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MGI:Ppargc1a
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ppargc1a ( synonyms: Gm11133, Pgc-1alpha, Pgc-1alphaa, Pgc1, Pgco1, PPAR Gamma Coactivator-1 ) | |
| Protein Name(s) | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, | |
| External Links | ||
| MGI | MGI:1342774 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3529655 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:3689805 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112637 |
F |
From MGI |
||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003723 |
RNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0694 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3531058 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3579714 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3689757 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3770090 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3770355 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4365360 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4819323 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3771455 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112637 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112637 |
C |
From MGI |
||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0007005 |
mitochondrion organization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112637 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:3843109 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0010941 |
regulation of cell death |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014850 |
response to muscle activity |
MGI:MGI:4867337 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016922 |
ligand-dependent nuclear receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0022904 |
respiratory electron transport chain |
MGI:MGI:3032469 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030374 |
ligand-dependent nuclear receptor transcription coactivator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031490 |
chromatin DNA binding |
MGI:MGI:3771455 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0034599 |
cellular response to oxidative stress |
MGI:MGI:4462723 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:4462723 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3032469 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3529655 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112637 |
P |
From MGI |
||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3053497 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104661 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4819323 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104740 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4867337 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046321 |
positive regulation of fatty acid oxidation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112637 |
P |
From MGI |
||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4418597 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070997 |
neuron death |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Guan HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 19: 453-61 PubMed GONUTS page
- ↑ Napal L et al. (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J Mol Biol 354: 751-9 PubMed GONUTS page
- ↑ Rodgers JT et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-8 PubMed GONUTS page
- ↑ Nemoto S et al. (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 280: 16456-60 PubMed GONUTS page
- ↑ Cooper MP et al. (2006) Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev 20: 2996-3009 PubMed GONUTS page
- ↑ Finck BN et al. (2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab 4: 199-210 PubMed GONUTS page
- ↑ Seale P et al. (2007) Transcriptional control of brown fat determination by PRDM16. Cell Metab 6: 38-54 PubMed GONUTS page
- ↑ Kajimura S et al. (2008) Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 22: 1397-409 PubMed GONUTS page
- ↑ 9.0 9.1 Kim HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol 30: 3126-39 PubMed GONUTS page
- ↑ 10.0 10.1 Compe E et al. (2007) Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci 10: 1414-22 PubMed GONUTS page
- ↑ Pan D et al. (2009) Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137: 73-86 PubMed GONUTS page
- ↑ 12.0 12.1 Rasbach KA et al. (2010) PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A 107: 21866-71 PubMed GONUTS page
- ↑ 13.0 13.1 Fan M et al. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev 18: 278-89 PubMed GONUTS page
- ↑ 14.0 14.1 Volakakis N et al. (2010) NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc Natl Acad Sci U S A 107: 12317-22 PubMed GONUTS page
- ↑ Lau P et al. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem 279: 36828-40 PubMed GONUTS page
- ↑ Nedumaran B et al. (2009) DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J Biol Chem 284: 27511-23 PubMed GONUTS page
