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MGI:Ppp1r9b

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ppp1r9b ( synonyms: neurabin II, spinophilin, SPL, Spn )
Protein Name(s) protein phosphatase 1, regulatory subunit 9B,
External Links
MGI MGI:2387581

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001932

regulation of protein phosphorylation

MGI:MGI:3616148
PMID:15218143[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2389199

P

From MGI

GO:0003779

actin binding

MGI:MGI:2181311
PMID:10922077[2]

TAS: Traceable Author Statement

F

From MGI

GO:0005515

protein binding

MGI:MGI:2678845
PMID:14550532[3]

IPI: Inferred from Physical Interaction

UniProtKB:O88809

F

From MGI

GO:0005515

protein binding

MGI:MGI:3583726
PMID:15996550[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q7TN74
UniProtKB:Q60875

F

From MGI

GO:0005515

protein binding

MGI:MGI:4397775
PMID:17464283[5]

IPI: Inferred from Physical Interaction

UniProtKB:O08849

F

From MGI

GO:0005515

protein binding

MGI:MGI:4397775
PMID:17464283[5]

IPI: Inferred from Physical Interaction

UniProtKB:P41220

F

From MGI

GO:0005634

nucleus

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From MGI

GO:0005654

nucleoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

C

From MGI

GO:0005856

cytoskeleton

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

C

From MGI

GO:0007015

actin filament organization

MGI:MGI:3583726
PMID:15996550[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q60875
UniProtKB:Q7TN74

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007399

nervous system development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016358

dendrite development

MGI:MGI:2181311
PMID:10922077[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2389199

P

From MGI

GO:0016477

cell migration

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

P

From MGI

GO:0019722

calcium-mediated signaling

MGI:MGI:4397775
PMID:17464283[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2389199

P

From MGI

GO:0030027

lamellipodium

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

C

From MGI

GO:0030036

actin cytoskeleton organization

MGI:MGI:2181311
PMID:10922077[2]

TAS: Traceable Author Statement

P

From MGI

GO:0030054

cell junction

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

From MGI

GO:0030154

cell differentiation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

From MGI

GO:0030175

filopodium

MGI:MGI:3583726
PMID:15996550[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030175

filopodium

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

C

From MGI

GO:0030308

negative regulation of cell growth

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

P

From MGI

GO:0030864

cortical actin cytoskeleton

MGI:MGI:3583726
PMID:15996550[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0032587

ruffle membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

C

From MGI

GO:0042995

cell projection

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0966

C

From MGI

GO:0045202

synapse

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0770

C

From MGI

GO:0046847

filopodium assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q96SB3

P

From MGI

GO:0071315

cellular response to morphine

MGI:MGI:3834288
PMID:18439408[6]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:2000474

regulation of opioid receptor signaling pathway

MGI:MGI:3834288
PMID:18439408[6]

IMP: Inferred from Mutant Phenotype

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Wang Q et al. (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304: 1940-4 PubMed GONUTS page
  2. 2.0 2.1 2.2 Feng J et al. (2000) Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A 97: 9287-92 PubMed GONUTS page
  3. Tsukada M et al. (2003) Identification of neurabin II as a novel doublecortin interacting protein. Mech Dev 120: 1033-43 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Ryan XP et al. (2005) The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron 47: 85-100 PubMed GONUTS page
  5. 5.0 5.1 5.2 Wang X et al. (2007) Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. EMBO J 26: 2768-76 PubMed GONUTS page
  6. 6.0 6.1 Charlton JJ et al. (2008) Multiple actions of spinophilin regulate mu opioid receptor function. Neuron 58: 238-47 PubMed GONUTS page
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