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MGI:Ppt1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ppt1 ( synonyms: CLN1, D4Ertd184e ) | |
| Protein Name(s) | palmitoyl-protein thioesterase 1, | |
| External Links | ||
| MGI | MGI:1298204 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002084 |
protein depalmitoylation |
MGI:MGI:2154013 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0002084 |
protein depalmitoylation |
MGI:MGI:3608104 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0002084 |
protein depalmitoylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:1276629 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:1276629 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:3608104 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
C |
From MGI |
||
| GO:0005764 |
lysosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006464 |
protein modification process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006907 |
pinocytosis |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007040 |
lysosome organization |
MGI:MGI:3612221 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0007040 |
lysosome organization |
MGI:MGI:3654230 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3527191 |
P |
From MGI |
||
| GO:0007042 |
lysosomal lumen acidification |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007269 |
neurotransmitter secretion |
MGI:MGI:3608104 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007420 |
brain development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007601 |
visual perception |
MGI:MGI:3526470 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3527191 |
P |
From MGI |
||
| GO:0007625 |
grooming behavior |
MGI:MGI:2154013 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0008306 |
associative learning |
MGI:MGI:3580037 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:2154013 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:3526470 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3527191 |
P |
From MGI |
||
| GO:0008474 |
palmitoyl-(protein) hydrolase activity |
MGI:MGI:2154013 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
F |
From MGI |
||
| GO:0008474 |
palmitoyl-(protein) hydrolase activity |
MGI:MGI:3608104 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
F |
From MGI |
||
| GO:0008474 |
palmitoyl-(protein) hydrolase activity |
MGI:MGI:3655641 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008474 |
palmitoyl-(protein) hydrolase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0015031 |
protein transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016042 |
lipid catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016290 |
palmitoyl-CoA hydrolase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:3655641 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:1351142 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031579 |
membrane raft organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032429 |
regulation of phospholipase A2 activity |
MGI:MGI:3711639 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:1351142 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044257 |
cellular protein catabolic process |
MGI:MGI:3612221 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0044265 |
cellular macromolecule catabolic process |
MGI:MGI:3656423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176390 |
P |
From MGI |
||
| GO:0045121 |
membrane raft |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048260 |
positive regulation of receptor-mediated endocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048549 |
positive regulation of pinocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051181 |
cofactor transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051186 |
cofactor metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gupta P et al. (2001) Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Proc Natl Acad Sci U S A 98: 13566-71 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Virmani T et al. (2005) Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice. Neurobiol Dis 20: 314-23 PubMed GONUTS page
- ↑ 3.0 3.1 Salonen T et al. (1998) Mouse palmitoyl protein thioesterase: gene structure and expression of cDNA. Genome Res 8: 724-30 PubMed GONUTS page
- ↑ 4.0 4.1 Zhang Z et al. (2006) Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL. Hum Mol Genet 15: 337-46 PubMed GONUTS page
- ↑ Ahtiainen L et al. (2006) Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing. Exp Cell Res 312: 1540-53 PubMed GONUTS page
- ↑ 6.0 6.1 Jalanko A et al. (2005) Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons. Neurobiol Dis 18: 226-41 PubMed GONUTS page
- ↑ Wendt KD et al. (2005) Behavioral assessment in mouse models of neuronal ceroid lipofuscinosis using a light-cued T-maze. Behav Brain Res 161: 175-82 PubMed GONUTS page
- ↑ 8.0 8.1 Ahtiainen L et al. (2003) Palmitoyl protein thioesterase 1 is targeted to the axons in neurons. J Comp Neurol 455: 368-77 PubMed GONUTS page
- ↑ 9.0 9.1 Isosomppi J et al. (1999) Developmental expression of palmitoyl protein thioesterase in normal mice. Brain Res Dev Brain Res 118: 1-11 PubMed GONUTS page
- ↑ Zhang Z et al. (2007) Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration. Hum Mol Genet 16: 837-47 PubMed GONUTS page
- ↑ Cho SK et al. (2005) Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease. Glycobiology 15: 637-48 PubMed GONUTS page
