MGI:Pou5f1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3612803 PMID:16325584^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:88361 MGI:MGI:88362	P	From MGI
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:4887340 PMID:15047715^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0001710	mesodermal cell fate commitment	MGI:MGI:1355046 PMID:10742100^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001711	endodermal cell fate commitment	MGI:MGI:1355046 PMID:10742100^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001712	ectodermal cell fate commitment	MGI:MGI:1355046 PMID:10742100^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001714	endodermal cell fate specification	MGI:MGI:4887279 PMID:21245162^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0001829	trophectodermal cell differentiation	MGI:MGI:3612803 PMID:16325584^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1201683	P	From MGI
	GO:0003130	BMP signaling pathway involved in heart induction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2654980 PMID:12665572^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3589724 PMID:15863505^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:98363 MGI:MGI:98364	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:58746 PMID:1967980^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3582026 PMID:15988017^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3804326 PMID:18467660^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2654980 PMID:12665572^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001009178	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:58746 PMID:1967980^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:59016 PMID:2357966^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:59024 PMID:1972777^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003714	transcription corepressor activity	MGI:MGI:3612803 PMID:16325584^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:3773761 PMID:18191611^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P52480	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3777522 PMID:15917470^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q61545	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3813404 PMID:18662995^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q61539	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4399014 PMID:17541407^[15]	IPI: Inferred from Physical Interaction	UniProtKB:P87377	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4399017 PMID:17093407^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q80Z64	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4457231 PMID:19740739^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q3URR7	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4943831 PMID:20362542^[18]	IPI: Inferred from Physical Interaction	UniProtKB:P11103	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4946164 PMID:21076177^[19]	IPI: Inferred from Physical Interaction	UniProtKB:P63028 UniProtKB:Q5BL09	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5285127 PMID:21477851^[20]	IPI: Inferred from Physical Interaction	UniProtKB:P61965	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5315322 PMID:22036565^[21]	IPI: Inferred from Physical Interaction	UniProtKB:Q8BUN5	F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4367296 PMID:19796622^[22]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:1201721 PMID:9507072^[23]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:2654980 PMID:12665572^[5]	IC: Inferred by Curator	GO:0003700	C	From MGI
	GO:0005634	nucleus	MGI:MGI:2656389 PMID:12641567^[24]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:2678871 PMID:14502573^[25]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3044310 PMID:15183310^[26]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3512701 PMID:15525667^[27]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3583030 PMID:15977177^[28]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3612803 PMID:16325584^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3623851 PMID:16611995^[29]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3695521 PMID:17138661^[30]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3761040 PMID:17882221^[31]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3776892 PMID:7969117^[32]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3783966 PMID:18096721^[33]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3797149 PMID:18423437^[34]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3799386 PMID:18425773^[35]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3813404 PMID:18662995^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001009178	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4422111 PMID:20123909^[36]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4440771 PMID:20336070^[37]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4946964 PMID:21258368^[38]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:69449 PMID:7958450^[39]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005654	nucleoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	C	From MGI
	GO:0005654	nucleoplasm	MGI:MGI:4946164 PMID:21076177^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:3718872 PMID:17507372^[40]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:3776892 PMID:7969117^[32]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:69449 PMID:7958450^[39]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2654980 PMID:12665572^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001009178	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4887340 PMID:15047715^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:58746 PMID:1967980^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4399014 PMID:17541407^[15]	IPI: Inferred from Physical Interaction	UniProtKB:P70062	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4887542 PMID:19816951^[41]	IPI: Inferred from Physical Interaction	UniProtKB:Q60793	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4946164 PMID:21076177^[19]	IPI: Inferred from Physical Interaction	UniProtKB:P48432	F	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0017053	transcriptional repressor complex	MGI:MGI:3612803 PMID:16325584^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0019827	stem cell maintenance	MGI:MGI:1314760 PMID:9814708^[42]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933381	P	From MGI
	GO:0019827	stem cell maintenance	MGI:MGI:2678871 PMID:14502573^[25]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0019827	stem cell maintenance	MGI:MGI:3654397 PMID:16767105^[43]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030718	germ-line stem cell maintenance	MGI:MGI:3525816 PMID:15486564^[44]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3578312 MGI:MGI:2177588	P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	F	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4887340 PMID:15047715^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9DBH0	F	From MGI
	GO:0032526	response to retinoic acid	MGI:MGI:3795829 PMID:18400104^[45]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0035019	somatic stem cell maintenance	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0035198	miRNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	F	From MGI
	GO:0035413	positive regulation of catenin import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0042221	response to chemical stimulus	MGI:MGI:3795829 PMID:18400104^[45]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042789	mRNA transcription from RNA polymerase II promoter	MGI:MGI:4887340 PMID:15047715^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:1270966 PMID:9649510^[46]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:3621412 PMID:16518401^[47]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:3776892 PMID:7969117^[32]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:3795829 PMID:18400104^[45]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4367296 PMID:19796622^[22]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001009178	F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4887279 PMID:21245162^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:68656 PMID:7945330^[48]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:74622 PMID:1690859^[49]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:84539 PMID:8960364^[50]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4399014 PMID:17541407^[15]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	F	From MGI
