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MGI:Ppp1ca

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ppp1ca ( synonyms: dism2, Ppp1c )
Protein Name(s) protein phosphatase 1, catalytic subunit, alpha isoform,
External Links
MGI MGI:103016

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000164

protein phosphatase type 1 complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0004721

phosphoprotein phosphatase activity

MGI:MGI:2679135
PMID:14580336[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004721

phosphoprotein phosphatase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

F

From MGI

GO:0004722

protein serine/threonine phosphatase activity

MGI:MGI:1327477
PMID:9882488[2]

TAS: Traceable Author Statement

F

From MGI

GO:0004722

protein serine/threonine phosphatase activity

MGI:MGI:2183839
PMID:12115603[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004722

protein serine/threonine phosphatase activity

MGI:MGI:3028820
PMID:14640981[4]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004722

protein serine/threonine phosphatase activity

MGI:MGI:70347
PMID:7857673[5]

TAS: Traceable Author Statement

F

From MGI

GO:0004722

protein serine/threonine phosphatase activity

MGI:MGI:73007
PMID:7736790[6]

ISS: Inferred from Sequence or Structural Similarity

F

From MGI

GO:0005515

protein binding

MGI:MGI:3709531
PMID:17274640[7]

IPI: Inferred from Physical Interaction

UniProtKB:P17918
UniProtKB:P41136
UniProtKB:Q9WTX5

F

From MGI

GO:0005515

protein binding

MGI:MGI:5000151
PMID:21471512[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q7TMB3

F

From MGI

GO:0005515

protein binding

MGI:MGI:5000151
PMID:21471512[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q9CW07

F

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62136

C

From MGI

GO:0005634

nucleus

MGI:MGI:5000151
PMID:21471512[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005654

nucleoplasm

MGI:MGI:1327477
PMID:9882488[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005654

nucleoplasm

MGI:MGI:3039057
PMID:15042703[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:1327477
PMID:9882488[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3039057
PMID:15042703[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62136

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:5000151
PMID:21471512[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005975

carbohydrate metabolic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0119

P

From MGI

GO:0005977

glycogen metabolic process

MGI:MGI:73007
PMID:7736790[6]

TAS: Traceable Author Statement

P

From MGI

GO:0005979

regulation of glycogen biosynthetic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

P

From MGI

GO:0005981

regulation of glycogen catabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

P

From MGI

GO:0006417

regulation of translation

MGI:MGI:73007
PMID:7736790[6]

TAS: Traceable Author Statement

P

From MGI

GO:0006470

protein dephosphorylation

MGI:MGI:1327477
PMID:9882488[2]

TAS: Traceable Author Statement

P

From MGI

GO:0006470

protein dephosphorylation

MGI:MGI:2679135
PMID:14580336[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006470

protein dephosphorylation

MGI:MGI:3028820
PMID:14640981[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006470

protein dephosphorylation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

P

From MGI

GO:0007049

cell cycle

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From MGI

GO:0007143

female meiosis

MGI:MGI:1327477
PMID:9882488[2]

TAS: Traceable Author Statement

P

From MGI

GO:0008152

metabolic process

MGI:MGI:73007
PMID:7736790[6]

TAS: Traceable Author Statement

P

From MGI

GO:0009987

cellular process

MGI:MGI:70347
PMID:7857673[5]

TAS: Traceable Author Statement

P

From MGI

GO:0016787

hydrolase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

From MGI

GO:0016787

hydrolase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR004843
InterPro:IPR006186

F

From MGI

GO:0030324

lung development

MGI:MGI:3039057
PMID:15042703[9]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0042587

glycogen granule

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0043005

neuron projection

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0043021

ribonucleoprotein complex binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

F

From MGI

GO:0043025

neuronal cell body

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0043197

dendritic spine

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0043204

perikaryon

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P62138

C

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0048754

branching morphogenesis of a tube

MGI:MGI:3039057
PMID:15042703[9]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051301

cell division

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

From MGI

GO:0070688

MLL5-L complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62136

C

From MGI

GO:0072357

PTW/PP1 phosphatase complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P62136

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Kissil JL et al. (2003) Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell 12: 841-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Smith GD et al. (1998) Characterization of protein phosphatases in mouse oocytes. Dev Biol 204: 537-49 PubMed GONUTS page
  3. Ayllón V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur J Immunol 32: 1847-55 PubMed GONUTS page
  4. 4.0 4.1 Llorian M et al. (2004) SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Biochem J 378: 229-38 PubMed GONUTS page
  5. 5.0 5.1 Saadat M et al. (1994) Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. Jpn J Genet 69: 697-700 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Saadat M et al. (1995) Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes. Cytogenet Cell Genet 70: 55-7 PubMed GONUTS page
  7. Flores-Delgado G et al. (2007) A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J Proteome Res 6: 1165-75 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Luo X et al. (2011) Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes 60: 1435-45 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Hormi-Carver KK et al. (2004) Protein phosphatase 1alpha is required for murine lung growth and morphogenesis. Dev Dyn 229: 791-801 PubMed GONUTS page
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