor cell |
MGI:MGI:66009 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:5285144 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005768 |
endosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0967 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0007623 |
circadian rhythm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:5285144 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016023 |
cytoplasmic membrane-bounded vesicle |
MGI:MGI:2179173 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019835 |
cytolysis |
MGI:MGI:3531039 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019835 |
cytolysis |
MGI:MGI:66009 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0022829 |
wide pore channel activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0022829 |
wide pore channel activity |
MGI:MGI:5285144 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044194 |
cytolytic granule |
MGI:MGI:66009 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:5285144 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051607 |
defense response to virus |
MGI:MGI:66009 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Kägi D et al. (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369: 31-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Law RH et al. (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 468: 447-51 PubMed GONUTS page
- ↑ Crider-Pirkle S et al. (2002) Cubilin, a binding partner for galectin-3 in the murine utero-placental complex. J Biol Chem 277: 15904-12 PubMed GONUTS page
- ↑ Bots M et al. (2005) SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. Blood 105: 1153-61 PubMed GONUTS page