	GO:0045165	cell fate commitment	MGI:MGI:1314760 PMID:9814708^[42]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933381	P	From MGI
	GO:0045596	negative regulation of cell differentiation	MGI:MGI:3612803 PMID:16325584^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1201683	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:58746 PMID:1967980^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:58746 PMID:1967980^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1270966 PMID:9649510^[46]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1270966 PMID:9649510^[46]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3582026 PMID:15988017^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3589724 PMID:15863505^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:98363 MGI:MGI:98364	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3694370 PMID:17097055^[51]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3718872 PMID:17507372^[40]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4887279 PMID:21245162^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:59024 PMID:1972777^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:77200 PMID:7590241^[52]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P	From MGI
	GO:0045955	negative regulation of calcium ion-dependent exocytosis	MGI:MGI:59016 PMID:2357966^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048863	stem cell differentiation	MGI:MGI:4422111 PMID:20123909^[36]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060391	positive regulation of SMAD protein import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0060795	cell fate commitment involved in formation of primary germ layers	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0060913	cardiac cell fate determination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0060965	negative regulation of gene silencing by miRNA	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0090081	regulation of heart induction by regulation of canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
	GO:0090308	regulation of methylation-dependent chromatin silencing	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q01860	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Niwa H et al. (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123: 917-29 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Xu HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 279: 23495-503 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Niwa H et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: 372-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Teo AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev 25: 238-50 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Tokuzawa Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol 23: 2699-708 PubMed GONUTS page
↑ ^6.0 ^6.1 Maruyama M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem 280: 24371-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Okamoto K et al. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60: 461-72 PubMed GONUTS page
↑ ^8.0 ^8.1 Chew JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25: 6031-46 PubMed GONUTS page
↑ Tam WL et al. (2008) T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells 26: 2019-31 PubMed GONUTS page
↑ ^10.0 ^10.1 Schöler HR et al. (1990) Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J 9: 2185-95 PubMed GONUTS page
↑ ^11.0 ^11.1 Rosner MH et al. (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345: 686-92 PubMed GONUTS page
↑ Lee J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol 40: 1043-54 PubMed GONUTS page
↑ Lee J et al. (2005) Stimulation of Oct-4 activity by Ewing's sarcoma protein. Stem Cells 23: 738-51 PubMed GONUTS page
↑ ^14.0 ^14.1 van den Berg DL et al. (2008) Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol 28: 5986-95 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Cao Y et al. (2007) POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J 26: 2942-54 PubMed GONUTS page
↑ Wang J et al. (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444: 364-8 PubMed GONUTS page
↑ Yu HB et al. (2009) Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem 284: 31327-35 PubMed GONUTS page
↑ Pardo M et al. (2010) An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 6: 382-95 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Johansson H & Simonsson S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2: 815-22 PubMed GONUTS page
↑ Ang YS et al. (2011) Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell 145: 183-97 PubMed GONUTS page
↑ Mullen AC et al. (2011) Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell 147: 565-76 PubMed GONUTS page
↑ ^22.0 ^22.1 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
↑ Pesce M et al. (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev 71: 89-98 PubMed GONUTS page
↑ Durcova-Hills G et al. (2003) Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro. Differentiation 71: 135-41 PubMed GONUTS page
↑ ^25.0 ^25.1 Velkey JM & O'Shea KS (2003) Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. Genesis 37: 18-24 PubMed GONUTS page
↑ Liu L et al. (2004) Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos. Gene Expr Patterns 4: 433-41 PubMed GONUTS page
↑ Kemler R et al. (2004) Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131: 5817-24 PubMed GONUTS page
↑ Barrow KM et al. (2005) Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev Dyn 233: 1535-45 PubMed GONUTS page
↑ Cormier S et al. (2006) The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Mol Cell Biol 26: 3541-9 PubMed GONUTS page
↑ Kan NG et al. (2007) Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134: 31-41 PubMed GONUTS page
↑ Seandel M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449: 346-50 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 Dailey L et al. (1994) Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol 14: 7758-69 PubMed GONUTS page
↑ Kuntz S et al. (2008) Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. Stem Cells 26: 734-44 PubMed GONUTS page
↑ Wang H et al. (2008) Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol 318: 112-25 PubMed GONUTS page
↑ Strizzi L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol 216: 824-34 PubMed GONUTS page
↑ ^36.0 ^36.1 Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: 312-26 PubMed GONUTS page
↑ Zalzman M et al. (2010) Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 464: 858-63 PubMed GONUTS page
↑ Plachta N et al. (2011) Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat Cell Biol 13: 117-23 PubMed GONUTS page
↑ ^39.0 ^39.1 Palmieri SL et al. (1994) Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166: 259-67 PubMed GONUTS page
↑ ^40.0 ^40.1 Li J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J Biol Chem 282: 19481-92 PubMed GONUTS page
↑ Wei Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27: 2969-78 PubMed GONUTS page
↑ ^42.0 ^42.1 Nichols J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: 379-91 PubMed GONUTS page
↑ Ivanova N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442: 533-8 PubMed GONUTS page
↑ Kehler J et al. (2004) Oct4 is required for primordial germ cell survival. EMBO Rep 5: 1078-83 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 Kunarso G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9: 155 PubMed GONUTS page
↑ ^46.0 ^46.1 ^46.2 Botquin V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev 12: 2073-90 PubMed GONUTS page
↑ Loh YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38: 431-40 PubMed GONUTS page
↑ Rosfjord E & Rizzino A (1994) The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Biochem Biophys Res Commun 203: 1795-802 PubMed GONUTS page
↑ Schöler HR et al. (1990) New type of POU domain in germ line-specific protein Oct-4. Nature 344: 435-9 PubMed GONUTS page
↑ Wang L & Schultz GA (1996) Expression of Oct-4 during differentiation of murine F9 cells. Biochem Cell Biol 74: 579-84 PubMed GONUTS page
↑ Tsuruzoe S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun 351: 920-6 PubMed GONUTS page
↑ Yuan H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9: 2635-45 PubMed GONUTS page

[PMID:16325584-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Niwa H et al. (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123: 917-29 PubMed GONUTS page

[PMID:15047715-1] 2.0 ^2.1 ^2.2 ^2.3 Xu HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 279: 23495-503 PubMed GONUTS page

[PMID:10742100-2] 3.0 ^3.1 ^3.2 Niwa H et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: 372-6 PubMed GONUTS page

[PMID:21245162-3] 4.0 ^4.1 ^4.2 Teo AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev 25: 238-50 PubMed GONUTS page

[PMID:12665572-4] 5.0 ^5.1 ^5.2 ^5.3 Tokuzawa Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol 23: 2699-708 PubMed GONUTS page

[PMID:15863505-5] 6.0 ^6.1 Maruyama M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem 280: 24371-9 PubMed GONUTS page

[PMID:1967980-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Okamoto K et al. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60: 461-72 PubMed GONUTS page

[PMID:15988017-7] 8.0 ^8.1 Chew JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25: 6031-46 PubMed GONUTS page

[PMID:18467660-8] Tam WL et al. (2008) T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells 26: 2019-31 PubMed GONUTS page

[PMID:2357966-9] 10.0 ^10.1 Schöler HR et al. (1990) Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J 9: 2185-95 PubMed GONUTS page

[PMID:1972777-10] 11.0 ^11.1 Rosner MH et al. (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345: 686-92 PubMed GONUTS page

[PMID:18191611-11] Lee J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol 40: 1043-54 PubMed GONUTS page

[PMID:15917470-12] Lee J et al. (2005) Stimulation of Oct-4 activity by Ewing's sarcoma protein. Stem Cells 23: 738-51 PubMed GONUTS page

[PMID:18662995-13] 14.0 ^14.1 van den Berg DL et al. (2008) Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol 28: 5986-95 PubMed GONUTS page

[PMID:17541407-14] 15.0 ^15.1 ^15.2 Cao Y et al. (2007) POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J 26: 2942-54 PubMed GONUTS page

[PMID:17093407-15] Wang J et al. (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444: 364-8 PubMed GONUTS page

[PMID:19740739-16] Yu HB et al. (2009) Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem 284: 31327-35 PubMed GONUTS page

[PMID:20362542-17] Pardo M et al. (2010) An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 6: 382-95 PubMed GONUTS page

[PMID:21076177-18] 19.0 ^19.1 ^19.2 Johansson H & Simonsson S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2: 815-22 PubMed GONUTS page

[PMID:21477851-19] Ang YS et al. (2011) Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell 145: 183-97 PubMed GONUTS page

[PMID:22036565-20] Mullen AC et al. (2011) Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell 147: 565-76 PubMed GONUTS page

[PMID:19796622-21] 22.0 ^22.1 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page

[PMID:9507072-22] Pesce M et al. (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev 71: 89-98 PubMed GONUTS page

[PMID:12641567-23] Durcova-Hills G et al. (2003) Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro. Differentiation 71: 135-41 PubMed GONUTS page

[PMID:14502573-24] 25.0 ^25.1 Velkey JM & O'Shea KS (2003) Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. Genesis 37: 18-24 PubMed GONUTS page

[PMID:15183310-25] Liu L et al. (2004) Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos. Gene Expr Patterns 4: 433-41 PubMed GONUTS page

[PMID:15525667-26] Kemler R et al. (2004) Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131: 5817-24 PubMed GONUTS page

[PMID:15977177-27] Barrow KM et al. (2005) Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev Dyn 233: 1535-45 PubMed GONUTS page

[PMID:16611995-28] Cormier S et al. (2006) The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Mol Cell Biol 26: 3541-9 PubMed GONUTS page

[PMID:17138661-29] Kan NG et al. (2007) Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134: 31-41 PubMed GONUTS page

[PMID:17882221-30] Seandel M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449: 346-50 PubMed GONUTS page

[PMID:7969117-31] 32.0 ^32.1 ^32.2 Dailey L et al. (1994) Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol 14: 7758-69 PubMed GONUTS page

[PMID:18096721-32] Kuntz S et al. (2008) Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. Stem Cells 26: 734-44 PubMed GONUTS page

[PMID:18423437-33] Wang H et al. (2008) Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol 318: 112-25 PubMed GONUTS page

[PMID:18425773-34] Strizzi L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol 216: 824-34 PubMed GONUTS page

[PMID:20123909-35] 36.0 ^36.1 Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: 312-26 PubMed GONUTS page

[PMID:20336070-36] Zalzman M et al. (2010) Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 464: 858-63 PubMed GONUTS page

[PMID:21258368-37] Plachta N et al. (2011) Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat Cell Biol 13: 117-23 PubMed GONUTS page

[PMID:7958450-38] 39.0 ^39.1 Palmieri SL et al. (1994) Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166: 259-67 PubMed GONUTS page

[PMID:17507372-39] 40.0 ^40.1 Li J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J Biol Chem 282: 19481-92 PubMed GONUTS page

[PMID:19816951-40] Wei Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27: 2969-78 PubMed GONUTS page

[PMID:9814708-41] 42.0 ^42.1 Nichols J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: 379-91 PubMed GONUTS page

[PMID:16767105-42] Ivanova N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442: 533-8 PubMed GONUTS page

[PMID:15486564-43] Kehler J et al. (2004) Oct4 is required for primordial germ cell survival. EMBO Rep 5: 1078-83 PubMed GONUTS page

[PMID:18400104-44] 45.0 ^45.1 ^45.2 Kunarso G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9: 155 PubMed GONUTS page

[PMID:9649510-45] 46.0 ^46.1 ^46.2 Botquin V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev 12: 2073-90 PubMed GONUTS page

[PMID:16518401-46] Loh YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38: 431-40 PubMed GONUTS page

[PMID:7945330-47] Rosfjord E & Rizzino A (1994) The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Biochem Biophys Res Commun 203: 1795-802 PubMed GONUTS page

[PMID:1690859-48] Schöler HR et al. (1990) New type of POU domain in germ line-specific protein Oct-4. Nature 344: 435-9 PubMed GONUTS page

[PMID:8960364-49] Wang L & Schultz GA (1996) Expression of Oct-4 during differentiation of murine F9 cells. Biochem Cell Biol 74: 579-84 PubMed GONUTS page

[PMID:17097055-50] Tsuruzoe S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun 351: 920-6 PubMed GONUTS page

[PMID:7590241-51] Yuan H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9: 2635-45 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Pou5f1 ( synonyms: Oct-3, Oct-3/4, Oct-4, Oct3/4, Oct4, Otf-3, Otf-4, Otf3, Otf3-rs7, Otf3g, Otf4 )
Protein Name(s)	POU domain, class 5, transcription factor 1,
External Links
MGI	MGI:101893

MGI:Pou5f1

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